| Entry |
|
|---|
| Name |
methylmalonate-semialdehyde dehydrogenase (acylating);
MSDH;
MMSA dehydrogenase |
|---|
| Class |
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
 |
|---|
| Sysname |
2-methyl-3-oxopropanoate:NAD+ 3-oxidoreductase (CoA-propanoylating) |
|---|
| Reaction(IUBMB) |
2-methyl-3-oxopropanoate + CoA + H2O + NAD+ = propanoyl-CoA + HCO3-
+ NADH [RN:R00922] |
|---|
| Reaction(KEGG) |
R00922 > R00935;
(other) R00705
 |
|---|
| Substrate |
2-methyl-3-oxopropanoate [CPD:C00349];
CoA [CPD:C00010];
H2O [CPD:C00001];
NAD+ [CPD:C00003] |
|---|
| Product |
propanoyl-CoA [CPD:C00100];
HCO3- [CPD:C00288];
NADH [CPD:C00004] |
|---|
| Comment |
Also converts 3-oxopropanoate into acetyl-CoA [3]. The reaction
occurs in two steps with the decarboxylation process preceding
CoA-binding [3]. Bicarbonate rather than CO2 is released as a final
product [3]. |
|---|
| Pathway |
PATH: ec00280 Valine, leucine and isoleucine degradation
PATH: ec00562 Inositol phosphate metabolism
PATH: ec00640 Propanoate metabolism
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K00140 methylmalonate-semialdehyde dehydrogenase |
|---|
| Genes |
HSA: 4329(ALDH6A1)
PTR: 467506(ALDH6A1)
MCC: 698755(ALDH6A1)
MMU: 104776(Aldh6a1)
RNO: 81708(Aldh6a1)
CFA: 490779(ALDH6A1)
BTA: 327692(ALDH6A1)
SSC: 100153301
ECB: 100050834
MDO: 100024064
GGA: 423345(ALDH6A1)
TGU: 100226750
XLA: 734956
DRE: 436647
CIN: 100181655
SPU: 578337
DME: Dmel_CG17896
DPO: Dpse_GA14712
DAN: Dana_GF20808
DER: Dere_GG12757
DPE: Dper_GL20166
DSE: Dsec_GM19037
DSI: Dsim_GD16476
DYA: Dyak_GE16583
DGR: Dgri_GH24555
DMO: Dmoj_GI16236
AGA: AgaP_AGAP002499
AAG: AaeL_AAEL001134
CQU: CpipJ_CPIJ009984
AME: 409736
NVI: 100114161
TCA: 663091
API: 100168589
ISC: IscW_ISCW017171
CEL: F13D12.4(alh-8)
CBR: CBG03134
NVE: NEMVE_v1g177644
HMG: 100210762
TAD: TRIADDRAFT_36962
ATH: AT2G14170
POP: POPTR_202375 POPTR_846793
RCU: RCOM_0818850
VVI: 100266351
OSA: 4342610(Os07g0188800)
SBI: SORBI_02g005200(SORBIDRAFT_02g005200)
ZMA: 100274311(pco061337)
PPP: PHYPADRAFT_205382(ALDH6A)
CRE: CHLREDRAFT_130434
DHA: DEHA0C07711g
PIC: PICST_80168(ALD6)
PPA: PAS_chr4_0470
LEL: LELG_05618
CAL: CaO19.742(ALD6)
CTP: CTRG_03950
CDU: CD36_44770
YLI: YALI0C01859g
NCR: NCU09266
PAN: PODANSg10037
MGR: MGG_01606
FGR: FG00490.1 FG01826.1
ANI: AN3591.2
AFM: AFUA_4G12870
AOR: AO090009000314
ANG: An01g08430 An12g09680
AFV: AFLA_051530
PCS: Pc22g02810
NFI: NFIA_103470
CIM: CIMG_00614
URE: UREG_00620
SSL: SS1G_04782
BFU: BC1G_11821
CNE: CND02030 CNI01990
CNB: CNBD4330 CNBH1870
LBC: LACBIDRAFT_301007
MPR: MPER_09954
UMA: UM00214.1
MBR: MONBRDRAFT_37029
DDI: DDB_0231483
TGO: TGME49_111370
TET: TTHERM_00299840
PTM: GSPATT00008260001
PTI: PHATRDRAFT_23467
TPS: THAPSDRAFT_25495
ECQ: ECED1_0300
SPQ: SPAB_05567
SEA: SeAg_B4703(mmsA)
STM: STM4421
YPE: YPO2577
YPK: y1146
YPM: YP_1137(putA1)
YPA: YPA_2524
YPN: YPN_1061
YPG: YpAngola_A1877(mmsA)
YPP: YPDSF_2677
YPS: YPTB1071
YPI: YpsIP31758_2977(mmsA)
YPY: YPK_3049
YPB: YPTS_1126
YEN: YE4031
ECA: ECA1456
PCT: PC1_1334
PWA: Pecwa_3003
ETA: ETA_32930
PLU: plu1806
PAY: PAU_02709
CTU: Ctu_08920(iolA)
KPN: KPN_04670
KPE: KPK_4997(mmsA)
KPU: KP1_0552
CKO: CKO_03994
SPE: Spro_0606 Spro_4663
EIC: NT01EI_2137
DDC: Dd586_0706
DZE: Dd1591_3343
HAP: HAPS_1541
HSO: HS_1584
HSM: HSM_0427
AAP: NT05HA_1314
XCC: XCC1260(mmsA)
XCB: XC_2981
XCA: xccb100_3043
XCV: XCV1363
XAC: XAC1312(mmsA)
XOO: XOO1842(mmsA)
XOM: XOO_1738
XOP: PXO_01703(mmsA)
SML: Smlt0264
SMT: Smal_0219
VVU: VV2_0493
VVY: VVA1042
VPA: VPA0621 VPA1122
VHA: VIBHAR_05483
VEX: VEA_000374 VEA_001546
PPR: PBPRB0478 PBPRB1111
PAE: PA0130 PA0747 PA3570(mmsA)
PAU: PA14_01600(mmsA) PA14_18120(mmsA) PA14_54620
PAP: PSPA7_0206(mmsA3) PSPA7_1574(mmsA) PSPA7_4773(mmsA1)
PAG: PLES_01311 PLES_14631(mmsA) PLES_45961
PPU: PP_0597(mmsA-1) PP_4667(mmsA-2)
PPF: Pput_0637 Pput_4531
PPG: PputGB1_0642 PputGB1_4665
PPW: PputW619_0767 PputW619_2619 PputW619_4566
PST: PSPTO_0775(mmsA-1) PSPTO_0782(mmsA-2) PSPTO_3497(mmsA-3)
PSB: Psyr_0679 Psyr_0689 Psyr_3271
PSP: PSPPH_3191(mmsA1) PSPPH_4618(mmsA2)
PFL: PFL_0734(mmsA) PFL_0747(mmsA)
PFO: Pfl01_0686 Pfl01_0695
PFS: PFLU0676(mmsA) PFLU2292(mmsA) PFLU5203
PEN: PSEEN0682(mmsA-1) PSEEN0699(mmsA-2)
PMY: Pmen_0414 Pmen_1377 Pmen_3694 Pmen_4593
PSA: PST_0494(mmsA-1) PST_1926(mmsA-2)
AVN: Avin_10720 Avin_13890(mmsA) Avin_50080(iolA)
PAR: Psyc_0900(mmsA)
PCR: Pcryo_1517
PRW: PsycPRwf_0301
ACI: ACIAD1604(mmsA)
ACB: A1S_2232
ABM: ABSDF0121(mmsA)
ABY: ABAYE1296 ABAYE3768(mmsA)
ABC: ACICU_00129 ACICU_02438 ACICU_02615
ABN: AB57_0144(mmsA) AB57_2593(mmsA)
ABB: ABBFA_001208(mmsA) ABBFA_003416(mmsA)
SON: SO_1678(mmsA)
SDN: Sden_1942
SFR: Sfri_1339 Sfri_3023
SAZ: Sama_1376 Sama_2650
SBL: Sbal_1091 Sbal_1496
SBM: Shew185_1151 Shew185_1490
SBN: Sbal195_1185 Sbal195_1526
SBP: Sbal223_2855 Sbal223_3204
SLO: Shew_0965 Shew_1668
SPC: Sputcn32_1083 Sputcn32_1398
SSE: Ssed_1043 Ssed_1474
SPL: Spea_0935 Spea_2782
SHE: Shewmr4_2596 Shewmr4_2928
SHM: Shewmr7_2663 Shewmr7_3010
SHN: Shewana3_2770 Shewana3_3107
SHW: Sputw3181_2703 Sputw3181_3081
SHL: Shal_0985 Shal_2877
SWD: Swoo_1113 Swoo_3201
SWP: swp_3386 swp_4179
ILO: IL0870(mmsA)
CPS: CPS_0098(mmsA1) CPS_1432(mmsA2) CPS_3423(mmsA3) CPS_4060(mmsA4)
PHA: PSHAa1455
PAT: Patl_0948
MAQ: Maqu_2133
AMC: MADE_00766 MADE_01513
PIN: Ping_2399
CBU: CBU_0927(mmsA)
CBD: CBUD_1147(mmsA)
CBC: CbuK_0910(mmsA)
LPN: lpg0129(mmsA)
LPF: lpl0128
LPP: lpp0143
LPC: LPC_0149(mmsA)
HNA: Hneap_2368
HCH: HCH_00642(mmsA1) HCH_01157(mmsA2)
CSA: Csal_1126 Csal_2380
ABO: ABO_0020(mmsA)
MMW: Mmwyl1_1597 Mmwyl1_3349 Mmwyl1_3662 Mmwyl1_4044
AHA: AHA_0246(mmsA-1) AHA_2079(mmsA-2)
ASA: ASA_1913(mmsA) ASA_4152(mmsA)
CVI: CV_1437(mmsA2) CV_2085(mmsA1)
LHK: LHK_00216(mmsA1)
RSO: RS02392(RSp1055) RSc2536 RSp0650(mmsA)
RPI: Rpic_3975 Rpic_4274
RPF: Rpic12D_4088 Rpic12D_4384
REU: Reut_A0249 Reut_B4258 Reut_B5828 Reut_C5960
REH: H16_A0273(mmsA1) H16_A3664(mmsA2) H16_B1191(mmsA3)
RME: Rmet_0206
CTI: RALTA_A0213 RALTA_A3119 RALTA_B1109(mmsA)
BMA: BMA2931(mmsA-1) BMAA1379(mmsA-2)
BMV: BMASAVP1_0493(mmsA-2) BMASAVP1_A3379(mmsA)
BML: BMA10229_0157(mmsA-2) BMA10229_A1611(mmsA)
BMN: BMA10247_2990(mmsA) BMA10247_A1453(mmsA-2)
BPS: BPSL3420(msdA) BPSS0619(mmsA) BPSS0743
BPM: BURPS1710b_0202(mmsA) BURPS1710b_A2180(mmsA)
BURPS1710b_A2319(mmsA)
BPL: BURPS1106A_4070(mmsA) BURPS1106A_A0828(mmsA)
BURPS1106A_A1010(mmsA)
BPD: BURPS668_3996(mmsA) BURPS668_A0920(mmsA) BURPS668_A1097(mmsA)
BPR: GBP346_A4173(mmsA_1)
BTE: BTH_I3333(mmsA-1) BTH_II1657(mmsA-2) BTH_II1801(mmsA-3)
BVI: Bcep1808_1394 Bcep1808_3335 Bcep1808_4621 Bcep1808_4863
BUR: Bcep18194_A4576 Bcep18194_B0716 Bcep18194_B1697 Bcep18194_B2033
BCN: Bcen_0950 Bcen_3406 Bcen_4052 Bcen_4319
BCH: Bcen2424_1432 Bcen2424_4047 Bcen2424_4314 Bcen2424_4961
BCM: Bcenmc03_1410 Bcenmc03_3203 Bcenmc03_3478 Bcenmc03_5325
BCJ: BCAL1439(msdA) BCAM1151 BCAM1442 BCAM2194(mmsA)
BAM: Bamb_1312 Bamb_3442 Bamb_3730 Bamb_4383
BAC: BamMC406_1351 BamMC406_3949 BamMC406_4204 BamMC406_4812
BamMC406_4902
BMU: Bmul_1883 Bmul_3658 Bmul_4293 Bmul_4542
BMJ: BMULJ_01358(mmsA) BMULJ_03968(mmsA) BMULJ_04213(mmsA)
BMULJ_04859(mmsA)
BXE: Bxe_A0015 Bxe_A3576 Bxe_B1086 Bxe_B2023 Bxe_C0244
BPH: Bphy_4929 Bphy_5128 Bphy_5681
BPY: Bphyt_3917 Bphyt_5648 Bphyt_5814
BGL: bglu_1g10960 bglu_2g06280
PNU: Pnuc_1035 Pnuc_1559
BPE: BP1615 BP2417
BPA: BPP0783(mmsA) BPP2970 BPP3281
BBR: BB0868(mmsA) BB2936 BB3732
BPT: Bpet1775(mmsA1) Bpet4038(mmsA2)
BAV: BAV0503(mmsA) BAV1141 BAV1917(mmsA)
RFR: Rfer_0372
POL: Bpro_4547
PNA: Pnap_3801
AAV: Aave_2604 Aave_3822 Aave_4746
AJS: Ajs_2009 Ajs_4104
VEI: Veis_3532 Veis_4438
DAC: Daci_0980 Daci_3695
DIA: Dtpsy_1813 Dtpsy_3456
VAP: Vapar_3257 Vapar_3271
CTT: CtCNB1_2302 CtCNB1_2783
MPT: Mpe_A3524
HAR: HEAR3421(mmsA)
MMS: mma_3642(mmsA)
LCH: Lcho_3332
PCA: Pcar_2505(mmsA)
BBA: Bd1534(mmsA)
DPS: DP1915
ADE: Adeh_2245
ACP: A2cp1_1702
AFW: Anae109_1665
ANK: AnaeK_1629
MXA: MXAN_0121(mmsA)
SCL: sce6401(mmsA)
HOH: Hoch_6743
PUB: SAR11_0241(mmsA)
MLO: mll3987
MES: Meso_3319
PLA: Plav_1446
SME: SMc00781(iolA)
SMD: Smed_0324
ATU: Atu0205(mmsA)
ATC: AGR_C_351
ARA: Arad_0974(mmsA)
AVI: Avi_0836(mmsA)
RET: RHE_CH00731(iolA)
REC: RHECIAT_CH0000813(iolA)
RLE: RL0776(iolA)
RLT: Rleg2_0386
RLG: Rleg_0419
RHI: NGR_c03390
BME: BMEI0219
BMF: BAB1_1840(mmsA)
BMB: BruAb1_1811(mmsA)
BMC: BAbS19_I17200
BMS: BR1832(mmsA)
BMT: BSUIS_B1309(mmsA)
BOV: BOV_1765(mmsA)
BCS: BCAN_A1869(mmsA)
BMR: BMI_I1848(mmsA)
OAN: Oant_1068
BJA: blr3954
BRA: BRADO3137
BBT: BBta_3578
RPA: RPA3450
RPB: RPB_2117
RPC: RPC_3095
RPD: RPD_3302
RPE: RPE_2382
RPT: Rpal_3940
NWI: Nwi_2159
NHA: Nham_2559
OCA: OCAR_6889(mmsA) OCAR_7504(mmsA)
XAU: Xaut_2193 Xaut_3248
AZC: AZC_0575 AZC_4119
MEX: Mext_1282
MDI: METDI1870
MRD: Mrad2831_3785
MET: M446_1138 M446_2475
MPO: Mpop_4215
MCH: Mchl_1444
MNO: Mnod_2175 Mnod_2521
BID: Bind_0175 Bind_0618
CCR: CC_1302 CC_2274
CCS: CCNA_01360(iolA) CCNA_02357
CAK: Caul_1409
PZU: PHZ_c0206(mmsA1) PHZ_c1995
SIL: SPO2203(mmsA)
SIT: TM1040_1106
RSP: RSP_2962
RSH: Rsph17029_1609
RSQ: Rsph17025_1389
RSK: RSKD131_1285 RSKD131_3871
JAN: Jann_1913
RDE: RD1_2990(mmsA)
PDE: Pden_4479
DSH: Dshi_1747(mmsA)
MMR: Mmar10_2838
HNE: HNE_1828(mmsA1) HNE_2176(mmsA2)
HBA: Hbal_2703
NAR: Saro_0855
SAL: Sala_3049
SWI: Swit_0652 Swit_4138 Swit_5017
ELI: ELI_09995
ACR: Acry_1791 Acry_3021
GDI: GDI_0365(mmsA)
GDJ: Gdia_2416
APT: APA01_13920
RRU: Rru_A1542 Rru_A2071
BSU: BSU39760(mmsA)
BHA: BH2312
BAN: BA2354(mmsA-1) BA2513(mmsA-2)
BAR: GBAA2354(mmsA-1) GBAA2513(mmsA-2)
BAA: BA_2848 BA_3004
BAT: BAS2193 BAS2334
BAH: BAMEG_2089(mmsA2) BAMEG_2246(mmsA1)
BAI: BAA_2412(mmsA1) BAA_2569(mmsA2)
BCE: BC2290
BCA: BCE_2382(mmsA)
BCZ: BCZK2116(mmsA) BCZK2253(iolA) pE33L466_0301(iolA)
BCR: BCAH187_A2455(mmsA1)
BCB: BCB4264_A2320(mmsA1)
BCU: BCAH820_2373(mmsA1) BCAH820_2529(mmsA2)
BCG: BCG9842_B3004(mmsA1)
BCQ: BCQ_2281(mmsA)
BCX: BCA_2423(mmsA1) BCA_2598(mmsA2)
BCY: Bcer98_1729
BTK: BT9727_2130(mmsA) BT9727_2297(iolA)
BTL: BALH_2098 BALH_2259
BWE: BcerKBAB4_2161 BcerKBAB4_3173
BLI: BL00246(iolA) BL00293(mmsA)
BLD: BLi02104(mmsA) BLi04251
BCL: ABC0422(iolA) ABC1809
BAY: RBAM_036780(iolA)
BPU: BPUM_1749(mmsA)
OIH: OB0816 OB2736
GKA: GK1426 GK1887(iolA) GK1951
GTN: GTNG_1806 GTNG_1849
GWC: GWCH70_1319
GYM: GYMC10_3673
GYC: GYMC61_2217 GYMC61_2801
LMO: lmo0383
LMF: LMOf2365_0395(mmsA)
LMH: LMHCC_2253(mmsA)
LMC: Lm4b_00401
LIN: lin0401
LSP: Bsph_0921 Bsph_1308(mmsA) Bsph_2004
BBE: BBR47_32460(mmsA)
PJD: Pjdr2_1951
AAC: Aaci_0442
LCB: LCABL_02170(iolA)
LRH: LGG_00262(iolA)
LRL: LC705_00253(iolA)
MHY: mhp153(mmsA)
MHJ: MHJ_0219
MHP: MHP7448_0225
MTU: Rv0753c(mmsA)
MTC: MT0777(mmsA)
MRA: MRA_0762(mmsA)
MTF: TBFG_10767
MTB: TBMG_00767(TBMG_00767.1)
MBO: Mb0775c(mmsA)
MBB: BCG_0804c(mmsA)
MBT: JTY_0774(mmsA)
MPA: MAP4215c(mmsA)
MAV: MAV_2521(mmsA) MAV_4417(mmsA)
MSM: MSMEG_1498(mmsA) MSMEG_2449(mmsA)
MUL: MUL_0837(mmsA)
MVA: Mvan_1362 Mvan_1824
MGI: Mflv_0357 Mflv_5010
MAB: MAB_1189c MAB_4346c
MMC: Mmcs_0348 Mmcs_1064
MKM: Mkms_0358 Mkms_1080
MJL: Mjls_0337 Mjls_1091
MMI: MMAR_1079(mmsA)
CGL: NCgl0157(cgl0160) NCgl0521(cgl0544)
CGB: cg0199(msmA) cg0635
CGT: cgR_0239
CAR: cauri_0878(mmsA)
NFA: nfa10370
RHA: RHA1_ro01357(mmsA1) RHA1_ro01542(mmsA2) RHA1_ro04468(mmsA3)
RHA1_ro04548 RHA1_ro10225
RER: RER_20140(mmsA) RER_39550(mmsA)
ROP: ROP_05260(mmsA) ROP_10730 ROP_12450(mmsA) ROP_43860(mmsA)
ROP_44630(mmsA) ROP_72060(mmsA)
GBR: Gbro_3610 Gbro_3902
SCO: SCO2726(msdA)
SMA: SAV_5342(iolA)
SGR: SGR_1215 SGR_4838
CMI: CMM_0776
ART: Arth_0420 Arth_0823 Arth_1323
AAU: AAur_0499(mmsA) AAur_1941(mmsA) AAur_1980(mmsA)
ACH: Achl_0630 Achl_0940
RSA: RSal33209_1803 RSal33209_1851
KRH: KRH_16540(mmsA) KRH_23280(mmsA)
MLU: Mlut_01380 Mlut_02860
BCV: Bcav_0729 Bcav_4183
PAC: PPA0461
NCA: Noca_4626
TFU: Tfu_0687
TCU: Tcur_3379
SRO: Sros_1948
FRE: Franean1_3122 Franean1_3914
FAL: FRAAL1417(mmsA)
ACE: Acel_1799
NML: Namu_4538
KRA: Krad_1095
SEN: SACE_1456(mmsA2) SACE_4672(mmsA1) SACE_5185(mmsA3)
AMI: Amir_2105
STP: Strop_2992
SAQ: Sare_3214
CAI: Caci_7087
RXY: Rxyl_1716
AFO: Afer_0942
ABA: Acid345_1533
SUS: Acid_0680
DFE: Dfer_5699
CPI: Cpin_3442
STR: Sterm_4016
GAU: GAU_3553(mmsA)
HMU: Hmuk_0324
SSO: SSO1218
STO: ST1116
SIS: LS215_0412
SID: M164_0410
SIN: YN1551_2665
PAS: Pars_0509
KCR: Kcr_0497
 |
|---|
| Structures |
PDB: 1T90 |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:4297649]
Sokatch JR, Sanders LE, Marshall VP.
Oxidation of methylmalonate semialdehyde to propionyl coenzyme A in
Pseudomonas aeruginosa grown on valine.
J. Biol. Chem. 243 (1968) 2500-6.
Pseudomonas aeruginosa |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:15272169]
Dubourg H, Stines-Chaumeil C, Didierjean C, Talfournier F,
Rahuel-Clermont S, Branlant G, Aubry A.
Expression, purification, crystallization and preliminary X-ray
diffraction data of methylmalonate-semialdehyde dehydrogenase from
Bacillus subtilis.
Acta. Crystallogr. D. Biol. Crystallogr. 60 (2004) 1435-7.
Bacillus subtilis [GN:bsu] |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:16332250]
Stines-Chaumeil C, Talfournier F, Branlant G.
Mechanistic characterization of the MSDH (methylmalonate
semialdehyde dehydrogenase) from Bacillus subtilis.
Biochem. J. 395 (2006) 107-15.
Bacillus subtilis [GN:bsu] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.2.1.27
IUBMB Enzyme Nomenclature: 1.2.1.27
ExPASy - ENZYME nomenclature database: 1.2.1.27
BRENDA, the Enzyme Database: 1.2.1.27
CAS: 37205-49-5 |
|---|
