| Entry |
|
|---|
| Name |
rubredoxin---NAD+ reductase;
rubredoxin reductase;
rubredoxin-nicotinamide adenine dinucleotide reductase;
dihydronicotinamide adenine dinucleotide-rubredoxin reductase;
reduced nicotinamide adenine dinucleotide-rubredoxin reductase;
NADH-rubredoxin reductase;
rubredoxin-NAD reductase;
NADH: rubredoxin oxidoreductase;
DPNH-rubredoxin reductase;
NADH-rubredoxin oxidoreductase |
|---|
| Class |
Oxidoreductases;
Acting on iron-sulfur proteins as donors;
With NAD+ or NADP+ as acceptor
 |
|---|
| Sysname |
rubredoxin:NAD+ oxidoreductase |
|---|
| Reaction(IUBMB) |
2 reduced rubredoxin + NAD+ + H+ = 2 oxidized rubredoxin + NADH
[RN:R02000] |
|---|
| Reaction(KEGG) |
R02000
 |
|---|
| Substrate |
reduced rubredoxin [CPD:C00340];
NAD+ [CPD:C00003];
H+ [CPD:C00080] |
|---|
| Product |
oxidized rubredoxin [CPD:C00435];
NADH [CPD:C00004] |
|---|
| Cofactor |
FAD [CPD:C00016];
Iron [CPD:C00023] |
|---|
| Comment |
Requires FAD. The enzyme from Clostridium acetobutylicum reduces
rubredoxin, ferricyanide and dichlorophenolindophenol, but not
ferredoxin or flavodoxin. The reaction does not occur when NADPH is
substituted for NADH. Contains iron at the redox centre. |
|---|
| Pathway |
PATH: ec00071 Fatty acid metabolism |
|---|
| Orthology |
KO: K05297 rubredoxin-NAD+ reductase |
|---|
| Genes |
PAE: PA5349
PAU: PA14_70620(rubB)
PPU: PP_5314(rubB) PP_5371
PPF: Pput_5223
PST: PSPTO_5473(rubB)
PSB: Psyr_5028
PSP: PSPPH_5110(rubB)
PFL: PFL_6103(rubB)
PFO: Pfl01_5601
PEN: PSEEN5459(rubB)
PSA: PST_0438(rubB)
ACI: ACIAD1065(rubB)
ACB: A1S_0994
ABM: ABSDF2404(rubB)
ABY: ABAYE1067 ABAYE2799(rubB)
SDN: Sden_3466
MAQ: Maqu_3591
CBU: CBU_0276
TCX: Tcr_0037
HCH: HCH_00777
PNU: Pnuc_1378
RFR: Rfer_0092
POL: Bpro_4857
MPT: Mpe_A3669
HAR: HEAR0644(norW)
NEU: NE1420
NMU: Nmul_A0171
EBA: ebA6036
TBD: Tbd_2315
MFA: Mfla_2173
MEX: Mext_1149
MDI: METDI1722
MPO: Mpop_4666
MCH: Mchl_1308
GOX: GOX1746
MAG: amb3427
MGM: Mmc1_3270
EEL: EUBELI_20024
 |
|---|
| Structures |
PDB: 1BFY |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:4294330]
Peterson JA, Kusunose M, Kusunose E, Coon MJ.
Enzymatic omega-oxidation. II. Function of rubredoxin as the
electron carrier in omega-hydroxylation.
J. Biol. Chem. 242 (1967) 4334-40.
Pseudomonas oleovorans |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:4335861]
.
Enzymatic -oxidation. VI. Isolation of homogeneous reduced
diphosphopyridine nucleotide-rubredoxin reductase.
J. Biol. Chem. 247 (1972) 2109-16.
Pseudomonas oleovorans |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:4403503]
Ueda T, Coon MJ.
Enzymatic oxidation. VII. Reduced diphosphopyridine
nucleotide-rubredoxin reductase: properties and function as an
electron carrier in hydroxylation.
J. Biol. Chem. 247 (1972) 5010-6.
Pseudomonas oleovorans |
|---|
Reference
Authors
Title
Journal
Organism
|
4 [PMID:526302]
Petitdemange H, Marczak R, Blusson H, Gay R.
Isolation and properties of reduced nicotinamide adenine
dinucleotiderubredoxin oxidoreductase of Clostridium acetobutylicum.
Biochem. Biophys. Res. Commun. 91 (1979) 1258-65.
Clostridium acetobutylicum [GN:cac] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.18.1.1
IUBMB Enzyme Nomenclature: 1.18.1.1
ExPASy - ENZYME nomenclature database: 1.18.1.1
BRENDA, the Enzyme Database: 1.18.1.1
CAS: 9032-27-3 |
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