| Entry |
|
|---|
| Name |
anhydrotetracycline monooxygenase;
ATC oxygenase;
anhydrotetracycline oxygenase |
|---|
| Class |
Oxidoreductases;
Acting on paired donors, with O2 as oxidant and incorporation or
reduction of oxygen. The oxygen incorporated need not be derived
from O2;
With NADH or NADPH as one donor, and incorporation of one atom of
oxygen into the other donor
 |
|---|
| Sysname |
anhydrotetracycline,NADPH:oxygen oxidoreductase (6-hydroxylating) |
|---|
| Reaction(IUBMB) |
anhydrotetracycline + NADPH + H+ + O2 = 12-dehydrotetracycline +
NADP+ + H2O [RN:R04060] |
|---|
| Reaction(KEGG) |
R04060
 |
|---|
| Substrate |
anhydrotetracycline [CPD:C02811];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007] |
|---|
| Product |
12-dehydrotetracycline [CPD:C03206];
NADP+ [CPD:C00006];
H2O [CPD:C00001] |
|---|
| Comment |
Involved in the biosynthesis of the antibiotics tetracyclines in
Streptomyces sp. |
|---|
| Pathway |
PATH: ec00253 Tetracycline biosynthesis
PATH: ec01057 Biosynthesis of type II polyketide products |
|---|
Reference
Authors
Title
Journal
|
1
Behal, V.
The tetracycline fermentation and its regulation.
CRC Crit. Rev. Biotechnol. 5 (1987) 295-318. |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.14.13.38
IUBMB Enzyme Nomenclature: 1.14.13.38
ExPASy - ENZYME nomenclature database: 1.14.13.38
BRENDA, the Enzyme Database: 1.14.13.38
CAS: 70766-62-0 |
|---|
