KEGG   ENZYME: 1.14.19.3Help
Entry
EC 1.14.19.3                Enzyme                                 
Name linoleoyl-CoA desaturase;
Delta6-desaturase;
Delta6-fatty acyl-CoA desaturase;
Delta6-acyl CoA desaturase;
fatty acid Delta6-desaturase;
fatty acid 6-desaturase;
linoleate desaturase;
linoleic desaturase;
linoleic acid desaturase;
linoleoyl CoA desaturase;
linoleoyl-coenzyme A desaturase;
long-chain fatty acid Delta6-desaturase
Class Oxidoreductases;
Acting on paired donors, with O2 as oxidant and incorporation or
reduction of oxygen. The oxygen incorporated need not be derived
from O2;
With oxidation of a pair of donors resulting in the reduction of O2
to two molecules of water
BRITE hierarchy
Sysname linoleoyl-CoA,hydrogen-donor:oxygen oxidoreductase
Reaction(IUBMB) linoleoyl-CoA + AH2 + O2 = gamma-linolenoyl-CoA + A + 2 H2O
[RN:R03814]
Reaction(KEGG) R03814;
(other) R07063 R07933
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Substrate linoleoyl-CoA [CPD:C02050];
AH2 [CPD:C00030];
O2 [CPD:C00007]
Product gamma-linolenoyl-CoA [CPD:C03035];
A [CPD:C00028];
H2O [CPD:C00001]
Cofactor Iron [CPD:C00023]
Comment An iron protein. The rat liver enzyme is an enzyme system involving
cytochrome b5 and EC 1.6.2.2, cytochrome-b5 reductase.
Pathway PATH: ec00591  Linoleic acid metabolism
PATH: ec01100  Metabolic pathways
Orthology KO: K00508  linoleoyl-CoA desaturase
Genes TET: TTHERM_00196130
XCC: XCC3878
XCB: XC_3964
XCV: XCV4052
XAC: XAC3959
XOO: XOO4446
XOM: XOO_4186
SML: Smlt2831
ACB: A1S_2458
CVI: CV_1644(desD) CV_2452
ADE: Adeh_1021
MTU: Rv3229c
MTC: MT3326
MRA: MRA_3270
MTF: TBFG_13258
MBO: Mb3258c
MBB: BCG_3259c(desA3_1) BCG_3352c(desA3_2)
MBT: JTY_3254(desA3_1)
MPA: MAP3343c
MAV: MAV_4192 MAV_5167
MSM: MSMEG_1886
MUL: MUL_2564(desA3_1) MUL_2565(desA3)
MVA: Mvan_1768
MGI: Mflv_4698
MAB: MAB_2148 MAB_3548c
MMC: Mmcs_1359
MKM: Mkms_1377
MJL: Mjls_1393
MMI: MMAR_1315(desA3) MMAR_1316(desA3_1)
CDI: DIP0704
NFA: nfa46040
RHA: RHA1_ro01408 RHA1_ro06336
RER: RER_21800(desA3)
ROP: ROP_63970(desA3)
SGR: SGR_418
ART: Arth_0195
AAU: AAur_3180
ACH: Achl_3230
KRH: KRH_03150
MLU: Mlut_22420
NCA: Noca_3667
FRE: Franean1_6974
FAL: FRAAL6454(desA)
STP: Strop_2077
SAQ: Sare_2220
CHU: CHU_3762 CHU_3764
FJO: Fjoh_1748
SYN: sll0262(desD(des6))
Taxonomy
Reference
  Authors
  Title

  Journal
  Organism
 1  [PMID:7212717]
Okayasu T, Nagao M, Ishibashi T, Imai Y.
Purification and partial characterization of linoleoyl-CoA
desaturase from rat liver microsomes.
Arch. Biochem. Biophys. 206 (1981) 21-8.
Rattus norvegicus [GN:rno]
Other DBs ExplorEnz - The Enzyme Database: 1.14.19.3
IUBMB Enzyme Nomenclature: 1.14.19.3
ExPASy - ENZYME nomenclature database: 1.14.19.3
BRENDA, the Enzyme Database: 1.14.19.3
CAS: 9082-66-0
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