| Entry |
|
|---|
| Name |
kynurenine 3-monooxygenase;
kynurenine 3-hydroxylase;
kynurenine hydroxylase;
L-kynurenine-3-hydroxylase |
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| Class |
Oxidoreductases;
Acting on paired donors, with O2 as oxidant and incorporation or
reduction of oxygen. The oxygen incorporated need not be derived
from O2;
With NADH or NADPH as one donor, and incorporation of one atom of
oxygen into the other donor
 |
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| Sysname |
L-kynurenine,NADPH:oxygen oxidoreductase (3-hydroxylating) |
|---|
| Reaction(IUBMB) |
L-kynurenine + NADPH + H+ + O2 = 3-hydroxy-L-kynurenine + NADP+ +
H2O [RN:R01960] |
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| Reaction(KEGG) |
R01960
 |
|---|
| Substrate |
L-kynurenine [CPD:C00328];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007] |
|---|
| Product |
3-hydroxy-L-kynurenine [CPD:C03227];
NADP+ [CPD:C00006];
H2O [CPD:C00001] |
|---|
| Cofactor |
FAD [CPD:C00016] |
|---|
| Comment |
A flavoprotein (FAD). |
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| Pathway |
PATH: ec00380 Tryptophan metabolism
PATH: ec01100 Metabolic pathways |
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| Orthology |
KO: K00486 kynurenine 3-monooxygenase |
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| Genes |
HSA: 8564(KMO)
PTR: 469730(KMO)
MCC: 707314(KMO)
MMU: 98256(Kmo)
RNO: 59113(Kmo)
CFA: 480093(KMO)
SSC: 397148(KMO)
ECB: 100060450
MDO: 100027721
OAA: 100083596
GGA: 424041(KMO)
TGU: 100222327
XTR: 448312(kmo)
DRE: 368242(kmo)
CIN: 100186825
SPU: 592365
DME: Dmel_CG1555(cn)
DPO: Dpse_GA24656
DAN: Dana_GF11693
DER: Dere_GG10712
DPE: Dper_GL11242
DSE: Dsec_GM20758
DSI: Dsim_GD15302
DYA: Dyak_GE23640
DGR: Dgri_GH21583
DMO: Dmoj_GI19555
AGA: AgaP_AGAP005948
AAG: AaeL_AAEL008879
CQU: CpipJ_CPIJ017147
AME: 551858
NVI: 100118238
TCA: 641538(Cn)
API: 100166533
ISC: IscW_ISCW011595
CEL: R07B7.5(Monooxygenase)
CBR: CBG23368
NVE: NEMVE_v1g182924 NEMVE_v1g92823
HMG: 100204742
TAD: TRIADDRAFT_24922
PPP: PHYPADRAFT_163844 PHYPADRAFT_72137 PHYPADRAFT_98082
CRE: CHLREDRAFT_171688(SSA14)
SCE: YBL098W(BNA4)
AGO: AGOS_AGL276W
LTH: KLTH0C05786g
DHA: DEHA0C06743g
PIC: PICST_40545(BNA4)
PPA: PAS_chr4_0830
VPO: Kpol_1045p12
LEL: LELG_02289
ZRO: ZYRO0F13002g
CAL: CaO19.12898(BNA4) CaO19.5443(BNA4)
CTP: CTRG_06171
CDU: CD36_80230
YLI: YALI0D09867g
NCR: NCU06924
PAN: PODANSg1515
MGR: MGG_00805
FGR: FG01395.1
ANI: AN5200.2
AOR: AO090005001567
ANG: An07g09110
AFV: AFLA_088010
PCS: Pc18g05760
NFI: NFIA_053020
CIM: CIMG_08021
URE: UREG_02310
SSL: SS1G_13120
BFU: BC1G_05887
CNE: CNC04120
CNB: CNBC3070
UMA: UM06333.1
MBR: MONBRDRAFT_33218
DDI: DDB_0231360(kmo)
PTI: PHATRDRAFT_49644
TPS: THAPSDRAFT_10093
XCC: XCC1552
XCB: XC_2682
XCA: xccb100_2708
XCV: XCV1641
XAC: XAC1600
XOO: XOO2429
XOM: XOO_2306
XOP: PXO_00760
SML: Smlt3161(qbsG)
SMT: Smal_2599
SWD: Swoo_1404
CPS: CPS_3582
LPN: lpg0892
LPF: lpl0923
LPP: lpp0953
LPC: LPC_2401
KKO: Kkor_0376
MXA: MXAN_0916
SGR: SGR_899
SRO: Sros_2189
STP: Strop_3529 Strop_4419
SAQ: Sare_3904 Sare_4893
ABA: Acid345_0681
CHU: CHU_3380
FJO: Fjoh_0495
FPS: FP2212(kmo)
RBI: RB2501_02455
CYP: PCC8801_0812
CYH: Cyan8802_0841
AMR: AM1_0975(kmo) AM1_2357(kmo)
 |
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Reference
Authors
Title
Journal
|
1
de Castro, F.T., Price, J.M. and Brown, R.R.
Reduced triphosphopyridinenucleotide requirement for the enzymatic
formation of 3-hydroxykynurenine from L-kynurenine.
J. Am. Chem. Soc. 78 (1956) 2904-2905. |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:6076241]
Okamoto H, Hayaishi O.
Flavin adenine dinucleotide requirement for kynurenine hydroxylase
of rat liver mitochondria.
Biochem. Biophys. Res. Commun. 29 (1967) 394-9.
Rattus norvegicus [GN:rno] |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:13502353]
SAITO Y, HAYAISHI O, ROTHBERG S.
Studies on oxygenases; enzymatic formation of 3-hydroxy-L-kynurenine
from L-kynurenine.
J. Biol. Chem. 229 (1957) 921-34.
Rattus norvegicus [GN:rno] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.14.13.9
IUBMB Enzyme Nomenclature: 1.14.13.9
ExPASy - ENZYME nomenclature database: 1.14.13.9
BRENDA, the Enzyme Database: 1.14.13.9
CAS: 9029-61-2 |
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