| Entry |
|
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| Name |
aldehyde dehydrogenase [NAD(P)+];
aldehyde dehydrogenase [NAD(P)+];
ALDH |
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| Class |
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
 |
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| Sysname |
aldehyde:NAD(P)+ oxidoreductase |
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| Reaction(IUBMB) |
an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+ [RN:R00538
R00634] |
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| Reaction(KEGG) |
R00538 > R00631 R00710 R02536 R02695 R03300 R04882 R04888 R04891
R04996 R08282 R08307;
R00634 > R00711 R02537 R02697 R03302 R04883 R04889 R04892 R08283;
(other) R07104
 |
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| Substrate |
aldehyde [CPD:C00071];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006];
H2O [CPD:C00001] |
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| Product |
acid [CPD:C00174];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080] |
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| Pathway |
PATH: ec00010 Glycolysis / Gluconeogenesis
PATH: ec00340 Histidine metabolism
PATH: ec00350 Tyrosine metabolism
PATH: ec00360 Phenylalanine metabolism
PATH: ec00980 Metabolism of xenobiotics by cytochrome P450
PATH: ec00982 Drug metabolism - cytochrome P450
PATH: ec01100 Metabolic pathways |
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| Orthology |
KO: K00129 aldehyde dehydrogenase (NAD(P)+) |
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| Genes |
HSA: 218(ALDH3A1) 220(ALDH1A3) 221(ALDH3B1) 222(ALDH3B2)
PTR: 453686(ALDH1A3) 468186(ALDH3A1)
MCC: 694231(ALDH1A3) 703870(ALDH3A1) 710746(ALDH3B1) 721683(ALDH3B2)
MMU: 11670(Aldh3a1) 56847(Aldh1a3) 67689(Aldh3b1)
RNO: 25375(Aldh3a1) 266603(Aldh1a3) 309147(Aldh3b1)
CFA: 476003(ALDH3B1) 489526(ALDH3A1)
BTA: 281617(ALDH3A1) 507093(ALDH1A3) 511469(ALDH3B1)
ECB: 100053339(ALDH3B1) 100057072(ALDH1A3) 100073157
MDO: 100010416 100020131
OAA: 100077088 100083368
GGA: 395389(ALDH1A3) 428813(ALDH3B1)
TGU: 100231202 100232483
XLA: 733178(aldh1a3)
XTR: 100145787
DRE: 282559(aldh3d1) 751785(aldh1a3)
DME: Dmel_CG11140(Aldh-III)
CEL: T08B1.3(alh-5)
SCE: YMR169C(ALD3) YMR170C(ALD2)
AGO: AGOS_AFL201W
KLA: KLLA0D09999g
DHA: DEHA0G23991g
PIC: PICST_63844(ALD2)
VPO: Kpol_534p18
CAL: CaO19.13683
CGR: CAGL0F07777g
YLI: YALI0F04444g
SPO: SPAC922.07c
NCR: NCU00378
PAN: PODANSg4863
MGR: MGG_05008 MGG_07270
FGR: FG02273.1
ANI: AN1689.2
AFM: AFUA_4G08600 AFUA_4G13500
AOR: AO090023000697
ANG: An04g03400
NFI: NFIA_107580
SSL: SS1G_00782
BFU: BC1G_02079
PNA: Pnap_4188
ADE: Adeh_1143
BCZ: BCZK1178
BTK: BT9727_1176
CPR: CPR_2296
RHA: RHA1_ro01724
AVA: Ava_3615
CCH: Cag_1754
CPH: Cpha266_2158
 |
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| Structures |
PDB: 1AD3 1EYY 1EZ0 2AMF |
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Reference
Authors
Title
Journal
Organism
|
1 [PMID:14904038]
BLACK S.
Yeast aldehyde dehydrogenase.
Arch. Biochem. 34 (1951) 86-97.
Saccharomyces cerevisiae [GN:sce] |
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Reference
Authors
Title
Journal
|
2
Jakoby, W.B.
Aldehyde dehydrogenases.
In: Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd
ed., vol. 7, Academic Press, New York, 1963, p. 203-221. |
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Reference
Authors
Title
Journal
Organism
|
3 [PMID:13319337]
KING TE, CHELDELIN VH.
Oxidation of acetaldehyde by Acetobacter suboxydans.
J. Biol. Chem. 220 (1956) 177-91.
Aerobacter suboxydans |
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Reference
Authors
Title
Journal
Organism
|
4 [PMID:4293780]
Steinman CR, Jakoby WB.
Yeast aldehyde dehydrogenase. I. Purification and crystallization.
J. Biol. Chem. 242 (1967) 5019-23.
Acetobacter peroxidans |
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Reference
Authors
Title
Journal
Organism
|
5 [PMID:13363916]
TANENBAUM SW.
The metabolism of Acetobacter peroxidans. I. Oxidative enzymes.
Biochim. Biophys. Acta. 21 (1956) 335-42.
Acetobacter peroxidans |
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| Other DBs |
ExplorEnz - The Enzyme Database: 1.2.1.5
IUBMB Enzyme Nomenclature: 1.2.1.5
ExPASy - ENZYME nomenclature database: 1.2.1.5
BRENDA, the Enzyme Database: 1.2.1.5
CAS: 9028-88-0 |
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