| Entry |
|
|---|
| Name |
4-aminobenzoate 1-monooxygenase;
4-aminobenzoate hydroxylase;
4-aminobenzoate monooxygenase |
|---|
| Class |
Oxidoreductases;
Acting on paired donors, with O2 as oxidant and incorporation or
reduction of oxygen. The oxygen incorporated need not be derived
from O2;
With NADH or NADPH as one donor, and incorporation of one atom of
oxygen into the other donor
 |
|---|
| Sysname |
4-aminobenzoate,NAD(P)H:oxygen oxidoreductase (1-hydroxylating,
decarboxylating) |
|---|
| Reaction(IUBMB) |
4-aminobenzoate + NAD(P)H + 2 H+ + O2 = 4-hydroxyaniline + NAD(P)+ +
H2O + CO2 [RN:R02561 R02562] |
|---|
| Reaction(KEGG) |
R02561 R02562
 |
|---|
| Substrate |
4-aminobenzoate [CPD:C00568];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007] |
|---|
| Product |
4-hydroxyaniline [CPD:C02372];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006];
H2O [CPD:C00001];
CO2 [CPD:C00011] |
|---|
| Cofactor |
FAD [CPD:C00016] |
|---|
| Comment |
A flavoprotein (FAD). Acts on anthranilate and 4-aminosalicylate but
not on salicylate (cf. EC 1.14.13.1 salicylate 1-monooxygenase). |
|---|
| Pathway |
PATH: ec00623 2,4-Dichlorobenzoate degradation |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:3489713]
Tsuji H, Ogawa T, Bando N, Sasaoka K.
Purification and properties of 4-aminobenzoate hydroxylase, a new
monooxygenase from Agaricus bisporus.
J. Biol. Chem. 261 (1986) 13203-9.
Agaricus bisporus |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.14.13.27
IUBMB Enzyme Nomenclature: 1.14.13.27
ExPASy - ENZYME nomenclature database: 1.14.13.27
UM-BBD (Biocatalysis/Biodegradation Database): 1.14.13.27
BRENDA, the Enzyme Database: 1.14.13.27
CAS: 98668-55-4 |
|---|
