KEGG   ENZYME: 1.17.1.2Help
Entry
EC 1.17.1.2                 Enzyme                                 
Name 4-hydroxy-3-methylbut-2-enyl diphosphate reductase;
isopentenyl-diphosphate:NADP+ oxidoreductase;
LytB;
(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase;
HMBPP reductase;
IspH;
LytB/IspH
Class Oxidoreductases;
Acting on CH or CH2 groups;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname isopentenyl-diphosphate:NAD(P)+ oxidoreductase
Reaction(IUBMB) (1) isopentenyl diphosphate + NAD(P)+ + H2O =
(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H + H+
[RN:R05884 R08209];
(2) dimethylallyl diphosphate + NAD(P)+ + H2O =
(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H + H+
[RN:R07219 R08210]
Reaction(KEGG) R05884 R07219 R08209 R08210
Show
Substrate isopentenyl diphosphate [CPD:C00129];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006];
H2O [CPD:C00001];
dimethylallyl diphosphate [CPD:C00235]
Product (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate [CPD:C11811];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment An iron-sulfur protein that contains either a [3Fe-4S] [6] or a
[4Fe-4S] [5] cluster. This enzyme comprises a system in which
ferredoxin is first reduced and subsequently reoxidized by an
NAD(P)+-dependent reductase. This is the last enzyme in the
non-mevalonate pathway for isoprenoid biosynthesis. This pathway,
also known as the 1-deoxy-D-xylulose 5-phosphate (DOXP) or as the
2-C-methyl-D-erythritol-4-phosphate (MEP) pathway, is found in most
bacteria and in plant chloroplasts. The enzyme acts in the reverse
direction, producing a 5:1 mixture of isopentenyl diphosphate and
dimethylallyl diphosphate.
Pathway PATH: ec00900  Terpenoid backbone biosynthesis
PATH: ec01062  Biosynthesis of terpenoids and steroids
PATH: ec01066  Biosynthesis of alkaloids derived from terpenoid and
               polyketide
PATH: ec01070  Biosynthesis of plant hormones
PATH: ec01100  Metabolic pathways
Orthology KO: K03527  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
Genes ATH: AT4G34350(HDR)
POP: POPTR_557296
RCU: RCOM_0938310
VVI: 100267479(GSVIVT00036436001)
OSA: 4334003(Os03g0731900)
SBI: SORBI_01g009140(SORBIDRAFT_01g009140)
PPP: PHYPADRAFT_194018 PHYPADRAFT_206243
CRE: CHLREDRAFT_59822(IDS1)
OLU: OSTLU_32979(IDS)
CME: CMJ152C
PFA: MAL1P1.35
PFD: PFDG_01560
PFH: PFHG_00328
PYO: PY01243
PCB: PC000598.01.0
PBE: PB000173.01.0
PVX: PVX_081535
TAN: TA17670
TPV: TP03_0674
BBO: BBOV_III001660
PTI: PHATRDRAFT_50808(HDR)
TPS: THAPSDRAFT_270376
ECO: b0029(ispH)
ECJ: JW0027(ispH)
ECD: ECDH10B_0030(ispH)
EBW: BWG_0027(ispH)
ECE: Z0034(ispH)
ECS: ECs0032(ispH)
ECF: ECH74115_0031(ispH)
ETW: ECSP_0030(ispH)
ECG: E2348C_0029(ispH)
ECC: c0033(ispH)
ECI: UTI89_C0031(ispH)
ECP: ECP_0027
ECV: APECO1_1954(ispH)
ECW: EcE24377A_0029(ispH)
ECX: EcHS_A0031(ispH)
ECM: EcSMS35_0027(ispH)
ECY: ECSE_0027(ispH)
ECL: EcolC_3626(ispH)
ECK: EC55989_0028(ispH)
ECQ: ECED1_0026(ispH)
ECR: ECIAI1_0030(ispH)
ECT: ECIAI39_0030(ispH)
ECZ: ECS88_0028(ispH)
EUM: ECUMN_0030(ispH)
ELF: LF82_1131(ispH)
EBL: B21_00032(ispH)
EBD: ECBD_3587
EBR: ECB_00033(ispH)
EOH: ECO103_0030(ispH)
EOI: ECO111_0029(ispH)
EOJ: ECO26_0029(ispH)
EFE: EFER_0022(ispH)
STY: STY0058(ispH)
STT: t0051(ispH)
SPT: SPA0050(ispH)
SEK: SSPA0046(ispH)
SPQ: SPAB_00059(ispH)
SEI: SPC_0052(lytB)
SEC: SC0043(ispH)
SEH: SeHA_C0053(ispH)
SEE: SNSL254_A0053(ispH)
SEW: SeSA_A0054(ispH)
SEA: SeAg_B0055(ispH)
SED: SeD_A0053(ispH)
SEG: SG0052(ispH)
SET: SEN0049(ispH)
SES: SARI_02945(ispH)
STM: STM0049(ispH)
YPE: YPO0477(ispH)
YPK: y3697(ispH)
YPM: YP_3702(ispH)
YPA: YPA_4071(ispH)
YPN: YPN_0350
YPG: YpAngola_A0787(ispH)
YPP: YPDSF_3154(ispH)
YPS: YPTB0620(ispH)
YPI: YpsIP31758_3457(ispH)
YPY: YPK_3585(ispH)
YPB: YPTS_0644(ispH)
YEN: YE0619(ispH)
SFL: SF0026(ispH)
SFX: S0028(ispH)
SFV: SFV_0023(ispH)
SSN: SSON_0034(ispH)
SBO: SBO_0028(ispH)
SBC: SbBS512_E0033(ispH)
SDY: SDY_0051(ispH)
ECA: ECA3873(ispH)
PCT: PC1_3650
PWA: Pecwa_3843
ETA: ETA_07150(ispH)
PLU: plu0594(ispH)
PAY: PAU_00559(ispH)
BUC: BU147(ispH)
BAS: BUsg140(ispH)
BAB: bbp137(lytB)
BAP: BUAP5A_145(lytB)
BAU: BUAPTUC7_146(lytB)
WBR: WGLp292(lytB)
SGL: SG0417(ispH)
ENT: Ent638_0587(ispH)
ESA: ESA_03309(ispH)
CTU: Ctu_06550(ispH)
KPN: KPN_00024(ispH)
KPE: KPK_4732(ispH)
KPU: KP1_0845(ispH)
CKO: CKO_03363(ispH)
SPE: Spro_0701(ispH)
PMR: PMI0018(ispH)
EIC: NT01EI_0682
ETR: ETAE_0585(ispH)
BPN: BPEN_124(ispH)
HDE: HDEF_0834(ispH)
DDA: Dd703_0590
DDC: Dd586_3585
DZE: Dd1591_0551
HIN: HI1007(ispH)
HIT: NTHI1182(ispH)
HIP: CGSHiEE_06935(ispH)
HIQ: CGSHiGG_08635(ispH)
HDU: HD0064(ispH)
HAP: HAPS_1306(ispH)
HSO: HS_0184(ispH)
HSM: HSM_0050(ispH)
PMU: PM1664(ispH)
MSU: MS1749(ispH)
APL: APL_1520(ispH)
APJ: APJL_1546(ispH)
APA: APP7_1580(ispH)
ASU: Asuc_1874(ispH)
AAP: NT05HA_2348
AAT: D11S_1928
XFA: XF2416(ispH)
XFT: PD1435
XFM: Xfasm12_1576(ispH)
XFN: XfasM23_1519(ispH)
XCC: XCC1157(ispH)
XCB: XC_3085(ispH)
XCA: xccb100_3181(ispH)
XCV: XCV1292(ispH)
XAC: XAC1256(ispH)
XOO: XOO1628(ispH)
XOM: XOO_1514(ispH)
XOP: PXO_05537(ispH)
SML: Smlt1342(ispH)
SMT: Smal_1127(ispH)
VCH: VC0685(ispH)
VCO: VC0395_A0217(ispH)
VCM: VCM66_0643(lytB)
VCJ: VCD_003635
VVU: VV1_0504(ispH)
VVY: VV0690(ispH)
VPA: VP0537(ispH)
VHA: VIBHAR_00983(ispH)
VSP: VS_0539(ispH)
VEX: VEA_004416
VFI: VF_0470(ispH)
VFM: VFMJ11_0469(ispH)
VSA: VSAL_I0583(ispH)
PPR: PBPRA0594(ispH)
PAE: PA4557(ispH)
PAU: PA14_60330(ispH)
PAP: PSPA7_3192(ispH2) PSPA7_5197(ispH)
PAG: PLES_49401(ispH)
PPU: PP_0606(ispH)
PPF: Pput_0647(ispH)
PPG: PputGB1_0652(ispH)
PPW: PputW619_4556(ispH)
PST: PSPTO_0809(ispH)
PSB: Psyr_0713(ispH)
PSP: PSPPH_0724(ispH)
PFL: PFL_5318(ispH)
PFO: Pfl01_4849(ispH)
PFS: PFLU0771(ispH)
PEN: PSEEN4689(ispH)
PMY: Pmen_0956
PSA: PST_0967(ispH)
CJA: CJA_3214(ispH)
AVN: Avin_11810(ispH)
PAR: Psyc_1722(ispH)
PCR: Pcryo_2002(ispH)
PRW: PsycPRwf_0578(ispH)
ACI: ACIAD3322(ispH)
ACB: A1S_3169
ABM: ABSDF0323(ispH)
ABY: ABAYE0313(ispH)
ABC: ACICU_03371(ispH)
ABN: AB57_3626(ispH)
ABB: ABBFA_000341(ispH)
SON: SO_3529(ispH)
SDN: Sden_2720(ispH)
SFR: Sfri_2887(ispH)
SAZ: Sama_0927(ispH)
SBL: Sbal_1057(ispH)
SBM: Shew185_1124(ispH)
SBN: Sbal195_1159(ispH)
SBP: Sbal223_3232(ispH)
SLO: Shew_1102(ispH)
SPC: Sputcn32_1062(ispH)
SSE: Ssed_1197(ispH)
SPL: Spea_1086(ispH)
SHE: Shewmr4_2954(ispH)
SHM: Shewmr7_3036(ispH)
SHN: Shewana3_3133(ispH)
SHW: Sputw3181_3103(ispH)
SHL: Shal_1134(ispH)
SWD: Swoo_1294(ispH)
SWP: swp_3724(ispH)
ILO: IL1125(lytB)
CPS: CPS_1211(ispH)
PHA: PSHAa0921(ispH)
PAT: Patl_3175(ispH)
SDE: Sde_2563
MAQ: Maqu_0865(ispH)
AMC: MADE_03027(ispH)
PIN: Ping_3268
MCA: MCA1815(ispH)
FTU: FTT_0833(ispH)
FTF: FTF0833(ispH)
FTW: FTW_1353(ispH)
FTL: FTL_0327(ispH)
FTH: FTH_0325(ispH)
FTA: FTA_0348(ispH)
FTM: FTM_0425(ispH)
FPH: Fphi_0475(ispH)
NOC: Noc_1744
AEH: Mlg_0854
HHA: Hhal_1834
TGR: Tgr7_3219
HNA: Hneap_2229
HCH: HCH_05930(ispH)
CSA: Csal_0484
ABO: ABO_0462(lytB)
MMW: Mmwyl1_4227
AHA: AHA_0685(ispH)
ASA: ASA_0687(ispH)
TAU: Tola_2952
AFE: Lferr_2858
AFR: AFE_3258(ispH)
BCI: BCI_0558(ispH)
RMA: Rmag_1023(ispH)
VOK: COSY_0924(ispH)
KKO: Kkor_1661
NMA: NMA0624(ispH)
NME: NMB1831(ispH)
NMC: NMC0385(ispH)
NMN: NMCC_0391(ispH)
NMI: NMO_0330(lytB)
NGO: NGO0072(ispH)
NGK: NGK_0106(ispH)
CVI: CV_3567(ispH)
LHK: LHK_00616(ispH)
RSO: RSc2442(ispH)
RPI: Rpic_2710(ispH)
RPF: Rpic12D_2320
REU: Reut_A2730(ispH) Reut_B4898(ispH)
REH: H16_A3031(ispH) H16_B2169(ispH)
RME: Rmet_2868(ispH) Rmet_4169(ispH)
CTI: RALTA_A2505(ispH) RALTA_B1952(ispH)
BMA: BMA2228(ispH) BMAA1962(ispH)
BMV: BMASAVP1_0980(ispH) BMASAVP1_A2644(ispH)
BML: BMA10229_1267 BMA10229_A1018
BMN: BMA10247_2097(ispH) BMA10247_A2242(ispH)
BPS: BPSL0919(ispH) BPSS2168(ispH)
BPM: BURPS1710b_1141(ispH) BURPS1710b_A1285(ispH)
BPL: BURPS1106A_0986(ispH) BURPS1106A_A2929(ispH)
BPD: BURPS668_0981(ispH) BURPS668_A3054(ispH)
BPR: GBP346_A0910(ispH_1)
BTE: BTH_I0783(ispH) BTH_II2243(ispH)
BVI: Bcep1808_2577 Bcep1808_3716
BUR: Bcep18194_A5831(ispH) Bcep18194_B0106(ispH)
BCN: Bcen_1888(ispH) Bcen_5308(ispH)
BCH: Bcen2424_2499 Bcen2424_5552
BCM: Bcenmc03_2524(ispH) Bcenmc03_4720(ispH)
BCJ: BCAL2710(ispH) BCAM2738(ispH)
BAM: Bamb_2546(ispH) Bamb_4876(ispH)
BAC: BamMC406_2417(ispH) BamMC406_5423(ispH)
BMU: Bmul_3253(ispH)
BMJ: BMULJ_02464(ispH) BMULJ_05272(ispH)
BXE: Bxe_A0820(ispH) Bxe_B0018(ispH)
BPH: Bphy_0587(ispH) Bphy_4130(ispH)
BPY: Bphyt_3146(ispH) Bphyt_7036(ispH)
BGL: bglu_1g28650 bglu_2g22170
PNU: Pnuc_1731
PNE: Pnec_1449
BPE: BP1237(ispH)
BPA: BPP1852(ispH)
BBR: BB3256(ispH)
BPT: Bpet3147(ispH)
BAV: BAV2403(ispH)
RFR: Rfer_3248(ispH)
POL: Bpro_0951(ispH)
PNA: Pnap_3337(ispH)
AAV: Aave_3771(ispH)
AJS: Ajs_3448(ispH)
VEI: Veis_1652(ispH)
DAC: Daci_1906(ispH)
DIA: Dtpsy_2775
VAP: Vapar_4031
CTT: CtCNB1_3819
MPT: Mpe_A2693(ispH)
HAR: HEAR2466(ispH)
MMS: mma_2549(ispH)
LCH: Lcho_0693(ispH)
NEU: NE0649(ispH)
NET: Neut_1903(ispH)
NMU: Nmul_A0089(ispH)
EBA: ebA4444(ispH)
AZO: azo1202(ispH)
DAR: Daro_3043
TMZ: Tmz1t_1778
TBD: Tbd_1860
MFA: Mfla_2431
MMB: Mmol_2279
MEI: Msip34_2604
APP: CAP2UW1_2543
HPY: HP0400(ispH)
HPJ: jhp0981(ispH)
HPA: HPAG1_0992(ispH)
HPS: HPSH_05405(ispH)
HPG: HPG27_997(ispH)
HPP: HPP12_1020(ispH)
HPB: HELPY_1025(ispH)
HHE: HH0138(ispH)
HAC: Hac_0458(ispH)
WSU: WS1310(ispH)
TDN: Suden_0872(ispH)
CJE: Cj0894c(ispH)
CJR: CJE0973(ispH)
CJJ: CJJ81176_0903(ispH)
CJU: C8J_0831(ispH)
CJD: JJD26997_0919(ispH)
CFF: CFF8240_1251(ispH)
CCV: CCV52592_0515(ispH)
CHA: CHAB381_0483(ispH)
CCO: CCC13826_1566(ispH)
CLA: Cla_1191(ispH)
ABU: Abu_2050(ispH)
SDL: Sdel_0612
NIS: NIS_0662(ispH)
SUN: SUN_0548(ispH)
NAM: NAMH_0910(ispH)
GSU: GSU2604(lytB)
GME: Gmet_0866
GUR: Gura_1466
GLO: Glov_2146
GBM: Gbem_3256
GEO: Geob_2363
GEM: GM21_0994
PCA: Pcar_1883(lytB)
PPD: Ppro_1349
DVU: DVU0055(ispH)
DVL: Dvul_2906
DVM: DvMF_2020
DDE: Dde_0390
DDS: Ddes_2083
DMA: DMR_26630(ispH)
DSA: Desal_2767
LIP: LI0728(lytB)
DBA: Dbac_3462
DRT: Dret_1078
DPS: DP2166
DOL: Dole_0383
DAL: Dalk_3710
DAT: HRM2_31890(ispH)
ADE: Adeh_1519
ACP: A2cp1_2436
AFW: Anae109_2302
ANK: AnaeK_2348
SAT: SYN_02454
SFU: Sfum_1812
WOL: WD1274(ispH)
WBM: Wbm0046(ispH)
WRI: WRi_012440(lytB)
WPI: WPa_0811(ispH)
AMA: AM804(ispH)
AMF: AMF_597(lytB)
ACN: ACIS_00535(ispH)
APH: APH_0380(ispH)
ERU: Erum5180(ispH)
ERW: ERWE_CDS_05430(ispH)
ERG: ERGA_CDS_05330(ispH)
ECN: Ecaj_0526(ispH)
ECH: ECH_0502(ispH)
NSE: NSE_0438(ispH)
NRI: NRI_0412(ispH)
PUB: SAR11_0124(lytB)
MLO: mlr7502(ispH)
MES: Meso_0748(ispH)
PLA: Plav_0686
SME: SMc00016(ispH)
SMD: Smed_0527(ispH)
ATU: Atu0774(ispH)
ATC: AGR_C_1414(lytB)
ARA: Arad_1244(ispH)
AVI: Avi_1052(ispH)
RET: RHE_CH00961(ispH)
REC: RHECIAT_CH0001056(ispH)
RLE: RL1030(ispH)
RLT: Rleg2_0611(ispH)
RLG: Rleg_0651
RHI: NGR_c05330(lytB)
BME: BMEI1459(ispH)
BMF: BAB1_0501(ispH)
BMB: BruAb1_0497(ispH)
BMC: BAbS19_I04640(ispH)
BMS: BR0475(ispH)
BMT: BSUIS_A0502(ispH)
BOV: BOV_0480(ispH)
BCS: BCAN_A0482(ispH)
BMR: BMI_I477(lytB)
OAN: Oant_0589(ispH)
BJA: bll3007(ispH) blr1314(ispH)
BRA: BRADO2632(ispH) BRADO6588(ispH)
BBT: BBta_0948(ispH) BBta_2972(ispH)
RPA: RPA3734(ispH) RPA4271(ispH)
RPB: RPB_1340(ispH) RPB_1729(ispH)
RPC: RPC_1726(ispH) RPC_4078(ispH)
RPD: RPD_3570(ispH) RPD_4030(ispH)
RPE: RPE_1816(ispH) RPE_4130(ispH)
RPT: Rpal_4255(ispH) Rpal_4751(ispH)
NWI: Nwi_2266(ispH) Nwi_2689(ispH)
NHA: Nham_2679(ispH) Nham_3745(ispH)
OCA: OCAR_6667(ispH) OCAR_7331(ispH)
BHE: BH04410(ispH)
BQU: BQ03600(ispH)
BBK: BARBAKC583_0406(ispH)
BTR: Btr_0655(ispH)
BGR: Bgr_04730(lytB)
XAU: Xaut_2355(ispH)
AZC: AZC_1468
MEX: Mext_2593(ispH)
MEA: Mex_1p2713(ispH)
MDI: METDI3326(ispH)
MRD: Mrad2831_4312(ispH)
MET: M446_6025(ispH)
MPO: Mpop_2621(ispH)
MCH: Mchl_2816(ispH)
MNO: Mnod_7157 Mnod_7260
BID: Bind_1904(ispH)
MSL: Msil_3225(ispH)
CCR: CC_3361
CCS: CCNA_03471
CAK: Caul_4391
PZU: PHZ_c2893
SIL: SPO3207(ispH)
SIT: TM1040_2569(ispH)
RSP: RSP_1666(ispH)
RSH: Rsph17029_0299(ispH)
RSQ: Rsph17025_2580(ispH)
RSK: RSKD131_3066
JAN: Jann_0507(ispH)
RDE: RD1_1355(ispH)
PDE: Pden_3619(ispH)
DSH: Dshi_0188(lytB)
MMR: Mmar10_2215
HNE: HNE_2713(ispH)
HBA: Hbal_1046
ZMO: ZMO0875
ZMN: Za10_0417
NAR: Saro_1087
SAL: Sala_1136
SWI: Swit_2692
ELI: ELI_01560
GOX: GOX0179
GBE: GbCGDNIH1_1875
ACR: Acry_1832
GDI: GDI_3102(ispH)
GDJ: Gdia_3265
APT: APA01_19770(lytB)
RRU: Rru_A0059
RCE: RC1_3654(ispH)
MAG: amb0764
MGM: Mmc1_3428
BSU: BSU25160(yqfP)
BHA: BH1382(ispH)
BAN: BA4511(ispH)
BAR: GBAA4511(ispH)
BAA: BA_4959
BAT: BAS4190(ispH)
BAH: BAMEG_4550(ispH)
BAI: BAA_4532(ispH)
BCA: BCE_4368(ispH)
BCZ: BCZK4038(ispH)
BCR: BCAH187_A4422(ispH)
BCB: BCB4264_A4405(ispH)
BCU: BCAH820_4310(ispH)
BCG: BCG9842_B0831(ispH)
BCQ: BCQ_4075(lytB)
BCX: BCA_4399(ispH)
BCY: Bcer98_3015(ispH)
BTK: BT9727_4028(ispH)
BTL: BALH_3881(ispH)
BWE: BcerKBAB4_4140(ispH)
BLI: BL03721(ispH)
BLD: BLi02695(ispH)
BCL: ABC1694(ispH)
BAY: RBAM_023470(ispH)
BPU: BPUM_2249(ispH)
GKA: GK2477(ispH)
GTN: GTNG_2414(ispH)
GWC: GWCH70_2409
GYM: GYMC10_5090
GYC: GYMC61_0162
AFL: Aflv_0861(ispH)
LMO: lmo1451(ispH)
LMF: LMOf2365_1470(ispH)
LMC: Lm4b_01461
LSP: Bsph_3685(ispH)
ESI: Exig_0836(ispH)
EAT: EAT1b_0585
MCL: MCCL_1209(lytB)
BBE: BBR47_49230(ispH)
PJD: Pjdr2_4780
AAC: Aaci_0997
CAC: CAC1847(lytB)
CPE: CPE1085(lytB)
CPF: CPF_1341(ispH)
CPR: CPR_1152(ispH)
CTC: CTC01314(lytB)
CNO: NT01CX_2096
CTH: Cthe_0714
CDF: CD1818(ispH)
CDC: CD196_1738(ispH)
CDL: CDR20291_1713(ispH)
CKL: CKL_1567
CKR: CKR_1457
AMT: Amet_2625
AOE: Clos_1562
STH: STH910(ispH)
SWO: Swol_1344
DSY: DSY2255
DHD: Dhaf_3385
DRM: Dred_1154
DAE: Dtox_2102
PTH: PTH_1619
DAU: Daud_1178
HMO: HM1_1931(ispH)
FMA: FMG_0826
EEL: EUBELI_00929
ERE: EUBREC_1637
TTE: TTE1352(lytB)
TEX: Teth514_1606
TPD: Teth39_1169
CHY: CHY_1925(lytB)
MTA: Moth_1329
CSC: Csac_1891
CPO: COPRO5265_0797
MPE: MYPE1330
MTU: Rv1110(ispH) Rv3382c(lytB1)
MTC: MT1141(ispH) MT3490(lytB-2)
MRA: MRA_1121(ispH) MRA_3422(lytB1)
MTF: TBFG_11132(ispH) TBFG_13416
MTB: TBMG_02873(TBMG_02873.1) TBMG_03431(TBMG_03431.1)
MBO: Mb1140(ispH) Mb3414c(lytB1)
MBB: BCG_1170(ispH) BCG_3451c(lytB1)
MBT: JTY_1143(lytB) JTY_3451(lytB1)
MLE: ML1938(ispH)
MLB: MLBr_01938(lytB2)
MPA: MAP2684c(ispH)
MAV: MAV_1230(ispH)
MSM: MSMEG_5224(ispH)
MUL: MUL_0168(ispH)
MVA: Mvan_4631
MGI: Mflv_2079(ispH)
MAB: MAB_1257(ispH)
MMC: Mmcs_4105(ispH)
MKM: Mkms_4181(ispH)
MJL: Mjls_4336(ispH)
MMI: MMAR_0277(lytB2) MMAR_4355(ispH)
CGL: NCgl0982(ispH)
CGB: cg1164(ispH)
CGT: cgR_1109(ispH)
CEF: CE1079(ispH)
CDI: DIP0943(ispH)
CJK: jk1449(ispH)
CUR: cur_0618(ispH)
CAR: cauri_0943(lytB)
NFA: nfa47950(ispH)
RHA: RHA1_ro05870(ispH)
RER: RER_42340(ispH)
ROP: ROP_59320(ispH)
GBR: Gbro_1680
SCO: SCO5058(ispH)
SMA: SAV_3210(ispH)
SGR: SGR_2472(ispH)
TWH: TWT642(ispH)
TWS: TW664(ispH)
LXX: Lxx16760(ispH)
CMI: CMM_2228(ispH)
CMS: CMS_2415(ispH)
ART: Arth_2833(ispH)
ACH: Achl_2548
RSA: RSal33209_1156(ispH)
KRH: KRH_07120(ispH)
MLU: Mlut_16300
BCV: Bcav_1102
BFA: Bfae_22960
JDE: Jden_0747
KSE: Ksed_20400
XCE: Xcel_0941
PAC: PPA0572(ispH)
NCA: Noca_1075
TFU: Tfu_0471(ispH)
TCU: Tcur_1091
SRO: Sros_3713 Sros_8480
FRA: Francci3_0824 Francci3_3881(ispH)
FRE: Franean1_0845(ispH) Franean1_5712
FAL: FRAAL1433(ispH) FRAAL6150(ispH)
ACE: Acel_1858
NML: Namu_4387
KRA: Krad_1123
SEN: SACE_0939(ispH) SACE_4326(ispH)
SVI: Svir_31480
AMI: Amir_0729 Amir_5019
STP: Strop_0879(ispH)
SAQ: Sare_0824(ispH)
CAI: Caci_8273
BLO: BL1361(ispH)
BLJ: BLD_0227(ispH)
BLN: Blon_0898(ispH)
BAD: BAD_1081(ispH)
BLA: BLA_0742(ispH)
BLC: Balac_1164
BLT: Balat_1164
RXY: Rxyl_2212
AFO: Afer_1349
CCU: Ccur_06870
SHI: Shel_09680
APV: Apar_0726
ELE: Elen_1335
CTR: CT859(ispH)
CTA: CTA_0937(ispH)
CTB: CTL0234(ispH)
CTL: CTLon_0234(ispH)
CTJ: JALI_8701(ispH)
CMU: TC0249(ispH)
CPN: CPn1017(ispH)
CPA: CP0836(ispH)
CPJ: CPj1017(ispH)
CPT: CpB1055(ispH)
CCA: CCA00744(ispH)
CAB: CAB711(ispH)
CFE: CF0272(ispH)
PCU: pc1078(ispH)
TPA: TP0547
TPP: TPASS_0547(lytB)
TDE: TDE1096(ispH)
LIL: LA2420(lytB)
LIC: LIC11529(lytB)
LBJ: LBJ_1807(lytB)
LBL: LBL_1476(lytB)
LBI: LEPBI_I1588(ispH)
LBF: LBF_1537(lytB)
BHY: BHWA1_01221
ABA: Acid345_1739
ACA: ACP_3328(ispH)
SUS: Acid_1259
BTH: BT_2061(ispH)
BFR: BF3748(ispH)
BFS: BF3536(ispH)
BVU: BVU_1936
PGI: PG0604(ispH)
PGN: PGN_0647(ispH)
PDI: BDI_3740(ispH)
APS: CFPG_127(ispH)
SRU: SRU_1880(ispH)
RMR: Rmar_0711
CHU: CHU_0087(ispH)
DFE: Dfer_3543
CPI: Cpin_6621
PHE: Phep_3618
FSU: Fisuc_1940
FNU: FN1781
STR: Sterm_4093
OTE: Oter_3652
MIN: Minf_2119(lytB)
AMU: Amuc_1646
GAU: GAU_2758(ispH)
RBA: RB9288(lytB)
EMI: Emin_0409
RSD: TGRD_661
TAI: Taci_1028
SYN: slr0348
SYW: SYNW0252(lytB)
SYC: syc1431_d(lytB)
SYF: Synpcc7942_0073
SYD: Syncc9605_0246
SYE: Syncc9902_0275
SYG: sync_0292(ispH)
SYR: SynRCC307_2319(lytB)
SYX: SynWH7803_0296(lytB)
SYP: SYNPCC7002_A0517(ispH)
CYA: CYA_1148(ispH)
CYB: CYB_2643(ispH)
TEL: tlr1041
MAR: MAE_16190
CYT: cce_1108
CYP: PCC8801_2610
CYC: PCC7424_4926
CYN: Cyan7425_2354
CYH: Cyan8802_3496
GVI: glr3299
ANA: all0985
NPU: Npun_R3286
AVA: Ava_2949
PMA: Pro0296(lytB)
PMM: PMM0264(lytB)
PMT: PMT1854(lytB)
PMN: PMN2A_1630
PMI: PMT9312_0266
PMB: A9601_02861(lytB)
PMC: P9515_02971(lytB)
PMF: P9303_24821(lytB)
PMG: P9301_02871(lytB)
PMH: P9215_02881(lytB)
PMJ: P9211_02911(lytB)
PME: NATL1_03421(lytB)
TER: Tery_4479
AMR: AM1_4950(ispH)
CTE: CT0283(ispH)
CPC: Cpar_1751(ispH)
CCH: Cag_0579(ispH)
CPH: Cpha266_0414(ispH)
CPB: Cphamn1_0456(ispH)
CLI: Clim_0345(ispH)
PVI: Cvib_1518(ispH)
PLT: Plut_1736(ispH)
PPH: Ppha_0448(ispH)
PAA: Paes_0419(ispH)
CTS: Ctha_0114(ispH)
DET: DET1344(ispH)
DEH: cbdb_A1294(ispH)
DEB: DehaBAV1_1155
DEV: DhcVS_1126(ispH)
TRO: trd_1164(ispH) trd_1662(ispH)
STI: Sthe_0330
DRA: DR_2164
DGE: Dgeo_1010
DDR: Deide_10440
TTH: TTC1983(lytB)
TTJ: TTHA0015
AAE: aq_1739(lytB)
HYA: HY04AAS1_1048
SUL: SYO3AOP1_1148
SAF: SULAZ_0297(ispH)
PMX: PERMA_0082(ispH)
TMA: TM1444
TPT: Tpet_1350
TLE: Tlet_1650
TRQ: TRQ2_1336
TNA: CTN_1049
TNP: Tnap_1368
PMO: Pmob_1619
KOL: Kole_0213
DTH: DICTH_1030(ispH)
DTU: Dtur_1158
TYE: THEYE_A1769(ispH)
TTR: Tter_0639
Taxonomy
Structures PDB: 3DNF  3F7T  3KE8  3KE9  3KEF  3KEL  3KEM  
Reference
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  Title

  Journal
  Organism
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Rohdich F, Hecht S, Gartner K, Adam P, Krieger C, Amslinger S,
Arigoni D, Bacher A, Eisenreich W.
Studies on the nonmevalonate terpene biosynthetic pathway: metabolic
role of IspH (LytB) protein.
Proc. Natl. Acad. Sci. U. S. A. 99 (2002) 1158-63.
Escherichia coli [GN:eco]
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Hintz M, Reichenberg A, Altincicek B, Bahr U, Gschwind RM, Kollas
AK, Beck E, Wiesner J, Eberl M, Jomaa H.
Identification of (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate as
a major activator for human gammadelta T cells in Escherichia coli.
FEBS. Lett. 509 (2001) 317-22.
Escherichia coli [GN:eco]
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Charon, L., Pale-Grosdemange, C. and Rohmer, M.
On the reduction steps in the mevalonate independent
2-C-methyl-D-erythritol 4-phosphate (MEP) pathway for isoprenoid
biosynthesis in the bacterium Zymomonas mobilis.
Tetrahedron Lett. 40 (1999) 7231-7234.
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Charon, L., Pale-Grosdemange, C. and Rohmer, M.
On the reduction steps in the mevalonate independent
2-C-methyl-D-erythritol 4-phosphate (MEP) pathway for isoprenoid
biosynthesis in the bacterium Zymomonas mobilis.
Tetrahedron Lett. 40 (1999) 7231-7234.
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Rohrich RC, Englert N, Troschke K, Reichenberg A, Hintz M, Seeber F,
Balconi E, Aliverti A, Zanetti G, Kohler U, Pfeiffer M, Beck E,
Jomaa H, Wiesner J
Reconstitution of an apicoplast-localised electron transfer pathway
involved in the isoprenoid biosynthesis of Plasmodium falciparum.
FEBS. Lett. 579 (2005) 6433-8.
Plasmodium falciparum
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Rohrich RC, Englert N, Troschke K, Reichenberg A, Hintz M, Seeber F,
Balconi E, Aliverti A, Zanetti G, Kohler U, Pfeiffer M, Beck E,
Jomaa H, Wiesner J
Reconstitution of an apicoplast-localised electron transfer pathway
involved in the isoprenoid biosynthesis of Plasmodium falciparum.
FEBS. Lett. 579 (2005) 6433-8.
Plasmodium falciparum
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Wolff M, Seemann M, Tse Sum Bui B, Frapart Y, Tritsch D, Garcia
Estrabot A, Rodriguez-Concepcion M, Boronat A, Marquet A, Rohmer M
Isoprenoid biosynthesis via the methylerythritol phosphate pathway:
the (E)-4-hydroxy-3-methylbut-2-enyl diphosphate reductase
(LytB/IspH) from Escherichia coli is a [4Fe-4S] protein.
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Escherichia coli [GN:eco]
Reference
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  Journal
  Organism
 8  [PMID:12706830]
Wolff M, Seemann M, Tse Sum Bui B, Frapart Y, Tritsch D, Garcia
Estrabot A, Rodriguez-Concepcion M, Boronat A, Marquet A, Rohmer M
Isoprenoid biosynthesis via the methylerythritol phosphate pathway:
the (E)-4-hydroxy-3-methylbut-2-enyl diphosphate reductase
(LytB/IspH) from Escherichia coli is a [4Fe-4S] protein.
FEBS. Lett. 541 (2003) 115-20.
Escherichia coli [GN:eco]
Reference
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  Organism
 9  [PMID:15469281]
Grawert T, Kaiser J, Zepeck F, Laupitz R, Hecht S, Amslinger S,
Schramek N, Schleicher E, Weber S, Haslbeck M, Buchner J, Rieder C,
Arigoni D, Bacher A, Eisenreich W, Rohdich F
IspH protein of Escherichia coli: studies on iron-sulfur cluster
implementation and catalysis.
J. Am. Chem. Soc. 126 (2004) 12847-55.
Escherichia coli [GN:eco]
Reference
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  Organism
 10 [PMID:15469281]
Grawert T, Kaiser J, Zepeck F, Laupitz R, Hecht S, Amslinger S,
Schramek N, Schleicher E, Weber S, Haslbeck M, Buchner J, Rieder C,
Arigoni D, Bacher A, Eisenreich W, Rohdich F
IspH protein of Escherichia coli: studies on iron-sulfur cluster
implementation and catalysis.
J. Am. Chem. Soc. 126 (2004) 12847-55.
Escherichia coli [GN:eco]
Other DBs ExplorEnz - The Enzyme Database: 1.17.1.2
IUBMB Enzyme Nomenclature: 1.17.1.2
ExPASy - ENZYME nomenclature database: 1.17.1.2
BRENDA, the Enzyme Database: 1.17.1.2
CAS: 512789-14-9
DBGET integrated database retrieval system