| Entry |
|
|---|
| Name |
uracil/thymine dehydrogenase;
uracil oxidase;
uracil-thymine oxidase;
uracil dehydrogenase |
|---|
| Class |
Oxidoreductases;
Acting on CH or CH2 groups;
With other acceptors
 |
|---|
| Sysname |
uracil:acceptor oxidoreductase |
|---|
| Reaction(IUBMB) |
(1) uracil + H2O + acceptor = barbiturate + reduced acceptor
[RN:R00976];
(2) thymine + H2O + acceptor = 5-methylbarbiturate + reduced
acceptor [RN:R01413] |
|---|
| Reaction(KEGG) |
R00976 R01413
 |
|---|
| Substrate |
uracil [CPD:C00106];
H2O [CPD:C00001];
acceptor [CPD:C00028];
thymine [CPD:C00178] |
|---|
| Product |
barbiturate [CPD:C00813];
reduced acceptor [CPD:C00030];
5-methylbarbiturate [CPD:C05281] |
|---|
| Comment |
Forms part of the oxidative pyrimidine-degrading pathway in some
microorganisms, along with EC 3.5.2.1 (barbiturase) and EC 3.5.1.95
(N-malonylurea hydrolase). Mammals, plants and other microorganisms
utilize the reductive pathway, comprising EC 1.3.1.1 [dihydrouracil
dehydrogenase (NAD+)] or EC 1.3.1.2 [dihydropyrimidine dehydrogenase
(NADP+)], EC 3.5.2.2 (dihydropyrimidinase) and EC 3.5.1.6
(beta-ureidopropionase), with the ultimate degradation products
being an L-amino acid, NH3 and CO2 [5]. |
|---|
| Pathway |
PATH: ec00240 Pyrimidine metabolism |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:12981104]
HAYAISHI O, KORNBERG A.
Metabolism of cytosine, thymine, uracil, and barbituric acid by
bacterial enzymes.
J. Biol. Chem. 197 (1952) 717-32.
Corynebacterium sp., Mycobacterium sp. |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:14927671]
WANG TP, LAMPEN JO.
Metabolism of pyrimidines by a soil bacterium.
J. Biol. Chem. 194 (1952) 775-83.
Bacterium sp. |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:14927672]
WANG TP, LAMPEN JO.
Uracil oxidase and the isolation of barbituric acid from uracil
oxidation.
J. Biol. Chem. 194 (1952) 785-91.
Corynebacterium sp., Mycobacterium sp. |
|---|
Reference
Authors
Title
Journal
Organism
|
4 [PMID:14955523]
LARA FJ.
On the decomposition of pyrimidines by bacteria. II. Studies with
cell-free enzyme preparations.
J. Bacteriol. 64 (1952) 279-85.
Nocardia corallina |
|---|
Reference
Authors
Title
Journal
Organism
|
5 [PMID:11485332]
Soong CL, Ogawa J, Shimizu S.
Novel amidohydrolytic reactions in oxidative pyrimidine metabolism:
analysis of the barbiturase reaction and discovery of a novel
enzyme, ureidomalonase.
Biochem. Biophys. Res. Commun. 286 (2001) 222-6.
Corynebacterium sp., Mycobacterium sp. |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.17.99.4
IUBMB Enzyme Nomenclature: 1.17.99.4
ExPASy - ENZYME nomenclature database: 1.17.99.4
BRENDA, the Enzyme Database: 1.17.99.4
CAS: 9029-00-9 |
|---|
