KEGG   ENZYME: 1.14.99.34Help
Entry
EC 1.14.99.34               Enzyme                                 

Name
monoprenyl isoflavone epoxidase;
monoprenyl isoflavone monooxygenase;
7-O-methylluteone:O2 oxidoreductase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
Miscellaneous
BRITE hierarchy
Sysname
7-O-methylluteone,NADPH:O2 oxidoreductase
Reaction(IUBMB)
7-O-methylluteone + NADPH + H+ + O2 = dihydrofurano derivatives + NADP+ + H2O [RN:R05741]
Reaction(KEGG)
Substrate
7-O-methylluteone [CPD:C07290];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
dihydrofurano derivative [CPD:C07291];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Comment
A flavoprotein (FAD) with high specificity for monoprenyl isoflavone. The product of the prenyl epoxidation reaction contains an oxygen atom derived from O2, but not from H2O. It is slowly and nonenzymically converted into the corresponding dihydrofurano derivative. The enzyme in the fungus Botrytis cinerea is induced by the substrate analogue, 6-prenylnaringenin.
History
EC 1.14.99.34 created 2000
Reference
1
  Authors
Tanaka, M. and Tahara, S.
  Title
FAD-dependent epoxidase as a key enzyme in fungal metabolism of prenylated flavonoids.
  Journal
Phytochemistry 46 (1997) 433-439.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
198496-86-5

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