| Entry |
|
|---|
| Name |
dopamine beta-monooxygenase;
dopamine beta-hydroxylase;
MDBH (membrane-associated dopamine beta-monooxygenase);
SDBH (soluble dopamine beta-monooxygenase);
dopamine-B-hydroxylase;
oxygenase, dopamine beta-mono-;
3,4-dihydroxyphenethylamine beta-oxidase;
4-(2-aminoethyl)pyrocatechol beta-oxidase;
dopa beta-hydroxylase;
dopamine beta-oxidase;
dopamine hydroxylase;
phenylamine beta-hydroxylase;
(3,4-dihydroxyphenethylamine)beta-mono-oxygenase |
|---|
| Class |
Oxidoreductases;
Acting on paired donors, with O2 as oxidant and incorporation or
reduction of oxygen. The oxygen incorporated need not be derived
from O2;
With reduced ascorbate as one donor, and incorporation of one atom
of oxygen into the other donor
 |
|---|
| Sysname |
3,4-dihydroxyphenethylamine,ascorbate:oxygen oxidoreductase
(beta-hydroxylating) |
|---|
| Reaction(IUBMB) |
3,4-dihydroxyphenethylamine + ascorbate + O2 = noradrenaline +
dehydroascorbate + H2O [RN:R02535] |
|---|
| Reaction(KEGG) |
R02535
 |
|---|
| Substrate |
3,4-dihydroxyphenethylamine [CPD:C03758];
ascorbate [CPD:C00072];
O2 [CPD:C00007] |
|---|
| Product |
noradrenaline [CPD:C00547];
dehydroascorbate [CPD:C05422];
H2O [CPD:C00001] |
|---|
| Cofactor |
Copper [CPD:C00070];
PQQ [CPD:C00113];
Fumarate [CPD:C00122] |
|---|
| Comment |
A copper protein. Stimulated by fumarate. |
|---|
| Pathway |
PATH: ec00350 Tyrosine metabolism
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K00503 dopamine beta-monooxygenase |
|---|
| Genes |
HSA: 1621(DBH)
PTR: 464827(DBH)
MCC: 574105
MMU: 13166(Dbh)
RNO: 25699(Dbh)
CFA: 448806(DBH)
BTA: 280758(DBH)
ECB: 791247(DBH)
MDO: 100018814
OAA: 100073905
GGA: 395549(DBH)
DRE: 30505(dbh)
DME: Dmel_CG1543(Tbh)
DPO: Dpse_GA11749
CEL: H13N06.6(tbh-1)
 |
|---|
| Structures |
PDB: 1ZHB |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:5846992]
Friedman S, Kaufman S.
3,4-dihydroxyphenylethylamine beta-hydroxylase. Physical properties,
copper content, and role of copper in the catalytic acttivity.
J. Biol. Chem. 240 (1965) 4763-73.
Bos taurus [GN:bta] |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:14416204]
LEVIN EY, LEVENBERG B, KAUFMAN S.
The enzymatic conversion of 3,4-dihydroxyphenylethylamine to
norepinephrine.
J. Biol. Chem. 235 (1960) 2080-6.
Bos taurus [GN:bta] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.14.17.1
IUBMB Enzyme Nomenclature: 1.14.17.1
ExPASy - ENZYME nomenclature database: 1.14.17.1
BRENDA, the Enzyme Database: 1.14.17.1
CAS: 9013-38-1 |
|---|
