| Entry |
|
|---|
| Name |
anthranilate 3-monooxygenase;
anthranilate 3-hydroxylase;
anthranilate hydroxylase;
anthranilic hydroxylase;
anthranilic acid hydroxylase |
|---|
| Class |
Oxidoreductases;
Acting on paired donors, with O2 as oxidant and incorporation or
reduction of oxygen. The oxygen incorporated need not be derived
from O2;
With reduced pteridine as one donor, and incorporation of one atom
of oxygen into the other donor
 |
|---|
| Sysname |
anthranilate,tetrahydrobiopterin:oxygen oxidoreductase
(3-hydroxylating) |
|---|
| Reaction(IUBMB) |
anthranilate + tetrahydrobiopterin + O2 = 3-hydroxyanthranilate +
dihydrobiopterin + H2O [RN:R01816] |
|---|
| Reaction(KEGG) |
R01816
 |
|---|
| Substrate |
anthranilate [CPD:C00108];
tetrahydrobiopterin [CPD:C00272];
O2 [CPD:C00007] |
|---|
| Product |
3-hydroxyanthranilate [CPD:C00632];
dihydrobiopterin [CPD:C00268];
H2O [CPD:C00001] |
|---|
| Cofactor |
Iron [CPD:C00023] |
|---|
| Comment |
Requires Fe2+. |
|---|
| Pathway |
PATH: ec00380 Tryptophan metabolism |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:5789774]
Jequier E, Robinson DS, Lovenberg W, Sjoerdsma A.
Further studies on tryptophan hydroxylase in rat brainstem and beef
pineal.
Biochem. Pharmacol. 18 (1969) 1071-81.
Rattus norvegicus [GN:rno], Bos taurus [GN:bta] |
|---|
Reference
Authors
Title
Journal
|
2
Nair, P.M. and Vaidyanathan, C.S.
Anthranilic acid hydroxylase from Tecoma stans.
Biochim. Biophys. Acta 110 (1965) 521-531. |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.14.16.3
IUBMB Enzyme Nomenclature: 1.14.16.3
ExPASy - ENZYME nomenclature database: 1.14.16.3
BRENDA, the Enzyme Database: 1.14.16.3
CAS: 37256-79-4 |
|---|
