KEGG   ENZYME: 1.14.13.7Help
Entry
EC 1.14.13.7                Enzyme                                 

Name
phenol 2-monooxygenase;
phenol hydroxylase;
phenol o-hydroxylase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
phenol,NADPH:oxygen oxidoreductase (2-hydroxylating)
Reaction(IUBMB)
phenol + NADPH + H+ + O2 = catechol + NADP+ + H2O [RN:R00815]
Reaction(KEGG)
Substrate
phenol [CPD:C00146];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
catechol [CPD:C00090];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Comment
A flavoprotein (FAD). Also active with resorcinol and 2-methylphenol.
Pathway
Chlorocyclohexane and chlorobenzene degradation
Toluene degradation
Aminobenzoate degradation
Metabolic pathways
Microbial metabolism in diverse environments
Orthology
K03380  
phenol 2-monooxygenase
Genes
DHA: 
PIC: 
LEL: 
CAL: 
CaO19.11196(PHH2) CaO19.3711(PHH2) CaO19.604(PHH1) CaO19.8237(PHH1)
CTP: 
CDU: 
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SMP: 
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NHE: 
SSL: 
BFU: 
ANI: 
NFI: 
AFM: 
AOR: 
AOR_1_618024(AO090010000367) AOR_1_732144(AO090023000432)
ANG: 
ANI_1_3124014(An01g11800)
AFV: 
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UMA: 
MMW: 
BPH: 
BGE: 
BYI: 
CTT: 
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MET: 
MNO: 
PHL: 
PDE: 
PGV: 
APB: 
CGL: 
NCgl0050(Cgl0050) NCgl2588(Cgl2681)
CGB: 
CGT: 
CAR: 
NFA: 
GPO: 
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 » show all
Taxonomy
Reference
1  [PMID:14478080]
  Authors
NAKAGAWA H, TAKEDA Y.
  Title
Phenol hydroxylase.
  Journal
Biochim. Biophys. Acta. 62 (1962) 423-6.
  Organism
Brevibacterium fuscum
Reference
2  [PMID:4146224]
  Authors
Neujahr HY, Gaal A.
  Title
Phenol hydroxylase from yeast. Purification and properties of the enzyme from Trichosporon cutaneum.
  Journal
Eur. J. Biochem. 35 (1973) 386-400.
  Organism
Trichosporon cutaneum
Reference
3  [PMID:810352]
  Authors
Neujahr HY, Gaal A.
  Title
Phenol hydroxylase from yeast. Sulfhydryl groups in phenol hydroxylase from Trichosporon cutaneum.
  Journal
Eur. J. Biochem. 58 (1975) 351-7.
  Organism
Trichosporon cutaneum
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
UM-BBD (Biocatalysis/Biodegradation Database): 
BRENDA, the Enzyme Database: 
CAS: 
37256-84-1

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