| Entry |
|
|---|
| Name |
imidazoleacetate 4-monooxygenase;
imidazoleacetic hydroxylase;
imidazoleacetate hydroxylase;
imidazoleacetic monooxygenase |
|---|
| Class |
Oxidoreductases;
Acting on paired donors, with O2 as oxidant and incorporation or
reduction of oxygen. The oxygen incorporated need not be derived
from O2;
With NADH or NADPH as one donor, and incorporation of one atom of
oxygen into the other donor
 |
|---|
| Sysname |
4-imidazoleacetate,NADH:oxygen oxidoreductase (5-hydroxylating) |
|---|
| Reaction(IUBMB) |
4-imidazoleacetate + NADH + H+ + O2 = 5-hydroxy-4-imidazoleacetate +
NAD+ + H2O [RN:R04066] |
|---|
| Reaction(KEGG) |
R04066
 |
|---|
| Substrate |
4-imidazoleacetate [CPD:C02835];
NADH [CPD:C00004];
H+ [CPD:C00080];
O2 [CPD:C00007] |
|---|
| Product |
5-hydroxy-4-imidazoleacetate [CPD:C05133];
NAD+ [CPD:C00003];
H2O [CPD:C00001] |
|---|
| Cofactor |
FAD [CPD:C00016] |
|---|
| Comment |
A flavoprotein (FAD). |
|---|
| Pathway |
PATH: ec00340 Histidine metabolism |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:5772468]
Maki Y, Yamamoto S, Nozaki M, Hayaishi O.
Studies on monooxygenases. II. Crystallization and some properties
of imidazole acetate monooxygenase.
J. Biol. Chem. 244 (1969) 2942-50.
Pseudomonas sp. |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.14.13.5
IUBMB Enzyme Nomenclature: 1.14.13.5
ExPASy - ENZYME nomenclature database: 1.14.13.5
BRENDA, the Enzyme Database: 1.14.13.5
CAS: 9029-65-6 |
|---|
