| Entry |
|
|---|
| Name |
leukotriene-E4 20-monooxygenase;
leukotriene-E4 omega-hydroxylase |
|---|
| Class |
Oxidoreductases;
Acting on paired donors, with O2 as oxidant and incorporation or
reduction of oxygen. The oxygen incorporated need not be derived
from O2;
With NADH or NADPH as one donor, and incorporation of one atom of
oxygen into the other donor
 |
|---|
| Sysname |
(7E,9E,11Z,14Z)-(5S,6R)-6-(cystein-S-yl)-5-hydroxyicosa-7,9,11,14-te
traenoate,NADPH:oxygen oxidoreductase (20-hydroxylating) |
|---|
| Reaction(IUBMB) |
(7E,9E,11Z,14Z)-(5S,6R)-6-(cystein-S-yl)-5-hydroxyicosa-7,9,11,14-
tetraenoate + NADPH + H+ + O2 = 20-hydroxyleukotriene E4 + NADP+ +
H2O [RN:R04256] |
|---|
| Reaction(KEGG) |
R04256
 |
|---|
| Substrate |
(7E,9E,11Z,14Z)-(5S,6R)-6-(cystein-S-yl)-5-hydroxyicosa-7,9,11,14-
tetraenoate [CPD:C05952];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007] |
|---|
| Product |
20-hydroxyleukotriene E4 [CPD:C03577];
NADP+ [CPD:C00006];
H2O [CPD:C00001] |
|---|
| Comment |
Also acts on N-acetyl-leukotriene E4, but more slowly. Not identical
with EC 1.14.13.30 leukotriene-B4 20-monooxygenase. |
|---|
| Pathway |
PATH: ec00590 Arachidonic acid metabolism |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:2826163]
Orning L.
Omega-oxidation of cysteine-containing leukotrienes by rat-liver
microsomes. Isolation and characterization of omega-hydroxy and
omega-carboxy metabolites of leukotriene E4 and N-acetylleukotriene
E4.
Eur. J. Biochem. 170 (1987) 77-85.
Rattus norvegicus [GN:rno] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.14.13.34
IUBMB Enzyme Nomenclature: 1.14.13.34
ExPASy - ENZYME nomenclature database: 1.14.13.34
BRENDA, the Enzyme Database: 1.14.13.34
CAS: 111940-51-3 |
|---|
|
