KEGG   ENZYME: 1.14.14.1Help
Entry
EC 1.14.14.1                Enzyme                                 
Name
unspecific monooxygenase;
microsomal monooxygenase;
xenobiotic monooxygenase;
aryl-4-monooxygenase;
aryl hydrocarbon hydroxylase;
microsomal P-450;
flavoprotein-linked monooxygenase;
flavoprotein monooxygenase
Class
Oxidoreductases;
Acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
substrate,reduced-flavoprotein:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
Reaction(IUBMB)
RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O [RN:R04122]
Reaction(KEGG)
Substrate
RH [CPD:C01371];
reduced flavoprotein [CPD:C03024];
O2 [CPD:C00007]
Product
ROH [CPD:C01335];
oxidized flavoprotein [CPD:C03161];
H2O [CPD:C00001]
Comment
A group of heme-thiolate proteins (P-450), acting on a wide range of substrates including many xenobiotics, steroids, fatty acids, vitamins and prostaglandins; reactions catalysed include hydroxylation, epoxidation, N-oxidation, sulfooxidation, N-, S- and O-dealkylations, desulfation, deamination, and reduction of azo, nitro and N-oxide groups. Together with EC 1.6.2.4, NADPH---hemoprotein reductase, it forms a system in which two reducing equivalents are supplied by NADPH. Some of the reactions attributed to EC 1.14.15.3, alkane 1-monooxygenase, belong here.
Pathway
Fatty acid metabolism
Steroid hormone biosynthesis
Caffeine metabolism
Tryptophan metabolism
Arachidonic acid metabolism
Linoleic acid metabolism
Aminobenzoate degradation
Retinol metabolism
Metabolism of xenobiotics by cytochrome P450
Drug metabolism - cytochrome P450
Drug metabolism - other enzymes
Metabolic pathways
Microbial metabolism in diverse environments
Orthology
K00493  
unspecific monooxygenase
K07408  
cytochrome P450, family 1, subfamily A, polypeptide 1
K07409  
cytochrome P450, family 1, subfamily A, polypeptide 2
K07410  
cytochrome P450, family 1, subfamily B, polypeptide 1
K07411  
cytochrome P450, family 2, subfamily A
K07412  
cytochrome P450, family 2, subfamily B
K07413  
cytochrome P450, family 2, subfamily C
K07414  
cytochrome P450, family 2, subfamily D
K07415  
cytochrome P450, family 2, subfamily E
K07416  
cytochrome P450, family 2, subfamily F
K07418  
cytochrome P450, family 2, subfamily J
K07420  
cytochrome P450, family 2, subfamily S
K07424  
cytochrome P450, family 3, subfamily A
K07426  
cytochrome P450, family 4, subfamily B
K07428  
cytochrome P450, family 4, subfamily X
K07429  
cytochrome P450, family 4, subfamily Z
K07434  
cytochrome P450, family 19, subfamily A
K14338  
cytochrome P450 / NADPH-cytochrome P450 reductase
Genes
HSA: 
1543(CYP1A1) 1544(CYP1A2) 1545(CYP1B1) 1548(CYP2A6) 1549(CYP2A7) 1551(CYP3A7) 1553(CYP2A13) 1555(CYP2B6) 1557(CYP2C19) 1558(CYP2C8) 1559(CYP2C9) 1562(CYP2C18) 1565(CYP2D6) 1571(CYP2E1) 1572(CYP2F1) 1573(CYP2J2) 1576(CYP3A4) 1577(CYP3A5) 1580(CYP4B1) 1588(CYP19A1) 199974(CYP4Z1) 260293(CYP4X1) 29785(CYP2S1) 64816(CYP3A43)
PTR: 
PPS: 
GGO: 
PON: 
MCC: 
100144394(CYP3A7) 100424240(CYP2C76) 678670(CYP3A4) 678683(CYP2C8) 678686(CYP2C75) 678687(CYP2B6) 678688(CYP2E1) 678689(CYP2A24) 678690(CYP2A23) 678691(CYP2D6) 678692(CYP3A5) 678694(CYP1A1) 678696(CYP2F1) 678697(CYP19A1) 693631 701855(CYP2C18) 705753 709290 709535 709770(CYP3A43) 710385(CYP1B1)
MMU: 
100041375(Cyp3a41b) 100066(Cyp2j11) 107141(Cyp2c50) 13075(Cyp19a1) 13076(Cyp1a1) 13077(Cyp1a2) 13078(Cyp1b1) 13085(Cyp2a12) 13086(Cyp2a4) 13087(Cyp2a5) 13088(Cyp2b10) 13089(Cyp2b13) 13090(Cyp2b19) 13094(Cyp2b9) 13095(Cyp2c29) 13096(Cyp2c37) 13097(Cyp2c38) 13098(Cyp2c39) 13099(Cyp2c40) 13101(Cyp2d10) 13105(Cyp2d9) 13106(Cyp2e1) 13107(Cyp2f2) 13109(Cyp2j5) 13110(Cyp2j6) 13112(Cyp3a11) 13113(Cyp3a13) 13114(Cyp3a16) 13120(Cyp4b1) 226105(Cyp2c70) 226143(Cyp2c44) 230459(Cyp2j13) 242546(Cyp2j12) 243881(Cyp2b23) 337924(Cyp3a44) 404195(Cyp2c54) 433247(Cyp2c68) 53973(Cyp3a41a) 56388(Cyp3a25) 56448(Cyp2d22) 665095(Cyp2j8) 69888(Cyp2c66) 72082(Cyp2c55) 72303(Cyp2c65) 74134(Cyp2s1) 74519(Cyp2j9) 76279(Cyp2d26) 81906(Cyp4x1)
RNO: 
100909962 100910877 171352(Cyp3a9) 171518(Cyp2c22) 171521(Cyp2c13) 171522(Cyp2d4) 24296(Cyp1a1) 24297(Cyp1a2) 24299(Cyp2a3) 24300(Cyp2b1) 24303(Cyp2d3) 24307(Cyp4b1) 246767(Cyp4x1) 24894(Cyp2a1) 24895(Cyp2a2) 25011(Cyp2c12) 25053(Cyp2d2) 25086(Cyp2e1) 25147(Cyp19a1) 252931(Cyp3a18) 25426(Cyp1b1) 25642(Cyp3a23/3a1) 266682(Cyp3a2) 266684(Cyp2d1) 286953(Cyp2b3) 286963(Cyp2d5) 292728(Cyp2b21) 29277(Cyp2c11) 29295(Cyp2b12) 29298(Cyp2c7) 293989(Cyp2c6v1) 308445(Cyp2s1) 313373(Cyp2j10) 313375(Cyp2j3) 361523(Cyp2b2) 499353(Cyp2c24) 502969(Cyp2j16) 54246(Cyp2f4) 65210(Cyp2j4) 83790(Cyp2c23)
CFA: 
100686778(CYP1A1) 100688697 415120(CYP2D15) 415122(CYP2C18) 415123(CYP2C41) 415128(CYP2E1) 415129(CYP3A12) 474177(CYP2B6) 479740(CYP3A4) 482505(CYP4X1) 483038(CYP1B1) 484491(CYP2S1) 484494(CYP2A13) 494003(CYP19A1) 494010(CYP1A2) 608452(CYP4B1) 610195(CYP2J2) 612477
AML: 
FCA: 
100500743(CYP2D6) 100642187(CYP3A132) 100652377(CYP3A131) 101087438 101089396 101089804 101089816 101094932(CYP19A1) 101096660 101096906 101097746 554227(CYP2E2) 554345(CYP1A2) 554347(CYP1A1)
BTA: 
100847677 281740(CYP19A1) 282211(CYP2D14) 282213(CYP2E1) 282214(CYP3A5) 282870(CYP1A1) 503552(CYP1A2) 504769(CYP2B6) 507988(CYP3A4) 510406(CYP2J2) 511470(CYP1B1) 511498 514971(CYP2S1) 526682(CYP3A5) 530571 530929(CYP2J2) 535243(CYP2C18) 540149(CYP4B1) 540707(CYP2A13) 785824(MGC127055)
SSC: 
100126281(CYP3A46) 100144468(CYP3A22) 100152910(CYP1A2) 100523190 100523909 100524750(CYP2J34) 100524940 100625479 100627093 397687(CYP2D25) 403103(CYP1A1) 403104(CYP2B22) 403106(CYP2C32) 403107(CYP2C33) 403111(CYP2C42) 403149(CYP2A19) 403215(CYP2C49) 403216(CYP2E1) 403322(CYP3A39) 403324(CYP3A29) 403331(CYP19A1) 403333(CYP19A3)
ECB: 
100009712(CYP19A1) 100051552 100056087 100061440(CYP2C92) 100061579 100061609 100062244 100062285(CYP1A1) 100064176 100064287 100066422(CYP2E1) 100067041(CYP3A93) 100067064(CYP3A89) 100067084(CYP3A94) 100067109(CYP3A95) 100067247 100068315 100068569 100070088 100070400 100070895 100070962 100146391 100146413 100147675
MDO: 
100010745 100010783 100010820 100011610 100013114 100013238 100015828 100018790(CYPIIF2) 100018858 100018927 100018994 100023149 100023204 100023235 100023529 100023582 100026598 100026637 100029871 100029908 100031295 100031907 100031975 100031980 100031984
SHR: 
100915303 100915447 100916811 100918011 100921428 100921692 100921949 100922209 100923691 100925532 100926939 100927632 100927711 100928062 100929873 100930522 100931571 100933766 100935353
OAA: 
100074279 100078619 100079784(CYP1B1) 100080942(CYP1A1) 100082218 100082250 100086809 100087745 100090373 100091970
GGA: 
396051(CYP1A1) 414832(CYP3A7) 414833(CYP2C45) 414841(CYP2C18) 414854(CYP19A1) 416477(CYP3A4) 417981(CYP2D6c) 421466(CYP1B1) 424618(CYP4B1) 424676 424678(CYP2J2) 424729 428832(CYP1B1) 771974
MGP: 
100538434 100538588 100542888 100544448 100545683 100547794 100548322 100549121 100549427 664714(CYP1A5) 678668(CYP3A80) 678669(CYP3A37)
TGU: 
100217987 100222415 100224220 100226034 100228872 100228937 100230258 100230890 100231862 751777(CYP19A1)
ACS: 
100552139 100555955 100557851 100559530 100561291 100561693 100561903 100562097 100562499 100562694 100565059 100565397(cyp19a1) 100565447 100566907 100567522 100567684 100567926
XLA: 
100036770(cyp2a6) 100036771(cyp4b1.2) 100036775(cyp1a1) 100036876 100037189(cyp3a4) 100337623 373549(cypxl301-a) 373656(cyp19a1) 379297(cyp2c8.1) 379479(cyp2d6-b) 398964 432343(cyp2c18) 432347 444542(cyp2c8.2) 446878(cyp2d6) 495363(cyp3a5)
XTR: 
100036594(cyp19a1) 100037911(cyp1a1) 100487054 100487665 100487893 100487918 100488227 100490477 100495359 448236(cyp2c8.2) 496407(cyp2a6) 496408(cyp2f2) 548436(cyp2d6) 548503(cyp3a4) 550102(cyp4b1.2)
DRE: 
100034366(cyp2p8) 100150054(cyp1b1) 140634(cyp1a) 30390(cyp19a1a) 387527(cyp4t8) 393592(cyp2p9) 399485(cyp2p10) 553637(cyp1c1) 553969(cyp3a65) 60640(cyp19a1b) 797309(cyp2j20)
TRU: 
101061847 101066452 101069124 101073188 101074446 101074542 101075700 101075926 101076508(pfCYP19A)
OLA: 
100125806(cyp1a) 100125815(cyp19b) 100125817(cyp3a40) 100302452(cyp2p3) 101159216 101165838 101173514 101174651(Aromatase)
BFO: 
BRAFLDRAFT_114712 BRAFLDRAFT_201702 BRAFLDRAFT_247066 BRAFLDRAFT_57483
CIN: 
100169892 100182809 100185121 100187173
SPU: 
578598 578655 578821 579059 581116
AGA: 
AgaP_AGAP000818 AgaP_AGAP012294 AgaP_AGAP012295(CYP9L1) AgaP_AGAP012296
CQU: 
CpipJ_CPIJ010175 CpipJ_CPIJ010539 CpipJ_CPIJ010541 CpipJ_CPIJ010544 CpipJ_CPIJ012470
AME: 
409677(Cyp6as5) 412209(CYP6AS4)
CEL: 
CELE_C49C8.4(cyp-33E1) CELE_F42A9.5(cyp-33E2) CELE_R08F11.3(cyp-33C8) CELE_Y49C4A.9(cyp-33C11)
CBR: 
CBG01027(Cbr-cyp-13A6) CBG01302
NVE: 
NEMVE_v1g142057
TAD: 
TRIADDRAFT_13664
CSV: 
101213143
SMO: 
SELMODRAFT_144382(CYP703C2_v2)
PPP: 
PHYPADRAFT_204665
SCE: 
YDR402C(DIT2)
AGO: 
AGOS_AFR400C
KLA: 
KLLA0C06743g KLLA0D11638g
LTH: 
KLTH0G02882g
VPO: 
Kpol_364p9
ZRO: 
ZYRO0D11682g
CGR: 
CAGL0F02607g
PIC: 
PICST_35590(ALK2) PICST_63000(CYP559)
LEL: 
LELG_03266
CDU: 
CD36_30030(DIT2)
CLU: 
CLUG_02306
NCR: 
NCU05185
SMP: 
SMAC_07143
PAN: 
PODANSg3804 PODANSg5780
TTT: 
THITE_2144773
MTM: 
MYCTH_101224
MGR: 
MGG_01925 MGG_10879
FGR: 
FG01972.1 FG07596.1
NHE: 
NECHADRAFT_37323 NECHADRAFT_85746
VAL: 
VDBG_05527
SSL: 
SS1G_11697
BFU: 
BC1G_05268 BC1G_11409 BC1G_15490
ANI: 
AN2706.2 AN6835.2
NFI: 
NFIA_004540 NFIA_067930
AFM: 
AFUA_1G04390 AFUA_3G09220 AFUA_5G02620
AOR: 
AOR_1_772164(AO090001000445)
ANG: 
ANI_1_2654014(An01g06820) ANI_1_396144(An16g02820)
AFV: 
AFLA_100450 AFLA_100460 AFLA_127500
ACT: 
ACLA_037140
PCS: 
Pc20g04310
CPW: 
CPC735_057100
URE: 
UREG_00550 UREG_04911
ABE: 
ARB_05231
TVE: 
TRV_02270
PNO: 
SNOG_15063
PTE: 
PTT_08649 PTT_14357
ZTR: 
MYCGRDRAFT_70343(CYP-50)
MPR: 
MPER_10471
SCM: 
SCHCODRAFT_235382
NGR: 
NAEGRDRAFT_58772
DPP: 
DICPUDRAFT_43840
TET: 
TTHERM_00101170 TTHERM_00101290 TTHERM_00198200 TTHERM_00198220 TTHERM_00198230 TTHERM_00198340 TTHERM_00200550 TTHERM_00201630 TTHERM_00227020 TTHERM_00313500 TTHERM_00620930 TTHERM_00754700 TTHERM_00754730 TTHERM_00898320 TTHERM_01122780 TTHERM_01250020 TTHERM_01369770 TTHERM_01698320
PCT: 
PC1_0268
PEN: 
PSEEN2155
FTU: 
FTT_0632c
FTF: 
FTF0632c
MME: 
Marme_4095
RPI: 
Rpic_4258
RPF: 
Rpic12D_4368
REH: 
H16_B0939(cyp) H16_B1009
RME: 
Rmet_3467
CNC: 
CNE_2c09660(cypE)
BUR: 
Bcep18194_B0775 Bcep18194_B1689 Bcep18194_C6803
VAP: 
Vapar_4796
VPE: 
Varpa_5460
HOH: 
Hoch_2584
MLO: 
mll8468
SME: 
SMc01812
ATU: 
Atu1256
RET: 
RHE_CH01585
RLE: 
RL1686
BJA: 
blr2882
BJU: 
BJ6T_68860
BRA: 
BRADO0283
BBT: 
BBta_0276
BRS: 
S23_51340
RPB: 
RPB_3645
RPD: 
RPD_1820
RPE: 
RPE_0057
AZC: 
AZC_3520
SIT: 
TM1040_1816
RSP: 
RSP_1946
RSQ: 
Rsph17025_0342
RDE: 
RD1_2962(cyp)
ELI: 
ELI_00100
BSU: 
BSU07250(yetO) BSU27160(cypB)
BSR: 
I33_0816 I33_2757
BSL: 
A7A1_0357 A7A1_1768
BSH: 
BSU6051_07250(yetO) BSU6051_27160(cypB)
BSY: 
I653_03650 I653_12890
BSS: 
BSUW23_03690(cypD) BSUW23_13125(cypB)
BST: 
GYO_0986 GYO_2953
BSO: 
BSNT_01238(yetO) BSNT_03936
BSN: 
BSn5_04360 BSn5_15535
BSQ: 
B657_07250(cypD) B657_27160(cypB)
BSUB: 
BEST7613_0718(yetO) BEST7613_4216(cypB)
BSX: 
C663_0751(cypD) C663_2550(cypE)
BLI: 
BL02398(cypE)
BLD: 
BLi02848(yrhJ)
BAO: 
BAMF_0695(yetO) BAMF_2522(cypB)
BAY: 
RBAM_007390(yetO) RBAM_024260(yrhJ)
BAQ: 
BACAU_0708(yetO) BACAU_2438(yrhJ)
BYA: 
BANAU_0661(yetO) BANAU_2583(yrhJ)
BAMP: 
B938_03495 B938_12535
BAML: 
BAM5036_0659(cypD) BAM5036_2365(cypB)
BAZ: 
BAMTA208_03280(yetO) BAMTA208_13325(cypB)
BQL: 
LL3_00745(yetO) LL3_02800(yrhJ)
BXH: 
BAXH7_00690(yetO) BAXH7_02724(yrhJ)
BQY: 
MUS_0726(yetO) MUS_2901(yrhJ)
BAMI: 
KSO_007250 KSO_016080
BAE: 
BATR1942_01195 BATR1942_11285
BAN: 
BA_3221(cypD)
BAR: 
GBAA_3221(cypD)
BAT: 
BAS2993
BAH: 
BAMEG_1392(cypD)
BAI: 
BAA_3269(cypD)
BAX: 
H9401_3072
BAL: 
BACI_c31660
BCE: 
BC3211
BCA: 
BCE_3239(cypD)
BCZ: 
BCZK2921
BCR: 
BCAH187_A3250(cypD)
BCB: 
BCB4264_A3231(cypD)
BCU: 
BCAH820_3229(cypD)
BCG: 
BCG9842_B2016(cypD)
BCQ: 
BCQ_3034(cypD)
BCX: 
BCA_3251(cypD)
BNC: 
BCN_3047
BCF: 
bcf_15685
BCER: 
BCK_18985
BTK: 
BT9727_2981
BTL: 
BALH_2868
BTB: 
BMB171_C2898(cypD)
BTT: 
HD73_2783
BTC: 
CT43_CH3164(cypD)
BTF: 
YBT020_15915
BTM: 
MC28_2359
BTG: 
BTB_c32980(cypD)
BTI: 
BTG_03315
BTN: 
BTF1_13525
BTHT: 
H175_ch3219
BWE: 
BcerKBAB4_2936
BPU: 
BPUM_1680(yrhJ)
BMQ: 
BMQ_3237
BMD: 
BMD_3248
BMH: 
BMWSH_1945(cypD)
BJS: 
MY9_0816 MY9_2696
HHD: 
HBHAL_1310
GYM: 
GYMC10_2763
PPM: 
PPSC2_c3726
PMS: 
KNP414_03453(cypD)
PMW: 
B2K_06870
MGI: 
Mflv_4801
MSP: 
Mspyr1_42110
MRH: 
MycrhN_0071
NFA: 
pnf11580
RHA: 
RHA1_ro04627
RER: 
RER_08960
ROP: 
ROP_47240
REQ: 
REQ_07100
GBR: 
Gbro_3962
SRT: 
Srot_2462
SCO: 
SCO0801(SCF43.12) SCO3636(SCH10.14c)
SMA: 
SAV_4539(cyp20) SAV_575(cyp2) SAV_7426(cyp27)
SCB: 
SCAB_5931 SCAB_9321
SCT: 
SCAT_4838(CYP102A)
SCY: 
SCATT_48330
SHY: 
SHJG_8055
SHO: 
SHJGH_7817
SDV: 
BN159_1745(cypD)
NCA: 
Noca_3536
SRO: 
Sros_6421
FAL: 
FRAAL1514 FRAAL5644
NML: 
Namu_2612 Namu_5109
SEN: 
SACE_0125(cyp20) SACE_2802 SACE_4144 SACE_4205(cypD) SACE_5309(cyp20)
PDX: 
Psed_5892
SGN: 
SGRA_1002
SACI: 
Sinac_6636
AVA: 
Ava_1981 Ava_2103 Ava_3921 Ava_4063
HAU: 
Haur_2522
DGE: 
Dgeo_0944
DDR: 
Deide_08170
DGO: 
DGo_PB0521(cypD)
PTO: 
PTO0085 PTO1399
 » show all
Taxonomy
Reference
1  [PMID:13426111]
  Authors
BOOTH J, BOYLAND E.
  Title
The biochemistry of aromatic amines.  III.  Enzymic hydroxylation by rat-liver microsomes.
  Journal
Biochem. J. 66 (1957) 73-8.
  Organism
Rattus norvegicus [GN:rno]
Reference
2  [PMID:5132997]
  Authors
Fujita T, Mannering GJ.
  Title
Differences in soluble P-450 hemoproteins from livers of rats treated with phenobarbital and 3-methylcholanthrene.
  Journal
Chem. Biol. Interact. 3 (1971) 264-5.
  Organism
Rattus norvegicus [GN:rno]
Reference
3  [PMID:187601]
  Authors
Haugen DA, Coon MJ.
  Title
Properties of electrophoretically homogeneous phenobarbital-inducible and beta-naphthoflavone-inducible forms of liver microsomal cytochrome P-450.
  Journal
J. Biol. Chem. 251 (1976) 7929-39.
  Organism
Oryctolagus cuniculus
Reference
4  [PMID:3415241]
  Authors
Imaoka S, Inoue K, Funae Y.
  Title
Aminopyrine metabolism by multiple forms of cytochrome P-450 from rat liver microsomes: simultaneous quantitation of four aminopyrine metabolites by high-performance liquid chromatography.
  Journal
Arch. Biochem. Biophys. 265 (1988) 159-70.
  Organism
Rattus norvegicus [GN:rno]
Reference
5  [PMID:434823]
  Authors
Johnson EF, Zounes MC, Muller-Eberhard U.
  Title
Characterization of three forms of rabbit microsomal cytochrome P-450 by peptide mapping utilizing limited proteolysis in sodium dodecyl sulfate and analysis by gel electrophoresis.
  Journal
Arch. Biochem. Biophys. 192 (1979) 282-9.
  Organism
Oryctolagus cuniculus
Reference
6  [PMID:489601]
  Authors
Kupfer D, Miranda GK, Navarro J, Piccolo DE, Theoharides AD.
  Title
Effect of inducers and inhibitors of monooxygenase on the hydroxylation of prostaglandins in the guinea pig. Evidence for several monooxygenases catalyzing omega- and omega-1-hydroxylation.
  Journal
J. Biol. Chem. 254 (1979) 10405-14.
  Organism
Cavia porcellus
Reference
7  [PMID:7298645]
  Authors
Lang MA, Gielen JE, Nebert DW.
  Title
Genetic evidence for many unique liver microsomal P-450-mediated monooxygenase activities in heterogeneic stock mice.
  Journal
J. Biol. Chem. 256 (1981) 12068-75.
  Organism
Mus musculus [GN:mmu]
Reference
8  [PMID:7298644]
  Authors
Lang MA, Nebert DW.
  Title
Structural gene products of the Ah locus. Evidence for many unique P-450-mediated monooxygenase activities reconstituted from 3-methylcholanthrene-treated C57BL/6N mouse liver microsomes.
  Journal
J. Biol. Chem. 256 (1981) 12058-67.
  Organism
Mus musculus [GN:mmu]
Reference
9  [PMID:2916844]
  Authors
Leo MA, Lasker JM, Raucy JL, Kim CI, Black M, Lieber CS.
  Title
Metabolism of retinol and retinoic acid by human liver cytochrome P450IIC8.
  Journal
Arch. Biochem. Biophys. 269 (1989) 305-12.
  Organism
Homo sapiens [GN:hsa]
Reference
10 [PMID:4401153]
  Authors
Lu AY, Kuntzman R, West S, Jacobson M, Conney AH.
  Title
Reconstituted liver microsomal enzyme system that hydroxylates drugs, other foreign compounds, and endogenous substrates. II. Role of the cytochrome P-450 and P-448 fractions in drug and steroid hydroxylations.
  Journal
J. Biol. Chem. 247 (1972) 1727-34.
  Organism
Rattus norvegicus [GN:rno]
Reference
11 [PMID:13314626]
  Authors
MITOMA C, POSNER HS, REITZ HC, UDENFRIEND S.
  Title
Enzymatic hydroxylation of aromatic compounds.
  Journal
Arch. Biochem. Biophys. 61 (1956) 431-41.
  Organism
Oryctolagus cuniculus
Reference
12
  Authors
Mitoma, C. and Udenfriend, S.
  Title
Aryl-4-hydroxylase.
  Journal
Methods Enzymol. 5 (1962) 816-819.
Reference
13 [PMID:7295706]
  Authors
Napoli JL, Okita RT, Masters BS, Horst RL.
  Title
Identification of 25,26-dihydroxyvitamin D3 as a rat renal 25-hydroxyvitamin D3 metabolite.
  Journal
Biochemistry. 20 (1981) 5865-71.
  Organism
Rattus norvegicus [GN:rno]
Reference
14 [PMID:4387094]
  Authors
Nebert DW, Gelboin HV.
  Title
Substrate-inducible microsomal aryl hydroxylase in mammalian cell culture. I. Assay and properties of induced enzyme.
  Journal
J. Biol. Chem. 243 (1968) 6242-9.
  Organism
Rattus norvegicus [GN:rno]
Reference
15 [PMID:3264134]
  Authors
Suhara K, Ohashi K, Takahashi K, Katagiri M.
  Title
Aromatase and nonaromatizing 10-demethylase activity of adrenal cortex mitochondrial P-450(11)beta.
  Journal
Arch. Biochem. Biophys. 267 (1988) 31-7.
  Organism
Homo sapiens [GN:hsa], Bos taurus [GN:bta]
Reference
16 [PMID:7462235]
  Authors
Theoharides AD, Kupfer D.
  Title
Evidence for different hepatic microsomal monooxygenases catalyzing omega- and (omega-1)-hydroxylations of prostaglandins E1 and E2. Effects of inducers of monooxygenase on the kinetic constants of prostaglandin hydroxylation.
  Journal
J. Biol. Chem. 256 (1981) 2168-75.
  Organism
Oryctolagus cuniculus
Reference
17 [PMID:825720]
  Authors
Thomas PE, Lu AY, Ryan D, West SB, Kawalek J, Levin W.
  Title
Immunochemical evidence for six forms of rat liver cytochrome P450 obtained using antibodies against purified rat liver cytochromes P450 and P448.
  Journal
Mol. Pharmacol. 12 (1976) 746-58.
  Organism
Rattus norvegicus [GN:rno]
Other DBs
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