KEGG   ENZYME: 1.2.1.36Help
Entry
EC 1.2.1.36                 Enzyme                                 
Name
retinal dehydrogenase;
cytosolic retinal dehydrogenase
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
retinal:NAD+ oxidoreductase
Reaction(IUBMB)
retinal + NAD+ + H2O = retinoate + NADH + 2 H+ [RN:R02123]
Reaction(KEGG)
R02123;
(other) R08385
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Substrate
retinal [CPD:C00376];
NAD+ [CPD:C00003];
H2O [CPD:C00001]
Product
retinoate [CPD:C00777];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
A metalloflavoprotein (FAD). Acts on both the 11-trans- and 13-cis-forms of retinal.
Pathway
Retinol metabolism
Metabolic pathways
Orthology
K07249  
retinal dehydrogenase
Genes
HSA: 
216(ALDH1A1) 8854(ALDH1A2)
PTR: 
464529(ALDH1A1) 746847(ALDH1A2)
PPS: 
100976079(ALDH1A2) 100994654(ALDH1A1)
GGO: 
101135810(ALDH1A1) 101139899(ALDH1A2)
PON: 
100174688(ALDH1A1)
MCC: 
702235(ALDH1A2) 702598(ALDH1A1)
MMU: 
11668(Aldh1a1) 19378(Aldh1a2) 26358(Aldh1a7)
RNO: 
116676(Aldh1a2) 24188(Aldh1a1) 29651(Aldh1a7)
CFA: 
476323(ALDH1A1) 478319(ALDH1A2)
AML: 
100468591(ALDH1A2)
FCA: 
101082916(ALDH1A2) 101090397(ALDH1A1)
BTA: 
281615(ALDH1A1) 535075(ALDH1A2)
SSC: 
100517137
ECB: 
100054550(ALDH1A2) 100054931
MDO: 
100019941(ALDH1A2) 100020742(ALDH1A1) 100020879(ALDH1A6)
SHR: 
100918704 100918961 100919222 100933258(ALDH1A2)
GGA: 
395264(ALDH1A1) 395844(ALDH1A2)
MGP: 
100545801
TGU: 
100223406(ALDH1A1) 751771(ALDH1A2)
ACS: 
100556217 100566345
XLA: 
394296(aldh1-A) 397728(aldh1a1) 399389(aldh1a2)
XTR: 
613078(aldh1a1) 734052(aldh1a2)
DRE: 
116713(aldh1a2)
TRU: 
613232(raldh2)
OLA: 
100049450(aldh1a2)
BFO: 
BRAFLDRAFT_113974 BRAFLDRAFT_206892(Aldh1a1/2/3f) BRAFLDRAFT_290739(Aldh1a1/2/3b)
NVE: 
NEMVE_v1g181421
DDI: 
DDB_G0290479(hydA)
TGO: 
TGME49_022160
 » show all
Taxonomy
Reference
1  [PMID:4312676]
  Authors
Moffa DJ, Lotspeich FJ, Krause RF.
  Title
Preparation and properties of retinal-oxidizing enzyme from rat intestinal mucosa.
  Journal
J. Biol. Chem. 245 (1970) 439-47.
  Organism
Rattus norvegicus [GN:rno]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
37250-99-0
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