| Entry |
|
|---|
| Name |
CDP-4-dehydro-6-deoxyglucose reductase;
CDP-4-keto-6-deoxyglucose reductase;
cytidine diphospho-4-keto-6-deoxy-D-glucose reductase;
cytidine diphosphate 4-keto-6-deoxy-D-glucose-3-dehydrogenase;
CDP-4-keto-deoxy-glucose reductase;
CDP-4-keto-6-deoxy-D-glucose-3-dehydrogenase system;
NAD(P)H:CDP-4-keto-6-deoxy-D-glucose oxidoreductase |
|---|
| Class |
Oxidoreductases;
Acting on CH or CH2 groups;
With NAD+ or NADP+ as acceptor
 |
|---|
| Sysname |
CDP-4-dehydro-3,6-dideoxy-D-glucose:NAD(P)+ 3-oxidoreductase |
|---|
| Reaction(IUBMB) |
CDP-4-dehydro-3,6-dideoxy-D-glucose + NAD(P)+ + H2O =
CDP-4-dehydro-6-deoxy-D-glucose + NAD(P)H + H+ [RN:R03391 R03392] |
|---|
| Reaction(KEGG) |
R03391 R03392
 |
|---|
| Substrate |
CDP-4-dehydro-3,6-dideoxy-D-glucose [CPD:C04297];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006];
H2O [CPD:C00001] |
|---|
| Product |
CDP-4-dehydro-6-deoxy-D-glucose [CPD:C01219];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080] |
|---|
| Comment |
The enzyme consists of two proteins. One forms an enzyme-bound
adduct of the CDP-4-dehydro-6-deoxyglucose with pyridoxamine
phosphate, in which the 3-hydroxy group has been removed. The second
catalyses the reduction of this adduct by NAD(P)H and release of the
CDP-4-dehydro-3,6-dideoxy-D-glucose and pyridoxamine phosphate. |
|---|
| Pathway |
PATH: ec00520 Amino sugar and nucleotide sugar metabolism |
|---|
| Orthology |
KO: K00523 CDP-4-dehydro-6-deoxyglucose reductase |
|---|
| Genes |
STY: STY2303(rfbI)
STT: t0779(rfbI)
SPT: SPA0773(rfbI)
SEK: SSPA0727
SPQ: SPAB_00937
SEH: SeHA_C2319
SEW: SeSA_A2326
SEA: SeAg_B2218
SEG: SG2124(rfbI)
SET: SEN2089(rfbI)
STM: STM2093(rfbI)
YPE: YPO3116(ddhD)
YPK: y1067(ascD)
YPM: YP_0814(ddhD)
YPA: YPA_2609
YPN: YPN_0973
YPG: YpAngola_A2896(ddhD)
YPP: YPDSF_2752
YPS: YPTB0998(ddhD)
YPI: YpsIP31758_3052(ddhD)
YPY: YPK_3192
YPB: YPTS_1041
ECA: ECA1421(rfbI)
VFI: VF_0181(ddhD)
PAE: PA5236
PAU: PA14_69140(ubiB)
PAP: PSPA7_5979
PAG: PLES_56301
PPU: PP_5212
PPF: Pput_5121
PPG: PputGB1_5273
PPW: PputW619_5035
PST: PSPTO_5240
PSB: Psyr_0303
PSP: PSPPH_0290
PFL: PFL_5093 PFL_5979
PFO: Pfl01_5453
PFS: PFLU5897
PEN: PSEEN5329
PMY: Pmen_0311
PSA: PST_0545
AVN: Avin_42100 Avin_47390
MAQ: Maqu_0483
PIN: Ping_0772
TCX: Tcr_1691
AEH: Mlg_2530
HHA: Hhal_2281
TGR: Tgr7_0025
HCH: HCH_00287
CSA: Csal_0586
ABO: ABO_2315
MMW: Mmwyl1_3992
AFE: Lferr_0428
AFR: AFE_0252
RMA: Rmag_0764
KKO: Kkor_2590
NMA: NMA1571
NME: NMB1359
NMC: NMC1294
NMN: NMCC_1270
NMI: NMO_1195
NGO: NGO0659
NGK: NGK_1248
CVI: CV_3784(ubiB)
LHK: LHK_00427(ubiB)
RSO: RSc2434
RPI: Rpic_2702
RPF: Rpic12D_2312
REU: Reut_A2722 Reut_B3765
REH: H16_A3024 H16_B1877
RME: Rmet_2861 Rmet_3630
CTI: RALTA_A2498 RALTA_B1576
BMA: BMA1966
BMV: BMASAVP1_A0947
BML: BMA10229_A0878
BMN: BMA10247_0270
BPS: BPSL0927
BPM: BURPS1710b_1151(ascD)
BPL: BURPS1106A_0997
BPD: BURPS668_0990
BPR: GBP346_A0919
BTE: BTH_I0792
BVI: Bcep1808_2568
BUR: Bcep18194_A5822
BCN: Bcen_1879
BCH: Bcen2424_2490
BCM: Bcenmc03_2515
BCJ: BCAL2700
BAM: Bamb_2537
BAC: BamMC406_2408
BMU: Bmul_0805
BMJ: BMULJ_02455(ascD)
BXE: Bxe_A0829 Bxe_A1828
BPH: Bphy_0596
BPY: Bphyt_3138
BGL: bglu_1g28580
PNU: Pnuc_1724
PNE: Pnec_1442
BPE: BP0362 BP1817(ascD)
BPA: BPP1900(ascD) BPP4171
BBR: BB3210(ascD) BB4641
BPT: Bpet1991(ascD)
BAV: BAV2367
RFR: Rfer_3299
POL: Bpro_3790
PNA: Pnap_3204
AAV: Aave_1977
AJS: Ajs_2987
VEI: Veis_1766
DAC: Daci_2192
DIA: Dtpsy_2414
VAP: Vapar_1293
CTT: CtCNB1_3625
MPT: Mpe_A1127
HAR: HEAR0755
MMS: mma_0684(ascD)
LCH: Lcho_0668 Lcho_4353
NEU: NE0594
NET: Neut_1041
NMU: Nmul_A2686
EBA: ebA1776(ascD)
AZO: azo3496(ascD)
DAR: Daro_0279
TBD: Tbd_2563
MFA: Mfla_0031
MMB: Mmol_0162
MEI: Msip34_0030
APP: CAP2UW1_3606
NIS: NIS_0087
SCL: sce1842
RHI: NGR_b07390
OAN: Oant_3238
BID: Bind_3396
MSL: Msil_1650
RSK: RSKD131_1175
LFE: LAF_1034
MMI: MMAR_0128
ROP: ROP_20970 ROP_37440
GBR: Gbro_3552 Gbro_3633
AAU: AAur_pTC10250
FRA: Francci3_2519
AFO: Afer_1377
CPI: Cpin_0410
COC: Coch_0711
HMU: Hmuk_2731
 |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:4389672]
Pape H, Strominger JL.
Enzymatic synthesis of cytidine diphosphate 3,6-dideoxyhexoses. V.
Partial purification of the two protein components required for
introduction of the 3-deoxy group.
J. Biol. Chem. 244 (1969) 3598-604.
Salmonella typhimurium [GN:stm], Pasteurella pseudotuberculosis |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:4152100]
Rubenstein PA, Strominger JL.
Enzymatic synthesis of cytidine diphosphate 3,6-dideoxyhexoses. 8.
Mechanistic roles of enzyme E-1 and pyridoxamine 5'-phosphate in the
formation of cytidine diphosphate-4-keto-3,6-dideoxy-D-glucose from
cytidine diphosphate-4-keto-6-deoxy-D-glucose.
J. Biol. Chem. 249 (1974) 3776-81.
Salmonella typhimurium [GN:stm], Pasteurella pseudotuberculosis |
|---|
Reference
Authors
Title
Journal
|
3 [PMID:7826006]
Liu HW, Thorson JS.
Pathways and mechanisms in the biogenesis of novel deoxysugars by
bacteria.
Annu. Rev. Microbiol. 48 (1994) 223-56. |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.17.1.1
IUBMB Enzyme Nomenclature: 1.17.1.1
ExPASy - ENZYME nomenclature database: 1.17.1.1
BRENDA, the Enzyme Database: 1.17.1.1
CAS: 37256-87-4 |
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