| Entry |
|
|---|
| Name |
dihydrosanguinarine 10-monooxygenase;
dihydrosanguinarine 10-hydroxylase |
|---|
| Class |
Oxidoreductases;
Acting on paired donors, with O2 as oxidant and incorporation or
reduction of oxygen. The oxygen incorporated need not be derived
from O2;
With NADH or NADPH as one donor, and incorporation of one atom of
oxygen into the other donor
 |
|---|
| Sysname |
dihydrosanguinarine,NADPH:oxygen oxidoreductase (10-hydroxylating) |
|---|
| Reaction(IUBMB) |
dihydrosanguinarine + NADPH + H+ + O2 =
10-hydroxydihydrosanguinarine + NADP+ + H2O [RN:R04702] |
|---|
| Reaction(KEGG) |
R04702
 |
|---|
| Substrate |
dihydrosanguinarine [CPD:C05191];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007] |
|---|
| Product |
10-hydroxydihydrosanguinarine [CPD:C05247];
NADP+ [CPD:C00006];
H2O [CPD:C00001] |
|---|
| Comment |
A heme-thiolate protein (P-450) involved in benzophenanthridine
alkaloid synthesis in higher plants. |
|---|
| Pathway |
PATH: ec00950 Isoquinoline alkaloid biosynthesis
PATH: ec01063 Biosynthesis of alkaloids derived from shikimate
pathway
PATH: ec01100 Metabolic pathways |
|---|
Reference
Authors
Title
Journal
|
1
De-Eknamkul, W., Tanahashi, T. and Zenk, M.H.
Enzymic 10-hydroxylation and 10-O-methylation of dihydrosanguinarine
in dihydrochelirubine formation by Eschscholtzia.
Phytochemistry 31 (1992) 2713-2717. |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.14.13.56
IUBMB Enzyme Nomenclature: 1.14.13.56
ExPASy - ENZYME nomenclature database: 1.14.13.56
BRENDA, the Enzyme Database: 1.14.13.56
CAS: 144388-41-0 |
|---|
