| Entry |
|
|---|
| Name |
2-oxoaldehyde dehydrogenase (NAD+);
alpha-ketoaldehyde dehydrogenase;
methylglyoxal dehydrogenase;
NAD+-linked alpha-ketoaldehyde dehydrogenase;
2-ketoaldehyde dehydrogenase;
NAD+-dependent alpha-ketoaldehyde dehydrogenase;
2-oxoaldehyde dehydrogenase (NAD+) |
|---|
| Class |
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
 |
|---|
| Sysname |
2-oxoaldehyde:NAD+ 2-oxidoreductase |
|---|
| Reaction(IUBMB) |
a 2-oxoaldehyde + NAD+ + H2O = a 2-oxo acid + NADH + H+ [RN:R01337] |
|---|
| Reaction(KEGG) |
R01337 > R00203;
(other) R01735
 |
|---|
| Substrate |
2-oxoaldehyde [CPD:C00538];
NAD+ [CPD:C00003];
H2O [CPD:C00001] |
|---|
| Product |
2-oxo acid [CPD:C00161];
NADH [CPD:C00004];
H+ [CPD:C00080] |
|---|
| Comment |
Not identical with EC 1.2.1.49 2-oxoaldehyde dehydrogenase (NADP+). |
|---|
| Pathway |
PATH: ec00620 Pyruvate metabolism |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:4383524]
Monder C.
Alpha-keto aldehyde dehydrogenase, an enzyme that catalyzes the
enzymic oxidation of methylglyoxal to pyruvate.
J. Biol. Chem. 242 (1967) 4603-9.
Ovis aries |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:7107626]
Ray M, Ray S.
On the interaction of nucleotides and glycolytic intermediates with
NAD-linked alpha-ketoaldehyde dehydrogenase.
J. Biol. Chem. 257 (1982) 10571-4.
Capra hircus |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:7107625]
Ray S, Ray M.
Purification and characterization of NAD and NADP-linked
alpha-ketoaldehyde dehydrogenases involved in catalyzing the
oxidation of methylglyoxal to pyruvate.
J. Biol. Chem. 257 (1982) 10566-70.
Capra hircus |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.2.1.23
IUBMB Enzyme Nomenclature: 1.2.1.23
ExPASy - ENZYME nomenclature database: 1.2.1.23
BRENDA, the Enzyme Database: 1.2.1.23
CAS: 37250-91-2 |
|---|
