| Entry |
|
|---|
| Name |
steroid 17alpha-monooxygenase;
steroid 17alpha-hydroxylase;
cytochrome P-45017alpha;
cytochrome P-450 (P-45017alpha,lyase);
17alpha-hydroxylase-C17,20 lyase |
|---|
| Class |
Oxidoreductases;
Acting on paired donors, with O2 as oxidant and incorporation or
reduction of oxygen. The oxygen incorporated need not be derived
from O2;
Miscellaneous
 |
|---|
| Sysname |
steroid,hydrogen-donor:oxygen oxidoreductase (17alpha-hydroxylating) |
|---|
| Reaction(IUBMB) |
a steroid + AH2 + O2 = a 17alpha-hydroxysteroid + A + H2O
[RN:R02131] |
|---|
| Reaction(KEGG) |
R02131 > R02211 R03783 R04852 R04853;
(other) R08517 R08518
 |
|---|
| Substrate |
steroid [CPD:C00377];
AH2 [CPD:C00030];
O2 [CPD:C00007] |
|---|
| Product |
17alpha-hydroxysteroid [CPD:C03336];
A [CPD:C00028];
H2O [CPD:C00001] |
|---|
| Cofactor |
NADH [CPD:C00004];
NADPH [CPD:C00005];
Heme [CPD:C00032] |
|---|
| Comment |
Requires NAD(P)H and P-450. |
|---|
| Pathway |
PATH: ec00140 Steroid hormone biosynthesis
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K00512 cytochrome P450, family 17, subfamily A (steroid
17alpha-monooxygenase) |
|---|
| Genes |
HSA: 1586(CYP17A1)
PTR: 450141(CYP17A1)
MCC: 678693(CYP17A1)
MMU: 13074(Cyp17a1)
RNO: 25146(Cyp17a1)
CFA: 477807
BTA: 281739(CYP17) 782561(CYP17A1) 784256
SSC: 403330(CYP17A1)
ECB: 100034232(CYP17A1)
OAA: 100080906
GGA: 425056(CYP17A1)
XLA: 100036774
XTR: 100145650
DRE: 399692(cyp17a1)
BFO: BRAFLDRAFT_94132
 |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:13549484]
LYNN WS Jr, BROWN RH.
The conversion of progesterone to androgens by testes.
J. Biol. Chem. 232 (1958) 1015-30.
Rattus norvegicus [GN:rno], Cavia porcellus |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:6966286]
Yoshida KI, Oshima H, Troen P.
Studies of the human testis. XIII. Properties of nicotinamide
adenine dinucleotide (reduced form)-linked 17 alpha-hydroxylation.
J. Clin. Endocrinol. Metab. 50 (1980) 895-9.
Homo sapiens [GN:hsa] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.14.99.9
IUBMB Enzyme Nomenclature: 1.14.99.9
ExPASy - ENZYME nomenclature database: 1.14.99.9
BRENDA, the Enzyme Database: 1.14.99.9
CAS: 9029-67-8 |
|---|
