KEGG   ENZYME: 1.14.13.71Help
Entry
EC 1.14.13.71               Enzyme                                 

Name
N-methylcoclaurine 3'-monooxygenase;
N-methylcoclaurine 3'-hydroxylase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
(S)-N-methylcoclaurine,NADPH:oxygen oxidoreductase (3'-hydroxylating)
Reaction(IUBMB)
(S)-N-methylcoclaurine + NADPH + H+ + O2 = (S)-3'-hydroxy-N-methylcoclaurine + NADP+ + H2O [RN:R05732]
Reaction(KEGG)
Substrate
(S)-N-methylcoclaurine [CPD:C05176];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
(S)-3'-hydroxy-N-methylcoclaurine [CPD:C05202];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Comment
A heme-thiolate protein (P-450) involved in benzylisoquinoline alkaloid synthesis in higher plants.
History
EC 1.14.13.71 created 2001
Pathway
Isoquinoline alkaloid biosynthesis
Metabolic pathways
Biosynthesis of secondary metabolites
Orthology
K13385  
N-methylcoclaurine 3'-monooxygenase
Reference
1  [PMID:9681018]
  Authors
Pauli HH, Kutchan TM.
  Title
Molecular cloning and functional heterologous expression of two alleles encoding (S)-N-methylcoclaurine 3'-hydroxylase (CYP80B1), a new methyl jasmonate-inducible cytochrome P-450-dependent mono-oxygenase of benzylisoquinoline alkaloid biosynthesis.
  Journal
Plant. J. 13 (1998) 793-801.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
202420-37-9

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