| Entry |
|
|---|
| Name |
(S)-stylopine synthase;
(S)-cheilanthifoline oxidase (methylenedioxy-bridge-forming) |
|---|
| Class |
Oxidoreductases;
Acting on paired donors, with O2 as oxidant and incorporation or
reduction of oxygen. The oxygen incorporated need not be derived
from O2;
With NADH or NADPH as one donor, and the other dehydrogenated
 |
|---|
| Sysname |
(S)-cheilanthifoline,NADPH:oxygen oxidoreductase
(methylenedioxy-bridge-forming) |
|---|
| Reaction(IUBMB) |
(S)-cheilanthifoline + NADPH + H+ + O2 = (S)-stylopine + NADP+ + 2
H2O [RN:R04690] |
|---|
| Reaction(KEGG) |
R04690
 |
|---|
| Substrate |
(S)-cheilanthifoline [CPD:C05174];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007] |
|---|
| Product |
(S)-stylopine [CPD:C05175];
NADP+ [CPD:C00006];
H2O [CPD:C00001] |
|---|
| Comment |
A heme-thiolate enzyme (P-450) catalysing an oxidative reaction that
does not incorporate oxygen into the product. Forms the second
methylenedioxy bridge of the protoberberine alkaloid stylopine from
oxidative ring closure of adjacent phenolic and methoxy groups of
cheilanthifoline. |
|---|
| Pathway |
PATH: ec00950 Isoquinoline alkaloid biosynthesis
PATH: ec01063 Biosynthesis of alkaloids derived from shikimate
pathway
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K13395 cytochrome P450, family 719, subfamily A (stylopine
synthase) |
|---|
Reference
Authors
Title
Journal
|
1
Bauer, W. and Zenk, M.H.
Two methylenedioxy bridge-forming cytochrome P-450 dependent enzymes
are involved in (S)-stylopine biosynthesis.
Phytochemistry 30 (1991) 2953-2961. |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.14.21.1
IUBMB Enzyme Nomenclature: 1.14.21.1
ExPASy - ENZYME nomenclature database: 1.14.21.1
BRENDA, the Enzyme Database: 1.14.21.1
CAS: 138791-29-4 |
|---|
