| Entry |
|
|---|
| Name |
steroid 21-monooxygenase;
steroid 21-hydroxylase;
21-hydroxylase |
|---|
| Class |
Oxidoreductases;
Acting on paired donors, with O2 as oxidant and incorporation or
reduction of oxygen. The oxygen incorporated need not be derived
from O2;
Miscellaneous
 |
|---|
| Sysname |
steroid,hydrogen-donor:oxygen oxidoreductase (21-hydroxylating) |
|---|
| Reaction(IUBMB) |
a steroid + AH2 + O2 = a 21-hydroxysteroid + A + H2O [RN:R02130] |
|---|
| Reaction(KEGG) |
R02130 > R02213 R02838 R03326 R03784 R03849 R04675
 |
|---|
| Substrate |
steroid [CPD:C00377];
AH2 [CPD:C00030];
O2 [CPD:C00007] |
|---|
| Product |
21-hydroxysteroid [CPD:C02506];
A [CPD:C00028];
H2O [CPD:C00001] |
|---|
| Cofactor |
Heme [CPD:C00032];
Flavin [CPD:C00176] |
|---|
| Comment |
An enzyme system involving a heme-thiolate protein (P-450) and
flavoprotein. |
|---|
| Pathway |
PATH: ec00140 Steroid hormone biosynthesis
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K00513 cytochrome P450, family 21, subfamily A (steroid
21-monooxygenase) |
|---|
| Genes |
HSA: 1589(CYP21A2)
PTR: 471972(CYP21A2)
MCC: 717020
MMU: 13079(Cyp21a1)
RNO: 24298(Cyp21a1)
CFA: 415124(CYP21A)
BTA: 281741(CYP21) 282425(CYP21A2)
SSC: 403337(SBAB-514B12.1)
ECB: 100059277
MDO: 100025565
GGA: 429828(CYP21)
XLA: 447267
DRE: 793249
 |
|---|
Reference
Authors
Title
Journal
|
1 [PMID:14934270]
DORFMAN RI, HAYANO M.
The action of adrenal homogenates on progesterone,
17-hydroxyprogesterone and 21-desoxycortisone.
Arch. Biochem. 36 (1952) 237-9. |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:13031650]
PLAGER JE, SAMUELS LT.
Synthesis of C14-17-hydroxy-11-desoxycorticosterone and
17-hydroxycorticosterone by fractionated extracts of adrenal
homogenates.
Arch. Biochem. Biophys. 42 (1953) 477-8.
Bos taurus [GN:bta] |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:13416221]
RYAN KJ, ENGEL LL.
Hydroxylation of steroids at carbon 21.
J. Biol. Chem. 225 (1957) 103-14.
Bos taurus [GN:bta] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.14.99.10
IUBMB Enzyme Nomenclature: 1.14.99.10
ExPASy - ENZYME nomenclature database: 1.14.99.10
BRENDA, the Enzyme Database: 1.14.99.10
CAS: 9029-68-9 |
|---|
