| Entry |
|
|---|
| Name |
cob(II)yrinic acid a,c-diamide reductase;
cob(II)yrinic acid-a,c-diamide:FMN oxidoreductase (incorrect) |
|---|
| Class |
Oxidoreductases;
Oxidizing metal ions;
With a flavin as acceptor
 |
|---|
| Sysname |
cob(I)yrinic acid-a,c-diamide:FMN oxidoreductase |
|---|
| Reaction(IUBMB) |
2 cob(I)yrinic acid a,c-diamide + FMN + 2 H+ = 2 cob(II)yrinic acid
a,c-diamide + FMNH2 [RN:R05218] |
|---|
| Reaction(KEGG) |
R05218
 |
|---|
| Substrate |
cob(I)yrinic acid a,c-diamide [CPD:C06505];
FMN [CPD:C00061];
H+ [CPD:C00080] |
|---|
| Product |
cob(II)yrinic acid a,c-diamide [CPD:C06504];
FMNH2 [CPD:C01847] |
|---|
| Comment |
This enzyme also catalyses the reduction of cob(II)yric acid,
cob(II)inamide, cob(II)inamide phosphate, GDP-cob(II)inamide and
cob(II)alamin although cob(II)yrinic acid a,c-diamide is thought to
be the physiological substrate [1]. Also uses FAD and NADH but not
NADPH. |
|---|
| Pathway |
PATH: ec00860 Porphyrin and chlorophyll metabolism
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K04719 cob(II)yrinic acid a,c-diamide reductase |
|---|
| Genes |
PYO: PY07748
VSP: VS_II1157
PAE: PA1274
PAU: PA14_47750
PAP: PSPA7_4116
PAG: PLES_40381
PPU: PP_1674
PPF: Pput_4045
PPG: PputGB1_1273
PPW: PputW619_1233
PST: PSPTO_1710
PSB: Psyr_3679
PSP: PSPPH_3700
PFL: PFL_4429
PFO: Pfl01_1643
PFS: PFLU4489
PEN: PSEEN1380
PMY: Pmen_1752
PSA: PST_1293
AVN: Avin_33110
SPL: Spea_0684
SHL: Shal_0741
SWD: Swoo_1863
SWP: swp_4403
CPS: CPS_2468
MCA: MCA2289
HCH: HCH_06460
MMW: Mmwyl1_1437
CVI: CV_1555
RSO: RS03753(RSp0614)
RME: Rmet_2213
BMA: BMA2051
BMV: BMASAVP1_A0862
BML: BMA10229_A2694
BMN: BMA10247_1916
BPS: BPSL2735
BPM: BURPS1710b_3222
BPL: BURPS1106A_3208
BPD: BURPS668_3169(bluB)
BPR: GBP346_A3349(bluB)
BTE: BTH_I1401
BVI: Bcep1808_0761
BUR: Bcep18194_A3917
BCN: Bcen_0341
BCH: Bcen2424_0824
BCM: Bcenmc03_0794
BCJ: BCAL3180
BAM: Bamb_0704
BAC: BamMC406_0721
BMU: Bmul_2559
BMJ: BMULJ_00679
BXE: Bxe_B1657
BPH: Bphy_3158
BPY: Bphyt_4995
BGL: bglu_1g06950
RFR: Rfer_2617
POL: Bpro_2763
PNA: Pnap_2149
AAV: Aave_1544
AJS: Ajs_3177
DAC: Daci_2803
DIA: Dtpsy_2528
VAP: Vapar_2554
CTT: CtCNB1_1849
MPT: Mpe_B0452(cysG) Mpe_B0487(cysG)
HAR: HEAR0425
MMS: mma_2554
EBA: ebA4029
DAR: Daro_0141
TMZ: Tmz1t_1140
TBD: Tbd_2717
MFA: Mfla_0115
MMB: Mmol_0273
MEI: Msip34_0147
APP: CAP2UW1_3912
MLO: mll7468
SME: SMc00166
SMD: Smed_1562
ATU: Atu1654
ATC: AGR_C_3047
ARA: Arad_3252
AVI: Avi_2042
RET: RHE_CH02368(ypch00782)
REC: RHECIAT_CH0002455
RLE: RL2681
RLT: Rleg2_1996
RLG: Rleg_2211
RHI: NGR_c16920(bluB)
BME: BMEII0246
BMI: BMEA_B1040(bluB)
BMF: BAB2_1015
BMB: BruAb2_0994
BMC: BAbS19_II09410
BMS: BRA1054
BMT: BSUIS_B1050(bluB)
BCS: BCAN_B1076(bluB)
BMR: BMI_II1055
OAN: Oant_1328
BJA: bll3254
BRA: BRADO4896
BBT: BBta_3155
RPA: RPA0711
RPB: RPB_0743
RPC: RPC_3749
RPD: RPD_0641
RPE: RPE_2232
RPT: Rpal_0782
XAU: Xaut_2810
AZC: AZC_4661
MEX: Mext_2003
MEA: Mex_1p1981
MDI: METDI2769
MRD: Mrad2831_1022
MET: M446_3671
MPO: Mpop_1959
MCH: Mchl_2280 Mchl_5732
MNO: Mnod_4520
BID: Bind_0168
MSL: Msil_1629
SIL: SPO3254(bluB)
SIT: TM1040_2608
RSP: RSP_3218
RSH: Rsph17029_3956
RSQ: Rsph17025_3598
RSK: RSKD131_3398
RDE: RD1_3815(bluB)
PDE: Pden_2527
DSH: Dshi_0347(bluB)
NAR: Saro_0330
GBE: GbCGDNIH1_1100
GDI: GDI_0656
GDJ: Gdia_1350
APT: APA01_22470
RRU: Rru_A3536
RCE: RC1_3717(bluB)
MAG: amb1227
MGM: Mmc1_1683
LSP: Bsph_2918
BBE: BBR47_15030
MTU: Rv0306
MTC: MT0319(bluB)
MRA: MRA_0315
MTF: TBFG_10311
MTB: TBMG_00310(TBMG_00310.1)
MBO: Mb0314
MBB: BCG_0346
MBT: JTY_0316
MPA: MAP3792c
MAV: MAV_4857(bluB)
MSM: MSMEG_6053(bluB)
MUL: MUL_1218
MVA: Mvan_0381
MGI: Mflv_0353
MAB: MAB_3351c
MMC: Mmcs_4721
MJL: Mjls_5106
MMI: MMAR_0555
CKP: ckrop_1471
NFA: nfa46050
RER: RER_23360
ROP: ROP_64780
SCO: SCO1554(SCL11.10c)
SMA: SAV_6795(cobT2)
NCA: Noca_3407
TFU: Tfu_2222
FRA: Francci3_2878
FRE: Franean1_7192
SEN: SACE_0750
AMI: Amir_0603
STP: Strop_4448
SAQ: Sare_4962
CAI: Caci_2320
AFO: Afer_0271
TER: Tery_4461
CTE: CT0937
CPC: Cpar_1182
CCH: Cag_1013
CPH: Cpha266_1116
CPB: Cphamn1_1517
CLI: Clim_1065
PLT: Plut_1141
PPH: Ppha_1263
PAA: Paes_1270
CTS: Ctha_2225
DDR: Deide_2p01660
TTH: TT_P0018
TTJ: TTHB061
SSO: SSO2560
STO: ST0601
SAI: Saci_0250
SIS: LS215_2909
SIA: M1425_2744
SIM: M1627_2797
SID: M164_2727
SIY: YG5714_2923
SIN: YN1551_3111
MSE: Msed_1226
NMR: Nmar_1736
 |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:1429467]
Blanche F, Maton L, Debussche L, Thibaut D.
Purification and characterization of Cob(II)yrinic acid a,c-diamide
reductase from Pseudomonas denitrificans.
J. Bacteriol. 174 (1992) 7452-4.
Pseudomonas denitrificans |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:12195810]
Warren MJ, Raux E, Schubert HL, Escalante-Semerena JC.
The biosynthesis of adenosylcobalamin (vitamin B12).
Nat. Prod. Rep. 19 (2002) 390-412.
Propionibacterium freundenreichii |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.16.8.1
IUBMB Enzyme Nomenclature: 1.16.8.1
ExPASy - ENZYME nomenclature database: 1.16.8.1
BRENDA, the Enzyme Database: 1.16.8.1
CAS: 145539-93-1 |
|---|
