KEGG   ENZYME: 1.2.1.36Help
Entry
EC 1.2.1.36                 Enzyme                                 

Name
retinal dehydrogenase;
cytosolic retinal dehydrogenase
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
retinal:NAD+ oxidoreductase
Reaction(IUBMB)
retinal + NAD+ + H2O = retinoate + NADH + 2 H+ [RN:R02123]
Reaction(KEGG)
R02123;
(other) R08385
Show
Substrate
retinal [CPD:C00376];
NAD+ [CPD:C00003];
H2O [CPD:C00001]
Product
retinoate [CPD:C00777];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
A metalloflavoprotein (FAD). Acts on both the 11-trans- and 13-cis-forms of retinal.
History
EC 1.2.1.36 created 1972
Pathway
Retinol metabolism
Metabolic pathways
Orthology
K07249  
retinal dehydrogenase
Genes
HSA: 
216(ALDH1A1) 8854(ALDH1A2)
PTR: 
464529(ALDH1A1) 746847(ALDH1A2)
PPS: 
100976079(ALDH1A2) 100994654(ALDH1A1)
GGO: 
101135810(ALDH1A1) 101139899(ALDH1A2)
PON: 
100174688(ALDH1A1)
NLE: 
100584839(ALDH1A1) 100604565(ALDH1A2)
MCC: 
702235(ALDH1A2) 702598(ALDH1A1)
MCF: 
101865761(ALDH-E1) 101867250 102120533(ALDH1A2)
CJC: 
100407242(ALDH1A1) 100413342(ALDH1A2) 100414067(ALDH1A2)
MMU: 
11668(Aldh1a1) 19378(Aldh1a2) 26358(Aldh1a7)
RNO: 
116676(Aldh1a2) 24188(Aldh1a1) 29651(Aldh1a7)
CGE: 
HGL: 
101697212 101699741(Aldh1a2) 101706446(Aldh1a1)
TUP: 
102471053(ALDH1A2) 102479319(ALDH1A1)
CFA: 
476323(ALDH1A1) 478319(ALDH1A2)
AML: 
100468591(ALDH1A2)
UMR: 
103663346(ALDH1A1) 103663347 103676790(ALDH1A2)
FCA: 
101082916(ALDH1A2) 101090397(ALDH1A1)
PTG: 
102949007(ALDH1A2) 102949855(ALDH1A1)
BTA: 
281615(ALDH1A1) 535075(ALDH1A2)
BOM: 
102271327(ALDH1A2) 102280344(ALDH1A1)
PHD: 
102323401(ALDH1A2) 102329822(ALDH1A1)
CHX: 
102171605(ALDH1A1) 102181689(ALDH1A2)
OAS: 
101117509(ALDH1A2) 443343(ALDH1A1)
CFR: 
102516021(ALDH1A2) 102517350(ALDH1A1) 102521572
BACU: 
103001749(ALDH1A1) 103008947(ALDH1A2)
LVE: 
103073135(ALDH1A2) 103085237(ALDH1A1)
ECB: 
100054550(ALDH1A2) 100054931(ALDH1A1)
MYB: 
102245019(ALDH1A2) 102252022(ALDH1A1)
MYD: 
102755098(ALDH1A2) 102769215(ALDH1A1)
PALE: 
102895099(ALDH1A1) 102896470(ALDH1A2)
MDO: 
100019941(ALDH1A2) 100020742(ALDH1A1) 100020879(ALDH1A6)
SHR: 
OAA: 
100074461(ALDH1A1)
GGA: 
395264(ALDH1A1) 395844(ALDH1A2)
MGP: 
APLA: 
101801759(ALDH1A2) 101802481(ALDH1A1)
TGU: 
100223406(ALDH1A1) 751771(ALDH1A2)
FAB: 
101812539(ALDH1A1) 101813835(ALDH1A2)
PHI: 
102103267(ALDH1A1) 102111147(ALDH1A2)
FPG: 
101914714(ALDH1A1) 101919921(ALDH1A2)
FCH: 
102048413(ALDH1A1) 102051355(ALDH1A2)
CLV: 
102086687(ALDH1A2) 102091373(ALDH1A1)
ASN: 
102376803(ALDH1A2) 102378695(ALDH1A1)
AMJ: 
102558250(ALDH1A2) 102571914(ALDH1A1)
PSS: 
102446643(ALDH1A2) 102453636(ALDH1A1)
CMY: 
102943259(ALDH1A2) 102943361(ALDH1A1)
ACS: 
100556217(aldh1a2) 100566345(aldh1a1)
PBI: 
103055946(ALDH1A2) 103057171(ALDH1A1)
XLA: 
394296(aldh1-A) 397728(aldh1a1) 399389(aldh1a2)
XTR: 
613078(aldh1a1) 734052(aldh1a2)
DRE: 
116713(aldh1a2)
TRU: 
613232(raldh2)
MZE: 
OLA: 
100049450(aldh1a2)
XMA: 
LCM: 
102347553(ALDH1A1) 102352592(ALDH1A2)
CMK: 
103182367(aldh1a1) 103187113(aldh1a2)
BFO: 
LGI: 
NVE: 
NHE: 
NPA: 
DDI: 
TGO: 
 » show all
Taxonomy
Reference
1  [PMID:4312676]
  Authors
Moffa DJ, Lotspeich FJ, Krause RF.
  Title
Preparation and properties of retinal-oxidizing enzyme from rat intestinal mucosa.
  Journal
J. Biol. Chem. 245 (1970) 439-47.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
37250-99-0

DBGET integrated database retrieval system