KEGG   ENZYME: 1.14.17.1Help
Entry
EC 1.14.17.1                Enzyme                                 
Name
dopamine beta-monooxygenase;
dopamine beta-hydroxylase;
MDBH (membrane-associated dopamine beta-monooxygenase);
SDBH (soluble dopamine beta-monooxygenase);
dopamine-B-hydroxylase;
3,4-dihydroxyphenethylamine beta-oxidase;
4-(2-aminoethyl)pyrocatechol beta-oxidase;
dopa beta-hydroxylase;
dopamine beta-oxidase;
dopamine hydroxylase;
phenylamine beta-hydroxylase;
(3,4-dihydroxyphenethylamine)beta-mono-oxygenase;
DbetaM (gene name)
Class
Oxidoreductases;
Acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2;
With reduced ascorbate as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
dopamine,ascorbate:oxygen oxidoreductase (beta-hydroxylating)
Reaction(IUBMB)
dopamine + ascorbate + O2 = noradrenaline + dehydroascorbate + H2O [RN:R02535]
Reaction(KEGG)
Substrate
dopamine [CPD:C03758];
ascorbate [CPD:C00072];
O2 [CPD:C00007]
Product
noradrenaline [CPD:C00547];
dehydroascorbate [CPD:C05422];
H2O [CPD:C00001]
Comment
A copper protein. Stimulated by fumarate.
Pathway
Tyrosine metabolism
Metabolic pathways
Orthology
K00503  
dopamine beta-monooxygenase
Genes
HSA: 
1621(DBH)
PTR: 
464827(DBH)
PPS: 
GGO: 
PON: 
MCC: 
574105(DBH)
MMU: 
13166(Dbh)
RNO: 
25699(Dbh)
CFA: 
448806(DBH)
AML: 
FCA: 
101082957(DBH)
BTA: 
280758(DBH)
SSC: 
733609(DBH)
ECB: 
791247(DBH)
MDO: 
100018814
SHR: 
100925655(DBH)
OAA: 
100073905
GGA: 
395549(DBH)
MGP: 
100544779
TGU: 
100224356(DBH)
ACS: 
100566843
XTR: 
100492247
DRE: 
30505(dbh)
TRU: 
101066621
OLA: 
101157870
BFO: 
BRAFLDRAFT_215529
CIN: 
100176680
SPU: 
586320
DME: 
Dmel_CG1543(Tbh)
DPO: 
Dpse_GA11749 Dpse_GA22782
DAN: 
Dana_GF21296
DER: 
Dere_GG19681
DPE: 
Dper_GL15140
DSE: 
Dsec_GM11221
DSI: 
Dsim_GD16874(Dsim_Tbh)
DWI: 
Dwil_GK19855
DYA: 
Dyak_GE15754
DGR: 
Dgri_GH24481
DMO: 
Dmoj_GI11219
DVI: 
Dvir_GJ16861
AGA: 
AgaP_AGAP010485
AAG: 
AaeL_AAEL010856
CQU: 
CpipJ_CPIJ019622
AME: 
751102(Tbh)
NVI: 
100119029(NV15929)
TCA: 
663011(TcTBH)
API: 
100166363
PHU: 
Phum_PHUM211140
ISC: 
IscW_ISCW000229
CBR: 
CBG07714(Cbr-tbh-1)
SMM: 
Smp_163900
 » show all
Taxonomy
Reference
1  [PMID:5846992]
  Authors
Friedman S, Kaufman S.
  Title
3,4-dihydroxyphenylethylamine beta-hydroxylase. Physical properties, copper content, and role of copper in the catalytic acttivity.
  Journal
J. Biol. Chem. 240 (1965) 4763-73.
  Organism
Bos taurus [GN:bta]
Reference
2  [PMID:14416204]
  Authors
LEVIN EY, LEVENBERG B, KAUFMAN S.
  Title
The enzymatic conversion of 3,4-dihydroxyphenylethylamine to norepinephrine.
  Journal
J. Biol. Chem. 235 (1960) 2080-6.
  Organism
Bos taurus [GN:bta]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9013-38-1
DBGET integrated database retrieval system