KEGG   ENZYME: 1.16.1.8Help
Entry
EC 1.16.1.8                 Enzyme                                 
Name
[methionine synthase] reductase;
methionine synthase cob(II)alamin reductase (methylating);
methionine synthase reductase;
[methionine synthase]-cobalamin methyltransferase (cob(II)alamin reducing)
Class
Oxidoreductases;
Oxidizing metal ions;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
[methionine synthase]-methylcob(I)alamin,S-adenosylhomocysteine:NADP+ oxidoreductase
Reaction(IUBMB)
2 [methionine synthase]-methylcob(I)alamin + 2 S-adenosylhomocysteine + NADP+ = 2 [methionine synthase]-cob(II)alamin + NADPH + H+ + 2 S-adenosyl-L-methionine [RN:R05182]
Reaction(KEGG)
Substrate
[methionine synthase]-methylcob(I)alamin [CPD:C06410];
S-adenosylhomocysteine [CPD:C00021];
NADP+ [CPD:C00006]
Product
[methionine synthase]-cob(II)alamin [CPD:C06409];
NADPH [CPD:C00005];
H+ [CPD:C00080];
S-adenosyl-L-methionine [CPD:C00019]
Comment
In humans, the enzyme is a flavoprotein containing FAD and FMN. The substrate of the enzyme is the inactivated [Co(II)] form of EC 2.1.1.13, methionine synthase. Electrons are transferred from NADPH to FAD to FMN. Defects in this enzyme lead to hereditary hyperhomocysteinemia.
Orthology
K00597  
[methionine synthase] reductase
Genes
HSA: 
4552(MTRR)
PTR: 
461717(MTRR)
PPS: 
100990677(MTRR)
GGO: 
101138335(MTRR)
PON: 
100174319(MTRR)
MCC: 
100430789(MTRR)
MMU: 
210009(Mtrr)
RNO: 
290947(Mtrr)
CFA: 
478623(MTRR)
AML: 
100484655(MTRR)
FCA: 
101098359(MTRR)
BTA: 
507991(MTRR)
SSC: 
100516580(MTRR)
ECB: 
100071310
MDO: 
100013254(MTRR)
SHR: 
100923220(MTRR)
OAA: 
100089744(MTRR)
GGA: 
428502(MTRR)
MGP: 
100540427
TGU: 
100228556(MTRR)
ACS: 
100563923(mtrr)
XTR: 
733716(mtrr)
DRE: 
560667(mtrr)
TRU: 
101070210
OLA: 
101167253 101167498
BFO: 
BRAFLDRAFT_282133
CIN: 
100182690
SPU: 
581957
DME: 
Dmel_CG14882
DAN: 
Dana_GF18497
DER: 
Dere_GG17003
DWI: 
Dwil_GK13220
DGR: 
Dgri_GH19344
AGA: 
AgaP_AGAP001789
AAG: 
AaeL_AAEL000502
TCA: 
655238
PHU: 
Phum_PHUM317650
ISC: 
IscW_ISCW006522
CEL: 
CELE_C01G6.6(mtrr-1)
CBR: 
CBG00882(Cbr-tag-165)
BMY: 
Bm1_35655
TSP: 
Tsp_01287
SMM: 
Smp_034220
NVE: 
NEMVE_v1g167483
HMG: 
100207049
TAD: 
TRIADDRAFT_21300
AQU: 
100635303
MBR: 
MONBRDRAFT_34058
NGR: 
NAEGRDRAFT_59563(FM177)
DPP: 
DICPUDRAFT_43883
PIF: 
PITG_06954
 » show all
Taxonomy
Reference
1  [PMID:9501215]
  Authors
Leclerc D, Wilson A, Dumas R, Gafuik C, Song D, Watkins D, Heng HH, Rommens JM, Scherer SW, Rosenblatt DS, Gravel RA.
  Title
Cloning and mapping of a cDNA for methionine synthase reductase, a flavoprotein defective in patients with homocystinuria.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 95 (1998) 3059-64.
  Organism
Homo sapiens [GN:hsa]
Reference
2  [PMID:11466310]
  Authors
Olteanu H, Banerjee R.
  Title
Human methionine synthase reductase, a soluble P-450 reductase-like dual flavoprotein, is sufficient for NADPH-dependent methionine synthase activation.
  Journal
J. Biol. Chem. 276 (2001) 35558-63.
  Organism
Homo sapiens [GN:hsa]
Reference
3  [PMID:12416982]
  Authors
Olteanu H, Munson T, Banerjee R.
  Title
Differences in the efficiency of reductive activation of methionine synthase and exogenous electron acceptors between the common polymorphic variants of human methionine synthase reductase.
  Journal
Biochemistry. 41 (2002) 13378-85.
  Organism
Homo sapiens [GN:hsa]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
207004-87-3
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