| Entry |
|
|---|
| Name |
malonate-semialdehyde dehydrogenase (acetylating);
malonic semialdehyde oxidative decarboxylase |
|---|
| Class |
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
 |
|---|
| Sysname |
3-oxopropanoate:NAD(P)+ oxidoreductase (decarboxylating,
CoA-acetylating) |
|---|
| Reaction(IUBMB) |
3-oxopropanoate + CoA + NAD(P)+ = acetyl-CoA + CO2 + NAD(P)H
[RN:R00705 R00706] |
|---|
| Reaction(KEGG) |
R00705 R00706;
(other) R00740 R03381
 |
|---|
| Substrate |
3-oxopropanoate [CPD:C00222];
CoA [CPD:C00010];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006] |
|---|
| Product |
acetyl-CoA [CPD:C00024];
CO2 [CPD:C00011];
NADH [CPD:C00004];
NADPH [CPD:C00005] |
|---|
| Pathway |
PATH: ec00410 beta-Alanine metabolism
PATH: ec00562 Inositol phosphate metabolism
PATH: ec00640 Propanoate metabolism
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K00136 malonate-semialdehyde dehydrogenase (acetylating) |
|---|
| Genes |
BJA: blr2174(iolD)
 |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:13712439]
HAYAISHI O, NISHIZUKA Y, TATIBANA M, TAKESHITA M, KUNO S.
Enzymatic studies on the metabolism of beta-alanine.
J. Biol. Chem. 236 (1961) 781-90.
Pseudomonas fluorescens |
|---|
Reference
Authors
Title
Journal
|
2
Jakoby, W.B.
Aldehyde dehydrogenases.
In: Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd
ed., vol. 7, Academic Press, New York, 1963, p. 203-221. |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:13846369]
YAMADA EW, JAKOBY WB.
Aldehyde oxidation. V. Direct conversion of malonic semialdehyde to
acetyl-coenzyme A.
J. Biol. Chem. 235 (1960) 589-94.
Pseudomonas fluorescens |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.2.1.18
IUBMB Enzyme Nomenclature: 1.2.1.18
ExPASy - ENZYME nomenclature database: 1.2.1.18
BRENDA, the Enzyme Database: 1.2.1.18
CAS: 9028-97-1 |
|---|
