KEGG   ENZYME: 1.14.13.30Help
Entry
EC 1.14.13.30               Enzyme                                 
Name
leukotriene-B4 20-monooxygenase;
leukotriene-B4 20-hydroxylase;
leucotriene-B4 omega-hydroxylase;
LTB4 20-hydroxylase;
LTB4 omega-hydroxylase
Class
Oxidoreductases;
Acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
(6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate,NADPH:oxygen oxidoreductase (20-hydroxylating)
Reaction(IUBMB)
(6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate + NADPH + H+ + O2 = (6Z,8E,10E,14Z)-(5S,12R)-5,12,20-trihydroxyicosa-6,8,10,14-tetraenoate + NADP+ + H2O [RN:R03866]
Reaction(KEGG)
Substrate
(6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate [CPD:C02165];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
(6Z,8E,10E,14Z)-(5S,12R)-5,12,20-trihydroxyicosa-6,8,10,14-tetraenoate [CPD:C04853];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Comment
A heme-thiolate protein (P-450). Not identical with EC 1.14.13.34, leukotriene-E4 20-monooxygenase.
Pathway
Arachidonic acid metabolism
Metabolic pathways
Orthology
K00490  
cytochrome P450, family 4, subfamily F (leukotriene-B4 20-monooxygenase)
Genes
HSA: 
11283(CYP4F8) 126410(CYP4F22) 4051(CYP4F3) 57834(CYP4F11) 8529(CYP4F2)
PTR: 
PPS: 
GGO: 
PON: 
MCC: 
718303(CYP4F22) 718335(CYP4F8) 718349 719246
MMU: 
106648(Cyp4f15) 170716(Cyp4f13) 208285(Cyp4f17) 320997(Cyp4f39) 631304(Cyp4f40) 64385(Cyp4f14) 70101(Cyp4f16) 72054(Cyp4f18)
RNO: 
266689(Cyp4f6) 286904(Cyp4f4) 286905(Cyp4f5) 290623(Cyp4f18) 299566(Cyp4f39) 500801(Cyp4f17) 503122(Cyp4f40) 56266(Cyp4f1)
CFA: 
AML: 
FCA: 
101089989 101097952
BTA: 
100295883 100301224 507016(CYP4F2) 507615(CYP4F2) 534967(CYP4F3)
SSC: 
100113470(CYP4F2) 100620265 100620559(CYP4F55)
ECB: 
100062102 100063353 100070707
MDO: 
100011399 100013319 100013359 100013446 100013494
SHR: 
100913398 100913664 100929206
OAA: 
100074551
GGA: 
100859277
MGP: 
100550430
TGU: 
100231824
ACS: 
100561551
XLA: 
100037244(cyp4f22) 100337565(cyp4f42)
XTR: 
548527(cyp4f22)
DRE: 
100037390(cyp4f3)
TRU: 
101071805
OLA: 
101170499
BFO: 
BRAFLDRAFT_225290 BRAFLDRAFT_88611
SPU: 
591685
UMA: 
UM00202.1
TET: 
TTHERM_00198320
 » show all
Taxonomy
Reference
1  [PMID:3027095]
  Authors
Romano MC, Eckardt RD, Bender PE, Leonard TB, Straub KM, Newton JF.
  Title
Biochemical characterization of hepatic microsomal leukotriene B4 hydroxylases.
  Journal
J. Biol. Chem. 262 (1987) 1590-5.
  Organism
Rattus norvegicus [GN:rno]
Reference
2  [PMID:4044832]
  Authors
Shak S, Goldstein IM.
  Title
Leukotriene B4 omega-hydroxylase in human polymorphonuclear leukocytes. Partial purification and identification as a cytochrome P-450.
  Journal
J. Clin. Invest. 76 (1985) 1218-28.
  Organism
Homo sapiens [GN:hsa]
Reference
3  [PMID:2986111]
  Authors
Soberman RJ, Harper TW, Murphy RC, Austen KF.
  Title
Identification and functional characterization of leukotriene B4 20-hydroxylase of human polymorphonuclear leukocytes.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 82 (1985) 2292-5.
  Organism
Homo sapiens [GN:hsa]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
90119-11-2
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