| Entry |
|
|---|
| Name |
pyruvate dehydrogenase (NADP+);
pyruvate dehydrogenase (NADP+) |
|---|
| Class |
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
 |
|---|
| Sysname |
pyruvate:NADP+ 2-oxidoreductase (CoA-acetylating) |
|---|
| Reaction(IUBMB) |
pyruvate + CoA + NADP+ = acetyl-CoA + CO2 + NADPH [RN:R00210] |
|---|
| Reaction(KEGG) |
R00210
 |
|---|
| Substrate |
pyruvate [CPD:C00022];
CoA [CPD:C00010];
NADP+ [CPD:C00006] |
|---|
| Product |
acetyl-CoA [CPD:C00024];
CO2 [CPD:C00011];
NADPH [CPD:C00005] |
|---|
| Inhibitor |
Oxygen [CPD:C00007] |
|---|
| Comment |
The Euglena enzyme can also use FAD or methyl viologen as acceptor,
more slowly. The enzyme is inhibited by oxygen. |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:6438078]
Inui H, Miyatake K, Nakano Y, Kitaoka S.
Occurrence of oxygen-sensitive, NADP+-dependent pyruvate
dehydrogenase in mitochondria of Euglena gracilis.
J. Biochem. (Tokyo). 96 (1984) 931-4.
Euglena gracilis |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:3110154]
Inui H, Ono K, Miyatake K, Nakano Y, Kitaoka S.
Purification and characterization of pyruvate:NADP+ oxidoreductase
in Euglena gracilis.
J. Biol. Chem. 262 (1987) 9130-5.
Euglena gracilis |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.2.1.51
IUBMB Enzyme Nomenclature: 1.2.1.51
ExPASy - ENZYME nomenclature database: 1.2.1.51
BRENDA, the Enzyme Database: 1.2.1.51
CAS: 93389-35-6 |
|---|
