KEGG   ENZYME: 1.18.1.6Help
Entry
EC 1.18.1.6                 Enzyme                                 

Name
adrenodoxin-NADP+ reductase;
adrenodoxin reductase;
nicotinamide adenine dinucleotide phosphate-adrenodoxin reductase;
AdR;
NADPH:adrenal ferredoxin oxidoreductase;
NADPH-adrenodoxin reductase
Class
Oxidoreductases;
Acting on iron-sulfur proteins as donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
adrenodoxin:NADP+ oxidoreductase
Reaction(IUBMB)
2 reduced adrenodoxin + NADP+ = 2 oxidized adrenodoxin + NADPH + H+ [RN:R10159]
Reaction(KEGG)
Substrate
reduced adrenodoxin [CPD:C00662];
NADP+ [CPD:C00006]
Product
oxidized adrenodoxin [CPD:C00667];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
A flavoprotein (FAD). The enzyme is the first component in the mitochondrial cytochrome P-450 electron transfer systems, and is involved in the biosynthesis of all steroid hormones.
History
EC 1.18.1.6 created 1965 as EC 1.6.99.4, transferred 1972 as EC 1.6.7.1, transferred 1978 to EC 1.18.1.2, part transferred 2012 to 1.18.1.6
Reference
1
  Authors
Omura, T., Sanders, E., Estabrook, R.W., Cooper, D.Y. and Rosenthal, O.
  Title
Isolation from adrenal cortex of a nonheme iron protein and a flavoprotein functional as a reduced triphosphopyridine nucleotide-cytochrome P-450 reductase.
  Journal
Arch. Biochem. Biophys. 117 (1966) 660-673.
Reference
2  [PMID:4144106]
  Authors
Chu JW, Kimura T
  Title
Studies on adrenal steroid hydroxylases. Molecular and catalytic properties of adrenodoxin reductase (a flavoprotein).
  Journal
J. Biol. Chem. 248 (1973) 2089-94.
Reference
3  [PMID:235468]
  Authors
Sugiyama T, Yamano T
  Title
Purification and crystallization of NADPH-adrenodoxin reductase from bovine adrenocortical mitochondria.
  Journal
FEBS. Lett. 52 (1975) 145-8.
Reference
4  [PMID:6766943]
  Authors
Hanukoglu I, Jefcoate CR.
  Title
Mitochondrial cytochrome P-450sec. Mechanism of electron transport by adrenodoxin.
  Journal
J. Biol. Chem. 255 (1980) 3057-61.
Reference
5  [PMID:3011431]
  Authors
Hanukoglu I, Hanukoglu Z
  Title
Stoichiometry of mitochondrial cytochromes P-450, adrenodoxin and adrenodoxin reductase in adrenal cortex and corpus luteum. Implications for membrane organization and gene regulation.
  Journal
Eur. J. Biochem. 157 (1986) 27-31.
Reference
6  [PMID:2924777]
  Authors
Hanukoglu I, Gutfinger T
  Title
cDNA sequence of adrenodoxin reductase. Identification of NADP-binding sites in oxidoreductases.
  Journal
Eur. J. Biochem. 180 (1989) 479-84.
  Organism
Bos taurus
  Sequence
[bta:282604]
Reference
7  [PMID:10369776]
  Authors
Ziegler GA, Vonrhein C, Hanukoglu I, Schulz GE
  Title
The structure of adrenodoxin reductase of mitochondrial P450 systems: electron transfer for steroid biosynthesis.
  Journal
J. Mol. Biol. 289 (1999) 981-90.
  Organism
Bos taurus
  Sequence
[bta:282604]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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