KEGG   ENZYME: 1.17.1.3Help
Entry
EC 1.17.1.3                 Enzyme                                 

Name
leucoanthocyanidin reductase;
leucocyanidin reductase
Class
Oxidoreductases;
Acting on CH or CH2 groups;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
(2R,3S)-catechin:NADP+ 4-oxidoreductase
Reaction(IUBMB)
(2R,3S)-catechin + NADP+ + H2O = 2,3-trans-3,4-cis-leucocyanidin + NADPH + H+ [RN:R06532]
Reaction(KEGG)
R06532;
(other) R06533 R06615
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Substrate
(2R,3S)-catechin [CPD:C06562];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Product
2,3-trans-3,4-cis-leucocyanidin [CPD:C05906];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme catalyses the synthesis of catechin, catechin-4beta-ol (leucocyanidin) and the related flavan-3-ols afzelechin and gallocatechin, which are initiating monomers in the synthesis of plant polymeric proanthocyanidins or condensed tannins. While 2,3-trans-3,4-cis-leucocyanidin is the preferred flavan-3,4-diol substrate, 2,3-trans-3,4-cis-leucodelphinidin and 2,3-trans-3,4-cis-leucopelargonidin can also act as substrates, but more slowly. NADH can replace NADPH but is oxidized more slowly.
History
EC 1.17.1.3 created 2003
Pathway
Flavonoid biosynthesis
Biosynthesis of secondary metabolites
Orthology
K13081  
leucoanthocyanidin reductase
Genes
GMX: 
MTR: 
CAM: 
FVE: 
RCU: 
POP: 
POPTR_0008s11540g(POPTRDRAFT_656768) POPTR_0010s13990g(POPTRDRAFT_566672) POPTR_0015s03360g(POPTRDRAFT_835080)
VVI: 
100232982(LAR1) 100233112(LAR2)
OSA: 
DOSA: 
Os03t0259400-00(Os03g0259400)
BDI: 
Taxonomy
Reference
1  [PMID:8470799]
  Authors
Tanner GJ, Kristiansen KN.
  Title
Synthesis of 3,4-cis-[3H]leucocyanidin and enzymatic reduction to catechin.
  Journal
Anal. Biochem. 209 (1993) 274-7.
  Organism
Onobrychis viciifolia
Reference
2  [PMID:12788945]
  Authors
Tanner GJ, Francki KT, Abrahams S, Watson JM, Larkin PJ, Ashton AR.
  Title
Proanthocyanidin biosynthesis in plants. Purification of legume leucoanthocyanidin reductase and molecular cloning of its cDNA.
  Journal
J. Biol. Chem. 278 (2003) 31647-56.
  Organism
Desmodium uncinatum
  Sequence
[up:Q84V83]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
776323-46-7

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