| Entry |
|
|---|
| Name |
2,5-dioxovalerate dehydrogenase;
2-oxoglutarate semialdehyde dehydrogenase;
alpha-ketoglutaric semialdehyde dehydrogenase |
|---|
| Class |
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
 |
|---|
| Sysname |
2,5-dioxopentanoate:NADP+ 5-oxidoreductase |
|---|
| Reaction(IUBMB) |
2,5-dioxopentanoate + NADP+ + H2O = 2-oxoglutarate + NADPH + 2 H+
[RN:R00264] |
|---|
| Reaction(KEGG) |
R00264
 |
|---|
| Substrate |
2,5-dioxopentanoate [CPD:C00433];
NADP+ [CPD:C00006];
H2O [CPD:C00001] |
|---|
| Product |
2-oxoglutarate [CPD:C00026];
NADPH [CPD:C00005];
H+ [CPD:C00080] |
|---|
| Pathway |
PATH: ec00053 Ascorbate and aldarate metabolism |
|---|
Reference
Authors
Title
Journal
|
1 [PMID:6024771]
Adams E, Rosso G
Alpha-ketoglutaric semialdehyde dehydrogenase of Pseudomonas.
Properties of the purified enzyme induced by hydroxyproline and of
the glucarate-induced and constitutive enzymes.
J. Biol. Chem. 242 (1967) 1802-14. |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.2.1.26
IUBMB Enzyme Nomenclature: 1.2.1.26
ExPASy - ENZYME nomenclature database: 1.2.1.26
BRENDA, the Enzyme Database: 1.2.1.26
CAS: 37250-92-3 |
|---|
