KEGG   ENZYME: 1.2.1.58Help
Entry
EC 1.2.1.58                 Enzyme                                 

Name
phenylglyoxylate dehydrogenase (acylating)
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
phenylglyoxylate:NAD+ oxidoreductase
Reaction(IUBMB)
phenylglyoxylate + NAD+ + CoA = benzoyl-S-CoA + CO2 + NADH [RN:R02450]
Reaction(KEGG)
Substrate
phenylglyoxylate [CPD:C02137];
NAD+ [CPD:C00003];
CoA [CPD:C00010]
Product
benzoyl-S-CoA;
CO2 [CPD:C00011];
NADH [CPD:C00004]
Comment
Requires thiamine diphosphate as cofactor. The enzyme from the denitrifying bacterium Azoarcus evansii is specific for phenylglyoxylate. 2-Oxoisovalerate is oxidized at 15% of the rate for phenylglyoxylate. Also reduces viologen dyes. Contains iron-sulfur centres and FAD.
History
EC 1.2.1.58 created 1999
Pathway
Phenylalanine metabolism
Orthology
K18355  
phenylglyoxylate dehydrogenase alpha subunit
K18356  
phenylglyoxylate dehydrogenase beta subunit
K18357  
phenylglyoxylate dehydrogenase gamma subunit
K18358  
phenylglyoxylate dehydrogenase delta subunit
K18359  
phenylglyoxylate dehydrogenase epsilon subunit
Genes
EBA: 
ebA5397(padE) ebA5399(padG) ebA5400(padH) ebA5401(padI) ebB191(padF)
AZA: 
AZKH_2897(padI) AZKH_2898(padH) AZKH_2899(padG) AZKH_2900(padF) AZKH_2901(padE)
TMZ: 
DTO: 
TOL2_C41570(padE2) TOL2_C41580(padF2) TOL2_C41590(padG2) TOL2_C41600(padH2) TOL2_C41610(padI2)
RPD: 
MAG: 
Taxonomy
Reference
1  [PMID:9490067]
  Authors
Hirsch W, Schagger H, Fuchs G.
  Title
Phenylglyoxylate:NAD+ oxidoreductase (CoA benzoylating), a new enzyme of anaerobic phenylalanine metabolism in the denitrifying bacterium Azoarcus evansii.
  Journal
Eur. J. Biochem. 251 (1998) 907-15.
  Organism
Azoarcus evansii
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
205510-78-7

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