KEGG   ENZYME: 1.14.17.4Help
Entry
EC 1.14.17.4                Enzyme                                 

Name
aminocyclopropanecarboxylate oxidase;
ACC oxidase;
ethylene-forming enzyme
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced ascorbate as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
1-aminocyclopropane-1-carboxylate oxygenase (ethylene-forming)
Reaction(IUBMB)
1-aminocyclopropane-1-carboxylate + ascorbate + O2 = ethylene + cyanide + dehydroascorbate + CO2 + 2 H2O [RN:R07214]
Reaction(KEGG)
Substrate
1-aminocyclopropane-1-carboxylate [CPD:C01234];
ascorbate [CPD:C00072];
O2 [CPD:C00007]
Product
ethylene [CPD:C06547];
cyanide [CPD:C00177];
dehydroascorbate [CPD:C05422];
CO2 [CPD:C00011];
H2O [CPD:C00001]
Comment
A nonheme iron enzyme. Requires CO2 for activity. In the enzyme from plants, the ethylene has signalling functions such as stimulation of fruit-ripening.
History
EC 1.14.17.4 created 2003
Pathway
Cysteine and methionine metabolism
Metabolic pathways
Biosynthesis of secondary metabolites
Orthology
K05933  
aminocyclopropanecarboxylate oxidase
Genes
ATH: 
ALY: 
CRB: 
EUS: 
BRP: 
CIT: 
CIC: 
TCC: 
GMX: 
PVU: 
MTR: 
CAM: 
FVE: 
PPER: 
PMUM: 
MDM: 
PXB: 
CSV: 
CMO: 
RCU: 
POP: 
POPTR_0002s07880g(POPTRDRAFT_643574) POPTR_0002s21750g(POPTRDRAFT_552732) POPTR_0004s00460g POPTR_0005s20530g(POPTRDRAFT_559288) POPTR_0006s15610g(POPTRDRAFT_762678) POPTR_0011s00970g(POPTRDRAFT_568162) POPTR_0014s15710g(POPTRDRAFT_573016)
VVI: 
SLY: 
SOT: 
OSA: 
DOSA: 
Os01t0580500-01(Os01g0580500) Os02t0771600-01(Os02g0771600) Os05t0149300-00(Os05g0149300) Os05t0149400-01(Os05g0149400) Os06t0573900-00(Os06g0573900) Os09t0451000-01(Os09g0451000) Os09t0451400-01(Os09g0451400) Os11t0186900-01(Os11g0186900)
OBR: 
BDI: 
SBI: 
SORBI_02g026280(SORBIDRAFT_02g026280) SORBI_03g026000(SORBIDRAFT_03g026000) SORBI_04g034520(SORBIDRAFT_04g034520) SORBI_05g005710(SORBIDRAFT_05g005710) SORBI_05g005720(SORBIDRAFT_05g005720) SORBI_09g003790(SORBIDRAFT_09g003790) SORBI_09g003800(SORBIDRAFT_09g003800) SORBI_10g022640(SORBIDRAFT_10g022640)
ZMA: 
SITA: 
PDA: 
MUS: 
ATR: 
s00017p00245170(AMTR_s00017p00245170) s00112p00098670(AMTR_s00112p00098670)
 » show all
Taxonomy
Reference
1  [PMID:7717997]
  Authors
Zhang Z, Schofield CJ, Baldwin JE, Thomas P, John P.
  Title
Expression, purification and characterization of 1-aminocyclopropane-1-carboxylate oxidase from tomato in Escherichia coli.
  Journal
Biochem. J. 307 ( Pt 1) (1995) 77-85.
Reference
2  [PMID:9398335]
  Authors
Zhang Z, Barlow JN, Baldwin JE, Schofield CJ.
  Title
Metal-catalyzed oxidation and mutagenesis studies on the iron(II) binding site of 1-aminocyclopropane-1-carboxylate oxidase.
  Journal
Biochemistry. 36 (1997) 15999-6007.
Reference
3
  Authors
Pirrung, M.C.
  Title
Ethylene biosynthesis from 1-aminocyclopropanecarboxylic acid.
  Journal
Acc. Chem. Res. 32 (1999) 711-718.
Reference
4  [PMID:11361015]
  Authors
Charng YY, Chou SJ, Jiaang WT, Chen ST, Yang SF.
  Title
The catalytic mechanism of 1-aminocyclopropane-1-carboxylic acid oxidase.
  Journal
Arch. Biochem. Biophys. 385 (2001) 179-85.
Reference
5  [PMID:11583172]
  Authors
Thrower JS, Blalock R 3rd, Klinman JP.
  Title
Steady-state kinetics of substrate binding and iron release in tomato ACC oxidase.
  Journal
Biochemistry. 40 (2001) 9717-24.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
98668-53-2

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