| Entry |
|
|---|
| Name |
acetaldehyde dehydrogenase (acetylating);
aldehyde dehydrogenase (acylating);
ADA;
acylating acetaldehyde dehyrogenase;
DmpF |
|---|
| Class |
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
 |
|---|
| Sysname |
acetaldehyde:NAD+ oxidoreductase (CoA-acetylating) |
|---|
| Reaction(IUBMB) |
acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH + H+ [RN:R00228] |
|---|
| Reaction(KEGG) |
R00228;
(other) R01172
 |
|---|
| Substrate |
acetaldehyde [CPD:C00084];
CoA [CPD:C00010];
NAD+ [CPD:C00003] |
|---|
| Product |
acetyl-CoA [CPD:C00024];
NADH [CPD:C00004];
H+ [CPD:C00080] |
|---|
| Comment |
Also acts, more slowly, on glycolaldehyde, propanal and butanal. In
Pseudomonas species, this enzyme forms part of a bifunctional enzyme
with EC 4.1.3.39, 4-hydroxy-2-oxovalerate aldolase. It is the final
enzyme in the meta-cleavage pathway for the degradation of phenols,
cresols and catechol, converting the acetaldehyde produced by EC
4.1.3.39 into acetyl-CoA [3]. NADP+ can replace NAD+ but the rate of
reaction is much slower [3]. |
|---|
| Pathway |
PATH: ec00620 Pyruvate metabolism
PATH: ec00650 Butanoate metabolism
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K00132 acetaldehyde dehydrogenase (acetylating)
KO: K04072 acetaldehyde dehydrogenase
KO: K04073 acetaldehyde dehydrogenase |
|---|
| Genes |
CPV: cgd8_1720
CHO: Chro.80199
ECO: b0351(mhpF) b1241(adhE)
ECJ: JW0342(mhpF) JW1228(adhE)
ECD: ECDH10B_1302(adhE)
EBW: BWG_0240(mhpF) BWG_1066(adhE)
ECE: Z0450(mhpF) Z2016(adhE)
ECS: ECs0406 ECs1741
ECF: ECH74115_0426(mhpF) ECH74115_1725(adhE)
ETW: ECSP_0415(mhpF) ECSP_1631(adhE)
ECG: E2348C_1367(adhE)
ECC: c1705(adhE)
ECI: UTI89_C1438(adhE)
ECP: ECP_1287
ECV: APECO1_355(adhE)
ECW: EcE24377A_0375(mhpF) EcE24377A_1389(adhE)
ECX: EcHS_A0415(mhpF) EcHS_A1350(adhE)
ECM: EcSMS35_0382(mhpF) EcSMS35_1901(adhE)
ECY: ECSE_0376 ECSE_1289
ECL: EcolC_2387 EcolC_3274
ECK: EC55989_0358(mhpF) EC55989_1337(adhE)
ECQ: ECED1_0379(mhpF) ECED1_1392(adhE)
ECR: ECIAI1_0352(mhpF) ECIAI1_1259(adhE)
ECT: ECIAI39_0327(mhpF) ECIAI39_1575(adhE)
ECZ: ECS88_1308(adhE)
EUM: ECUMN_0394(mhpF) ECUMN_1538(adhE)
ELF: LF82_0035(adhE)
EBL: B21_00309(mhpF) B21_01225(adhE)
EBD: ECBD_2383 ECBD_3306
EBR: ECB_00305(mhpF) ECB_01215(adhE)
EOH: ECO103_0333(mhpF) ECO103_1341(adhE)
EOI: ECO111_0387(mhpF) ECO111_1568(adhE)
EOJ: ECO26_0387(mhpF) ECO26_1752(adhE)
EFE: EFER_1714(adhE)
STY: STY1302(adh)
STT: t1660(adh)
SPT: SPA1129(adh)
SEK: SSPA1048
SPQ: SPAB_01493 SPAB_02687
SEI: SPC_1980(adh)
SEC: SC1744(adhE)
SEH: SeHA_C1939(adhE)
SEE: SNSL254_A1876(adhE)
SEW: SeSA_A1882(adhE)
SEA: SeAg_B1396(adhE)
SED: SeD_A1579(adhE)
SEG: SG1367(adhE)
SET: SEN1287(adhE)
SES: SARI_01204
STM: STM1749(adhE)
YPE: YPO2180(adhE)
YPK: y2023(adhE)
YPM: YP_1976(adhE)
YPA: YPA_1537
YPN: YPN_1646
YPG: YpAngola_A2165(adhE)
YPP: YPDSF_0956
YPS: YPTB2103(adhE)
YPI: YpsIP31758_1963(adhE)
YPY: YPK_2072
YPB: YPTS_2171
YEN: YE2238(adhE)
SFL: SF1240(adhE)
SFX: S1326(adhE)
SFV: SFV_1253(adhE)
SSN: SSON_0330(mhpF) SSON_1939(adhE)
SBO: SBO_1828(adhE)
SBC: SbBS512_E1406(adhE)
SDY: SDY_1295(adhE)
ECA: ECA1428(nahO) ECA2326(adhE)
PCT: PC1_1983
PWA: Pecwa_2284
ETA: ETA_15810(adhE)
PLU: plu2496(adhE)
PAY: PAU_02030(adhE)
SGL: SG1372
ENT: Ent638_2304
ESA: ESA_01539
CTU: Ctu_23840(adhE)
KPN: KPN_02118(mhpF) KPN_02199(adhE)
KPE: KPK_2109(adhE) KPK_2205(mhpF)
KPU: KP1_3213(mhpF) KP1_3311(adhE)
CKO: CKO_01318
SPE: Spro_2704 Spro_3026
PMR: PMI1486(adhE)
EIC: NT01EI_1665
ETR: ETAE_1508(adhE)
DDA: Dd703_1955
DDC: Dd586_2144
DZE: Dd1591_2197
PMU: PM1453(adh2)
MSU: MS2190(eutG)
APL: APL_1011(adh2)
APJ: APJL_1029(adh2)
APA: APP7_1068(adhE)
ASU: Asuc_0591
AAP: NT05HA_1312
AAT: D11S_1811
VCH: VC2033
VCO: VC0395_A1619(adhE)
VCM: VCM66_1957(adhE)
VCJ: VCD_002334
VVU: VV1_3111
VVY: VV1175
VPA: VP2121
VHA: VIBHAR_03018
VSP: VS_0958
VEX: VEA_002931
VFI: VF_0918(adhE)
VFM: VFMJ11_0957
VSA: VSAL_I1855(adhE)
PPR: PBPRA1103
PPF: Pput_2874 Pput_2889
PPW: PputW619_1983 PputW619_2008
CJA: CJA_1528(nahO)
AVN: Avin_08700(xylQ) Avin_30580(lapF) Avin_42130
SON: SO_2136(adhE)
SDN: Sden_2000
SFR: Sfri_1898
SAZ: Sama_1693
SBL: Sbal_1922
SBM: Shew185_1948
SBN: Sbal195_1955
SBP: Sbal223_2371
SLO: Shew_1910
SPC: Sputcn32_1811
SSE: Ssed_2349
SPL: Spea_2044 Spea_2117
SHE: Shewmr4_1683
SHM: Shewmr7_1758
SHN: Shewana3_1788
SHW: Sputw3181_2214
SHL: Shal_2089 Shal_2250
SWD: Swoo_1391 Swoo_2241
SWP: swp_2623
PHA: PSHAa2142(mhpF)
TTU: TERTU_0505 TERTU_1282
AEH: Mlg_2461
MMW: Mmwyl1_3802
AHA: AHA_2616
ASA: ASA_1695(adhE)
TAU: Tola_2176 Tola_2293
CVI: CV_1137(adhE)
RSO: RS01665(RSp0894)
RPI: Rpic_4618
RPF: Rpic12D_3542
REU: Reut_B5824
REH: H16_A1806 H16_B0551(mhpF) H16_B0596
RME: Rmet_1320 Rmet_5208
CTI: RALTA_B0400(mhpF)
BPS: BPSS1808(mhpF)
BPM: BURPS1710b_A0891(mhpF)
BPL: BURPS1106A_A2455
BPD: BURPS668_A2591
BTE: BTH_II0569(mhpF)
BVI: Bcep1808_5385 Bcep1808_7604
BUR: Bcep18194_B1187 Bcep18194_B1458 Bcep18194_B2960 Bcep18194_C7645
BCJ: BCAM1614(mhpF) BCAM2122
BXE: Bxe_A1151(amnH) Bxe_A3547 Bxe_B2326 Bxe_C1188(bphJ)
BPH: Bphy_3511 Bphy_4538
BPY: Bphyt_1467
BGL: bglu_2g02760
BAV: BAV0599(bphG)
RFR: Rfer_0455
POL: Bpro_5135
PNA: Pnap_4143
AJS: Ajs_0223
VEI: Veis_2782
CTT: CtCNB1_3148
MPT: Mpe_A2267 Mpe_A3322
LCH: Lcho_3341
AZO: azo1856(lapF) azo1973(mhpF) azo2432(nahO)
DAR: Daro_0906 Daro_1355 Daro_3239 Daro_3783 Daro_3807
TMZ: Tmz1t_2078
GUR: Gura_3537
GLO: Glov_0177
PCA: Pcar_2758 Pcar_2851
PPD: Ppro_0756
DVM: DvMF_2322
DDE: Dde_3283
ARA: Arad_7256
RPC: RPC_4481
RPE: RPE_3692
XAU: Xaut_0937
MSL: Msil_1478
NAR: Saro_3688
SWI: Swit_4924
BAN: BA4599
BAR: GBAA4599
BAA: BA_5039
BAT: BAS4267
BAH: BAMEG_4636
BAI: BAA_4619
BCE: BC4365
BCA: BCE_2156 BCE_4453
BCZ: BCZK4115
BCR: BCAH187_A4504
BCB: BCB4264_A4490
BCU: BCAH820_4451
BCG: BCG9842_B0746
BCQ: BCQ_4155
BCX: BCA_2154 BCA_4483
BTK: BT9727_4104
BTL: BALH_1843 BALH_3956
BWE: BcerKBAB4_4218
BLI: BL00199
BLD: BLi04290
GTN: GTNG_3152(nbaJ)
GYM: GYMC10_2063
GYC: GYMC61_2297
AFL: Aflv_2814
SAU: SA0143(adhE)
SAV: SAV0148(adhE)
SAW: SAHV_0147(adhE)
SAM: MW0123(adhE)
SAR: SAR0150(adhE)
SAS: SAS0123
SAC: SACOL0135
SAB: SAB0089
SAA: SAUSA300_0151(adhE)
SAX: USA300HOU_0162
SAO: SAOUHSC_00113
SAJ: SaurJH9_0134
SAH: SaurJH1_0139
SAE: NWMN_0094(adhE)
SAD: SAAV_0116
SEP: SE0506
SER: SERP0389
LMO: lmo1634
LMF: LMOf2365_1656(adhE)
LMH: LMHCC_0928
LMC: Lm4b_01645
LIN: lin1675
LWE: lwe1650
ESI: Exig_1232
EAT: EAT1b_0155
BBE: BBR47_29770
AAC: Aaci_1620
LLA: L13145(adhE)
LLK: LLKF_2398(adhE)
LLC: LACR_2457
LLM: llmg_2432(adhE)
SPZ: M5005_Spy_0039(adh2)
SPM: spyM18_0043(adhE)
SPG: SpyM3_0036(adh2)
SPS: SPs0037
SPH: MGAS10270_Spy0042
SPI: MGAS10750_Spy0041
SPJ: MGAS2096_Spy0041
SPK: MGAS9429_Spy0040(adh2)
SPF: SpyM50039(adhE)
SPA: M6_Spy0088
SPB: M28_Spy0039
SOZ: Spy49_0038(adhE)
SPN: SP_2026
SPD: SPD_1834
SPR: spr1837(adhE)
SPW: SPCG_1991(adhE)
SPX: SPG_1938
SNE: SPN23F_20460(adhE)
SPV: SPH_2179
SNM: SP70585_2111
SJJ: SPJ_2031
SPP: SPP_2062
SNT: SPT_2021
SAG: SAG0053(adhE)
SAN: gbs0053
SAK: SAK_0086
SMU: SMU.148(adhE)
STC: str1879 str1881 str1882 str1884
STL: stu1879 stu1880 stu1881 stu1882 stu1883 stu1884
SSA: SSA_0068(adhE)
SSU: SSU05_0280
SSV: SSU98_0275
SSB: SSUBM407_0252(adhE)
SSI: SSU0261(adhE)
SSS: SSUSC84_0250(adhE)
SGO: SGO_0113(acdH)
SEQ: SZO_00440
SEZ: Sez_0043(adh2)
SEU: SEQ_0044
SUB: SUB0063(adhE)
SDS: SDEG_0061(adh2)
LPL: lp_3662(adhE)
LPJ: JDM1_2930(adhE)
LJO: LJ1766
LJF: FI9785_1548(adhE)
LAC: LBA0461(adhE)
LSA: LSA0379(adhE)
LSL: LSL_1901
LDB: Ldb1707
LBU: LBUL_1581
LBR: LVIS_0119
LCA: LSEI_0775
LCB: LCABL_08380(adhE)
LGA: LGAS_1561
LRE: Lreu_0321
LRF: LAR_0310
LFE: LAF_0277
LRH: LGG_00757(adhE)
LRL: LC705_00751(adhE)
EFA: EF0900(adhE)
OOE: OEOE_1248
LME: LEUM_0146
LCI: LCK_00119(adhE)
CAC: CA_P0035(adhE) CA_P0162(adhe1)
CPE: CPE2531(adhE)
CPF: CPF_2855(adhE)
CPR: CPR_2540
CTC: CTC01366 CTC01441
CTH: Cthe_0423
CDF: CD0334(adhE) CD2966(adhE)
CDC: CD196_0353(adhE) CD196_2753(adhE)
CDL: CDR20291_0339(adhE) CDR20291_2800(adhE)
CBO: CBO0345(aad) CBO2108(eutE)
CBA: CLB_0388(adhE) CLB_2045(eutE)
CBH: CLC_0403(adhE) CLC_2050(eutE)
CBY: CLM_0413(adhE) CLM_2316(eutE)
CBL: CLK_1561(eutE) CLK_3533(adhE)
CBK: CLL_A1465
CBB: CLD_0407(adhE) CLD_2533(eutE)
CBI: CLJ_B0401(adhE) CLJ_B2312(eutE)
CBT: CLH_1388 CLH_1998
CBF: CLI_0416(adhE) CLI_2151(eutE)
CBE: Cbei_0305
CKL: CKL_1614(aad)
CKR: CKR_1499
CPY: Cphy_1428 Cphy_3925
CCE: Ccel_1083 Ccel_3198
AMT: Amet_3824
AOE: Clos_2387
DSY: DSY0406 DSY4993
DHD: Dhaf_1244
DRM: Dred_1305 Dred_1495 Dred_3266
DAE: Dtox_1709
PTH: PTH_0482(mhpF) PTH_1584
DAU: Daud_2043
HMO: HM1_2632(adhE)
FMA: FMG_0340
APR: Apre_1060
EEL: EUBELI_02054
TEX: Teth514_0627
TPD: Teth39_0206
CHY: CHY_1279(mhpF)
MTA: Moth_1776
HOR: Hore_02110
ACL: ACL_0177
MTU: Rv3535c
MTC: MT3639(mhpF)
MRA: MRA_3574(mhpF)
MTF: TBFG_13568
MTB: TBMG_03575(TBMG_03575.1)
MBO: Mb3565c
MBB: BCG_3599c
MBT: JTY_3600
MPA: MAP0532
MAV: MAV_0626
MSM: MSMEG_4149 MSMEG_5939
MUL: MUL_2436(mhpF) MUL_3976 MUL_4096(mhpF_1)
MVA: Mvan_0427 Mvan_0596 Mvan_5235
MGI: Mflv_1521
MAB: MAB_0625 MAB_4374
MMC: Mmcs_4660 Mmcs_5437
MKM: Mkms_4748 Mkms_5834
MJL: Mjls_4223 Mjls_5043
MMI: MMAR_1505(mhpF) MMAR_4110 MMAR_5022(mhpF_1)
NFA: nfa33190 nfa4660
RHA: RHA1_ro00516 RHA1_ro04534(hsaG)
RER: RER_07400 RER_57570
ROP: ROP_34170(cmtH) ROP_44490
GBR: Gbro_0910
SGR: SGR_565
JDE: Jden_1798
XCE: Xcel_2405
NCA: Noca_1650 Noca_2150
TCU: Tcur_3471
SRO: Sros_9114
FRE: Franean1_2883 Franean1_4744
NML: Namu_3211 Namu_4082
STP: Strop_3526
SAQ: Sare_3901 Sare_4566
BLO: BL1575(adh2)
BLJ: BLD_1704(putA2)
BLN: Blon_2241
BAD: BAD_0319
BLA: BLA_0358(adh)
BLC: Balac_0378
BLT: Balat_0378
APV: Apar_0133 Apar_0629
BHY: BHWA1_01768(adh)
LBA: Lebu_2076
STR: Sterm_1518
SMF: Smon_1052
EMI: Emin_0755 Emin_0772
RSD: TGRD_595
CYA: CYA_0473(adhE)
CYB: CYB_0241
TEL: tlr0227
MAR: MAE_49340
CYC: PCC7424_3674
CYN: Cyan7425_4050
AMR: AM1_0442
RRS: RoseRS_2572
RCA: Rcas_2411
CAU: Caur_1350
CAG: Cagg_2033
CHL: Chy400_1472
TRO: trd_1393
TTJ: TTHB247
TON: TON_0936
TGA: TGAM_1572(adh)
 |
|---|
| Structures |
PDB: 1NVM |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:13061511]
BURTON RM, STADTMAN ER.
The oxidation of acetaldehyde to acetyl coenzyme A.
J. Biol. Chem. 202 (1953) 873-90.
Clostridium kluyveri |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:7458347]
Smith LT, Kaplan NO.
Purification, properties, and kinetic mechanism of coenzyme A-linked
aldehyde dehydrogenase from Clostridium kluyveri.
Arch. Biochem. Biophys. 203 (1980) 663-75.
Clostridium kluyveri |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:8419288]
Powlowski J, Sahlman L, Shingler V.
Purification and properties of the physically associated
meta-cleavage pathway enzymes 4-hydroxy-2-ketovalerate aldolase and
aldehyde dehydrogenase (acylating) from Pseudomonas sp. strain
CF600.
J. Bacteriol. 175 (1993) 377-85.
Pseudomonas sp. |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.2.1.10
IUBMB Enzyme Nomenclature: 1.2.1.10
ExPASy - ENZYME nomenclature database: 1.2.1.10
BRENDA, the Enzyme Database: 1.2.1.10
CAS: 9028-91-5 |
|---|
