KEGG   ENZYME: 1.16.1.3Help
Entry
EC 1.16.1.3                 Enzyme                                 
Name aquacobalamin reductase;
aquocobalamin reductase;
vitamin B12a reductase;
NADH-linked aquacobalamin reductase;
B12a reductase;
NADH2:cob(III)alamin oxidoreductase
Class Oxidoreductases;
Oxidizing metal ions;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname cob(II)alamin:NAD+ oxidoreductase
Reaction(IUBMB) 2 cob(II)alamin + NAD+ = 2 aquacob(III)alamin + NADH + H+
[RN:R00097]
Reaction(KEGG) R00097
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Substrate cob(II)alamin [CPD:C00541];
NAD+ [CPD:C00003]
Product aquacob(III)alamin [CPD:C00992];
NADH [CPD:C00004];
H+ [CPD:C00080]
Cofactor FAD [CPD:C00016]
Comment A flavoprotein.
Pathway PATH: ec00860  Porphyrin and chlorophyll metabolism
Orthology KO: K05368  aquacobalamin reductase / NAD(P)H-flavin reductase
Genes ECO: b3844(fre)
ECJ: JW3820(fre)
ECD: ECDH10B_4033(fre)
EBW: BWG_3520(fre)
ECE: Z5365(fre)
ECS: ECs4772(fre)
ECF: ECH74115_5283(fre)
ETW: ECSP_4897(fre)
ECG: E2348C_4156(fre)
ECC: c4791(fre)
ECI: UTI89_C4429(fre)
ECP: ECP_4057
ECV: APECO1_2613(fre)
ECW: EcE24377A_4363(fre)
ECX: EcHS_A4066(fre)
ECM: EcSMS35_4225(fre)
ECY: ECSE_4130(fre)
ECL: EcolC_4166(fre)
ECK: EC55989_4319(fre)
ECQ: ECED1_4546(fre)
ECR: ECIAI1_4037(fre)
ECT: ECIAI39_3153(fre)
ECZ: ECS88_4292(fre)
EUM: ECUMN_4368(fre)
ELF: LF82_0736(fre)
EBL: B21_03684(fre)
EBD: ECBD_4181
EBR: ECB_03735(fre)
EOH: ECO103_4321(fre)
EOI: ECO111_4670(fre)
EOJ: ECO26_4743(fre)
EFE: EFER_3638(fre)
STY: STY3580(fre)
STT: t3318(fre)
SPT: SPA3820(fre)
SEK: SSPA3558(fre)
SPQ: SPAB_04936(fre)
SEI: SPC_4087(ubiB)
SEC: SC3877(fre)
SEH: SeHA_C4306(fre)
SEE: SNSL254_A4259(fre)
SEW: SeSA_A4187(fre)
SEA: SeAg_B4210(fre)
SED: SeD_A4366(fre)
SEG: SG3472(fre)
SET: SEN3774(fre)
SES: SARI_03678(fre)
STM: STM3979(fre)
YPE: YPO3768(fre)
YPK: y0462(fre)
YPM: YP_3280(fre)
YPA: YPA_3438(fre)
YPN: YPN_0196
YPG: YpAngola_A1910(fre)
YPP: YPDSF_3388(fre)
YPS: YPTB0265(fre)
YPI: YpsIP31758_0281(fre)
YPY: YPK_3935(fre)
YPB: YPTS_0281(fre)
YEN: YE0266(fre)
SFL: SF3920(fre)
SFX: S3832(fre)
SFV: SFV_3656(fre)
SSN: SSON_4017(fre)
SBO: SBO_3856(fre)
SBC: SbBS512_E4314(fre)
SDY: SDY_3901(fre)
ECA: ECA0206(fre)
PCT: PC1_4046
PWA: Pecwa_4237
ETA: ETA_02440(fre)
PLU: plu4404(fre)
PAY: PAU_03875(fre)
SGL: SG0117(fre)
ENT: Ent638_3951(fre)
ESA: ESA_03717(fre)
CTU: Ctu_02740(fre)
KPN: KPN_04338(fre)
KPE: KPK_5335(fre)
KPU: KP1_0201(fre)
CKO: CKO_00185(fre)
SPE: Spro_0259(fre)
PMR: PMI3547(fre)
EIC: NT01EI_0151
ETR: ETAE_0158(fre)
HDE: HDEF_2108(fre)
DDA: Dd703_3753
DDC: Dd586_0198
DZE: Dd1591_3905
VCH: VC0312(fre)
VCO: VC0395_A2704(fre)
VCM: VCM66_0296
VCJ: VCD_001310
VVU: VV1_0933(fre)
VVY: VV3177(fre)
VPA: VP2995(fre)
VHA: VIBHAR_00332(fre)
VSP: VS_3067(fre)
VEX: VEA_002102
VFI: VF_0062(fre)
VFM: VFMJ11_0060(fre)
VSA: VSAL_I0152(fre)
PPR: PBPRA3536(fre)
SON: SO_0504(fre)
SDN: Sden_3058(fre)
SFR: Sfri_3390(fre)
SAZ: Sama_0425(fre)
SBL: Sbal_0464
SBM: Shew185_3860(fre)
SBN: Sbal195_3986(fre)
SBP: Sbal223_3804(fre)
SLO: Shew_0359
SPC: Sputcn32_3353(fre)
SSE: Ssed_0504(fre)
SPL: Spea_0520(fre)
SHE: Shewmr4_0505(fre)
SHM: Shewmr7_3526(fre)
SHN: Shewana3_0505(fre)
SHW: Sputw3181_0588
SHL: Shal_0584(fre)
SWD: Swoo_4445(fre)
SWP: swp_4642(fre)
ILO: IL2359(fre)
CPS: CPS_0178(fre)
PHA: PSHAa0104(fre)
AMC: MADE_03476(fre)
PIN: Ping_3187
AHA: AHA_0102(fre)
ASA: ASA_4290(fre)
TAU: Tola_2976
BCI: BCI_0060(fre)
Taxonomy
Reference
  Authors
  Title

  Journal
  Organism
 1  [PMID:4390543]
Walker GA, Murphy S, Huennekens FM.
Enzymatic conversion of vitamin B 12a to adenosyl-B 12: evidence for
the existence of two separate reducing systems.
Arch. Biochem. Biophys. 134 (1969) 95-102.
Clostridium tetanomorphum
Other DBs ExplorEnz - The Enzyme Database: 1.16.1.3
IUBMB Enzyme Nomenclature: 1.16.1.3
ExPASy - ENZYME nomenclature database: 1.16.1.3
BRENDA, the Enzyme Database: 1.16.1.3
CAS: 37256-39-6
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