KEGG   ENZYME: 1.14.13.30Help
Entry
EC 1.14.13.30               Enzyme                                 

Name
leukotriene-B4 20-monooxygenase;
leukotriene-B4 20-hydroxylase;
leucotriene-B4 omega-hydroxylase;
LTB4 20-hydroxylase;
LTB4 omega-hydroxylase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
(6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate,NADPH:oxygen oxidoreductase (20-hydroxylating)
Reaction(IUBMB)
(6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate + NADPH + H+ + O2 = (6Z,8E,10E,14Z)-(5S,12R)-5,12,20-trihydroxyicosa-6,8,10,14-tetraenoate + NADP+ + H2O [RN:R03866]
Reaction(KEGG)
Substrate
(6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate [CPD:C02165];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
(6Z,8E,10E,14Z)-(5S,12R)-5,12,20-trihydroxyicosa-6,8,10,14-tetraenoate [CPD:C04853];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Comment
A heme-thiolate protein (P-450). Not identical with EC 1.14.13.34, leukotriene-E4 20-monooxygenase.
Pathway
Arachidonic acid metabolism
Metabolic pathways
Orthology
K17726  
leukotriene-B4 20-monooxygenase
Genes
HSA: 
4051(CYP4F3) 8529(CYP4F2)
PTR: 
PPS: 
GGO: 
MCC: 
MCF: 
MMU: 
170716(Cyp4f13) 64385(Cyp4f14) 72054(Cyp4f18)
RNO: 
266689(Cyp4f6) 290623(Cyp4f18) 56266(Cyp4f1)
CGE: 
HGL: 
TUP: 
CFA: 
AML: 
FCA: 
BTA: 
100295883 507016(CYP4F2) 507615(CYP4F2) 534967(CYP4F3)
BOM: 
PHD: 
CHX: 
SSC: 
100113470(CYP4F2) 100620559(CYP4F55)
CFR: 
ECB: 
MYB: 
MDO: 
SHR: 
PHI: 
DRE: 
100037390(cyp4f3)
TRU: 
OLA: 
 » show all
Taxonomy
Reference
1  [PMID:3027095]
  Authors
Romano MC, Eckardt RD, Bender PE, Leonard TB, Straub KM, Newton JF.
  Title
Biochemical characterization of hepatic microsomal leukotriene B4 hydroxylases.
  Journal
J. Biol. Chem. 262 (1987) 1590-5.
  Organism
Rattus norvegicus [GN:rno]
Reference
2  [PMID:4044832]
  Authors
Shak S, Goldstein IM.
  Title
Leukotriene B4 omega-hydroxylase in human polymorphonuclear leukocytes. Partial purification and identification as a cytochrome P-450.
  Journal
J. Clin. Invest. 76 (1985) 1218-28.
  Organism
Homo sapiens [GN:hsa]
Reference
3  [PMID:2986111]
  Authors
Soberman RJ, Harper TW, Murphy RC, Austen KF.
  Title
Identification and functional characterization of leukotriene B4 20-hydroxylase of human polymorphonuclear leukocytes.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 82 (1985) 2292-5.
  Organism
Homo sapiens [GN:hsa]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
90119-11-2

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