| Entry |
|
|---|
| Name |
4-hydroxyphenylacetaldehyde oxime monooxygenase;
4-hydroxybenzeneacetaldehyde oxime monooxygenase;
cytochrome P450II-dependent monooxygenase;
NADPH-cytochrome P450 reductase (CYP71E1);
CYP71E1;
4-hydroxyphenylacetaldehyde oxime,NADPH:oxygen oxidoreductase |
|---|
| Class |
Oxidoreductases;
Acting on paired donors, with O2 as oxidant and incorporation or
reduction of oxygen. The oxygen incorporated need not be derived
from O2;
With NADH or NADPH as one donor, and incorporation of one atom of
oxygen into the other donor
 |
|---|
| Sysname |
(Z)-4-hydroxyphenylacetaldehyde oxime,NADPH:oxygen oxidoreductase |
|---|
| Reaction(IUBMB) |
(Z)-4-hydroxyphenylacetaldehyde oxime + NADPH + H+ + O2 =
(S)-4-hydroxymandelonitrile + NADP+ + 2 H2O [RN:R05728] |
|---|
| Reaction(KEGG) |
R05728
 |
|---|
| Substrate |
(Z)-4-hydroxyphenylacetaldehyde oxime;
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007] |
|---|
| Product |
(S)-4-hydroxymandelonitrile [CPD:C03742];
NADP+ [CPD:C00006];
H2O [CPD:C00001] |
|---|
| Comment |
This enzyme is involved in the biosynthesis of the cyanogenic
glucoside dhurrin in sorghum, along with EC 1.14.13.41, tyrosine
N-monooxygenase and EC 2.4.1.85, cyanohydrin
beta-glucosyltransferase. |
|---|
| Pathway |
PATH: ec00460 Cyanoamino acid metabolism |
|---|
| Orthology |
KO: K13029 4-hydroxyphenylacetaldehyde oxime monooxygenase |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:237909]
MacFarlane IJ, Lees EM, Conn EE.
The in vitro biosynthesis of dhurrin, the cyanogenic glycoside of
Sorghum bicolor.
J. Biol. Chem. 250 (1975) 4708-13.
Sorghum bicolor [GN:sbi] |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:193443]
Shimada M, Conn EE.
The enzymatic conversion of p-hydroxyphenylacetaldoxime to
p-hydroxymandelonitrile.
Arch. Biochem. Biophys. 180 (1977) 199-207.
Sorghum sp. |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:12114576]
Busk PK, Moller BL.
Dhurrin synthesis in sorghum is regulated at the transcriptional
level and induced by nitrogen fertilization in older plants.
Plant. Physiol. 129 (2002) 1222-31.
Sorghum bicolor [GN:sbi] |
|---|
Reference
Authors
Title
Journal
Organism
|
4 [PMID:15665094]
Kristensen C, Morant M, Olsen CE, Ekstrom CT, Galbraith DW, Moller
BL, Bak S.
Metabolic engineering of dhurrin in transgenic Arabidopsis plants
with marginal inadvertent effects on the metabolome and
transcriptome.
Proc. Natl. Acad. Sci. U. S. A. 102 (2005) 1779-84.
Arabidopsis thaliana [GN:ath] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.14.13.68
IUBMB Enzyme Nomenclature: 1.14.13.68
ExPASy - ENZYME nomenclature database: 1.14.13.68
BRENDA, the Enzyme Database: 1.14.13.68 |
|---|
