| Entry |
|
|---|
| Name |
2-oxoisovalerate dehydrogenase (acylating);
2-oxoisovalerate dehydrogenase;
alpha-ketoisovalerate dehydrogenase |
|---|
| Class |
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
 |
|---|
| Sysname |
3-methyl-2-oxobutanoate:NAD+ 2-oxidoreductase
(CoA-methyl-propanoylating) |
|---|
| Reaction(IUBMB) |
3-methyl-2-oxobutanoate + CoA + NAD+ = 2-methylpropanoyl-CoA + CO2 +
NADH [RN:R01210] |
|---|
| Reaction(KEGG) |
R01210;
(other) R01651 R03171
 |
|---|
| Substrate |
3-methyl-2-oxobutanoate [CPD:C00141];
CoA [CPD:C00010];
NAD+ [CPD:C00003] |
|---|
| Product |
2-methylpropanoyl-CoA [CPD:C00630];
CO2 [CPD:C00011];
NADH [CPD:C00004] |
|---|
| Comment |
Also acts on (S)-3-methyl-2-oxopentanoate and
4-methyl-2-oxopentanoate. |
|---|
| Pathway |
PATH: ec01063 Biosynthesis of alkaloids derived from shikimate
pathway |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:4308861]
Namba Y, Yoshizawa K, Ejima A, Hayashi T, Kaneda T.
Coenzyme A- and nicotinamide adenine dinucleotide-dependent branched
chain alpha-keto acid dehydrogenase. I. Purification and properties
of the enzyme from Bacillus subtilis.
J. Biol. Chem. 244 (1969) 4437-47.
Bacillus subtilis [GN:bsu] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.2.1.25
IUBMB Enzyme Nomenclature: 1.2.1.25
ExPASy - ENZYME nomenclature database: 1.2.1.25
BRENDA, the Enzyme Database: 1.2.1.25
CAS: 37211-61-3 |
|---|
