KEGG   ENZYME: 1.14.15.4Help
Entry
EC 1.14.15.4                Enzyme                                 
Name
steroid 11beta-monooxygenase;
steroid 11beta-hydroxylase;
steroid 11beta/18-hydroxylase
Class
Oxidoreductases;
Acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2;
With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
steroid,reduced-adrenodoxin:oxygen oxidoreductase (11beta-hydroxylating)
Reaction(IUBMB)
a steroid + reduced adrenodoxin + O2 = an 11beta-hydroxysteroid + oxidized adrenodoxin + H2O [RN:R02726]
Reaction(KEGG)
Substrate
steroid [CPD:C00377];
reduced adrenodoxin [CPD:C00662];
O2 [CPD:C00007]
Product
11beta-hydroxysteroid [CPD:C01058];
oxidized adrenodoxin [CPD:C00667];
H2O [CPD:C00001]
Comment
A heme-thiolate protein (P-450). Also hydroxylates steroids at the 18-position, and converts 18-hydroxycorticosterone into aldosterone.
Pathway
Steroid hormone biosynthesis
Metabolic pathways
Orthology
K00497  
cytochrome P450, family 11, subfamily B1 (steroid 11beta-monooxygenase)
K07433  
cytochrome P450, family 11, subfamily B2 (steroid 11beta-monooxygenase / corticosterone 18-monooxygenase)
Genes
HSA: 
1584(CYP11B1) 1585(CYP11B2)
PTR: 
PPS: 
GGO: 
PON: 
MCC: 
695793(CYP11B1) 695914(CYP11B2)
MMU: 
110115(Cyp11b1) 13072(Cyp11b2)
RNO: 
24294(Cyp11b2) 353498(Cyp11b3) 500892(Cyp11b1)
CFA: 
482071(CYP11B2)
AML: 
FCA: 
101097790
BTA: 
282422(CYP11B1)
ECB: 
100063645
MDO: 
100032885
SHR: 
100930767
OAA: 
100082065
ACS: 
100560890
 » show all
Taxonomy
Reference
1  [PMID:13276417]
  Authors
GRANT JK, BROWNIE AC.
  Title
The role of fumarate and TPN in steroid enzymic 11beta-hydroxylation.
  Journal
Biochim. Biophys. Acta. 18 (1955) 433-4.
Reference
2  [PMID:13211659]
  Authors
HAYANO M, DORFMAN RI.
  Title
On the mechanism of the C11 beta-hydroxylation of steroids.
  Journal
J. Biol. Chem. 211 (1954) 227-35.
  Organism
Bos taurus [GN:bta]
Reference
3  [PMID:13426185]
  Authors
TOMKINS GM, MICHAEL PJ, CURRAN JF.
  Title
Studies on the nature of steroid 11-beta hydroxylation.
  Journal
Biochim. Biophys. Acta. 23 (1957) 655-6.
  Organism
Bos taurus [GN:bta], Oryctolagus cuniculus
Reference
4  [PMID:3485096]
  Authors
Yanagibashi K, Haniu M, Shively JE, Shen WH, Hall P.
  Title
The synthesis of aldosterone by the adrenal cortex. Two zones (fasciculata and glomerulosa) possess one enzyme for 11 beta-, 18-hydroxylation, and aldehyde synthesis.
  Journal
J. Biol. Chem. 261 (1986) 3556-62.
  Organism
Bos taurus [GN:bta], Sus scofa [GN:ssc]
Reference
5  [PMID:4967077]
  Authors
Zuidweg MH.
  Title
Hydroxylation of Reichstein's compound S with cell-free preparations from Curvularia lunata.
  Journal
Biochim. Biophys. Acta. 152 (1968) 144-58.
  Organism
Curvularia lunata
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9029-66-7
DBGET integrated database retrieval system