phenylacetone monooxygenase;
PAMO

Oxidoreductases;
Acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor

phenylacetone,NADPH:oxygen oxidoreductase

phenylacetone + NADPH + H+ + O2 = benzyl acetate + NADP+ + H2O [RN:R07201]

R07201

phenylacetone [CPD:C15512];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007]

A flavoprotein (FAD). NADH cannot replace NADPH as coenzyme. In addition to phenylacetone, which is the best substrate found to date, this Baeyer-Villiger monooxygenase can oxidize other aromatic ketones [1-(4-hydroxyphenyl)propan-2-one, 1-(4-hydroxyphenyl)propan-2-one and 3-phenylbutan-2-one], some alipatic ketones (e.g. dodecan-2-one) and sulfides (e.g. 1-methyl-4-(methylsulfanyl)benzene).

1  [PMID:15328411]

Malito E, Alfieri A, Fraaije MW, Mattevi A.

Crystal structure of a Baeyer-Villiger monooxygenase.

Proc. Natl. Acad. Sci. U. S. A. 101 (2004) 13157-62.

Thermobifida fusca [GN:tfu]

2  [PMID:15599520]

Fraaije MW, Wu J, Heuts DP, van Hellemond EW, Spelberg JH, Janssen DB.

Discovery of a thermostable Baeyer-Villiger monooxygenase by genome mining.

Appl. Microbiol. Biotechnol. 66 (2005) 393-400.

Thermobifida fusca [GN:tfu]