| Entry |
|
|---|
| Name |
plasmanylethanolamine desaturase;
alkylacylglycerophosphoethanolamine desaturase;
alkylacylglycero-phosphorylethanolamine dehydrogenase;
dehydrogenase, alkyl-acylglycerophosphorylethanolamine;
1-O-alkyl-2-acyl-sn-glycero-3-phosphorylethanolamine desaturase;
1-O-alkyl 2-acyl-sn-glycero-3-phosphorylethanolamine desaturase |
|---|
| Class |
Oxidoreductases;
Acting on paired donors, with O2 as oxidant and incorporation or
reduction of oxygen. The oxygen incorporated need not be derived
from O2;
Miscellaneous
 |
|---|
| Sysname |
O-1-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine,hydrogen-donor:oxy
gen oxidoreductase |
|---|
| Reaction(IUBMB) |
O-1-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + AH2 + O2 =
O-1-alk-1-enyl-2-acyl-sn-glycero-3-phosphoethanolamine + A + 2 H2O
[RN:R04571] |
|---|
| Reaction(KEGG) |
R04571
 |
|---|
| Substrate |
O-1-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine [CPD:C04475];
AH2 [CPD:C00030];
O2 [CPD:C00007] |
|---|
| Product |
O-1-alk-1-enyl-2-acyl-sn-glycero-3-phosphoethanolamine [CPD:C04756];
A [CPD:C00028];
H2O [CPD:C00001] |
|---|
| Cofactor |
ATP [CPD:C00002];
Manganese [CPD:C00034];
Magnesium [CPD:C00305] |
|---|
| Comment |
Requires NADPH or NADH. May involve cytochrome b5. Requires Mg2+ and
ATP. |
|---|
| Pathway |
PATH: ec00565 Ether lipid metabolism
PATH: ec01100 Metabolic pathways |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:4144394]
Paltauf F, Holasek A.
Enzymatic synthesis of plasmalogens. Characterization of the
1-O-alkyl-2-acyl-8n-glycero-3-phosphorylethanolamine desaturase from
mucosa of hamster small intestine.
J. Biol. Chem. 248 (1973) 1609-15.
Mesocricetus auratus |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:4403444]
Wykle RL, Blank ML, Malone B, Snyder F.
Evidence for a mixed function oxidase in the biosynthesis of
ethanolamine plasmalogens from
1-alkyl-2-acyl-sn-glycero-3-phosphorylethanolamine.
J. Biol. Chem. 247 (1972) 5442-7.
Rattus norvegicus [GN:rno] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.14.99.19
IUBMB Enzyme Nomenclature: 1.14.99.19
ExPASy - ENZYME nomenclature database: 1.14.99.19
BRENDA, the Enzyme Database: 1.14.99.19
CAS: 39391-13-4 |
|---|
