| Entry |
|
|---|
| Name |
protopine 6-monooxygenase;
protopine 6-hydroxylase |
|---|
| Class |
Oxidoreductases;
Acting on paired donors, with O2 as oxidant and incorporation or
reduction of oxygen. The oxygen incorporated need not be derived
from O2;
With NADH or NADPH as one donor, and incorporation of one atom of
oxygen into the other donor
 |
|---|
| Sysname |
protopine,NADPH:oxygen oxidoreductase (6-hydroxylating) |
|---|
| Reaction(IUBMB) |
protopine + NADPH + H+ + O2 = 6-hydroxyprotopine + NADP+ + H2O
[RN:R04699] |
|---|
| Reaction(KEGG) |
R04699
 |
|---|
| Substrate |
protopine [CPD:C05189];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007] |
|---|
| Product |
6-hydroxyprotopine [CPD:C05190];
NADP+ [CPD:C00006];
H2O [CPD:C00001] |
|---|
| Comment |
A heme-thiolate protein (P-450) involved in benzophenanthridine
alkaloid synthesis in higher plants. |
|---|
| Pathway |
PATH: ec00950 Isoquinoline alkaloid biosynthesis
PATH: ec01063 Biosynthesis of alkaloids derived from shikimate
pathway
PATH: ec01100 Metabolic pathways |
|---|
Reference
Authors
Title
Journal
|
1
Tanahashi, T. and Zenk, M.H.
Elicitor induction and characterization of microsomal
protopine-6-hydroxylase, the central enzyme in benzophenanthridine
alkaloid biosynthesis.
Phytochemistry 29 (1990) 1113-1122. |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.14.13.55
IUBMB Enzyme Nomenclature: 1.14.13.55
ExPASy - ENZYME nomenclature database: 1.14.13.55
BRENDA, the Enzyme Database: 1.14.13.55
CAS: 128561-60-4 |
|---|
