| Entry |
|
|---|
| Name |
estradiol 6beta-monooxygenase;
estradiol 6beta-hydroxylase |
|---|
| Class |
Oxidoreductases;
Acting on paired donors, with O2 as oxidant and incorporation or
reduction of oxygen. The oxygen incorporated need not be derived
from O2;
Miscellaneous
 |
|---|
| Sysname |
estradiol-17beta,hydrogen-donor:oxygen oxidoreductase
(6beta-hydroxylating) |
|---|
| Reaction(IUBMB) |
estradiol-17beta + AH2 + O2 = 6beta-hydroxyestradiol-17beta + A +
H2O [RN:R03086] |
|---|
| Reaction(KEGG) |
R03086
 |
|---|
| Substrate |
estradiol-17beta [CPD:C00951];
AH2 [CPD:C00030];
O2 [CPD:C00007] |
|---|
| Product |
6beta-hydroxyestradiol-17beta [CPD:C03935];
A [CPD:C00028];
H2O [CPD:C00001] |
|---|
| Pathway |
PATH: ec00140 Steroid hormone biosynthesis |
|---|
Reference
Authors
Title
Journal
|
1
Haines, W.J.
The biosynthesis of adrenal cortex hormones.
Recent Progr. Hormone Res. 7 (1952) 255-305. |
|---|
Reference
Authors
Title
Journal
|
2
Mueller, G.C. and Rumney, G.
Formation of 6beta-hydroxy and 6-keto derivatives of
estradiol-16-C14 by mouse liver microsomes.
J. Am. Chem. Soc. 79 (1957) 1004-1005. |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.14.99.11
IUBMB Enzyme Nomenclature: 1.14.99.11
ExPASy - ENZYME nomenclature database: 1.14.99.11
BRENDA, the Enzyme Database: 1.14.99.11
CAS: 9029-70-3 |
|---|
