| Entry |
|
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| Name |
aldehyde oxidase;
quinoline oxidase |
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| Class |
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With oxygen as acceptor
 |
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| Sysname |
aldehyde:oxygen oxidoreductase |
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| Reaction(IUBMB) |
an aldehyde + H2O + O2 = a carboxylic acid + H2O2 [RN:R00635] |
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| Reaction(KEGG) |
R00635 > R02657 R03871 R04904 R08349;
(other) R01709 R04085 R08408
 |
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| Substrate |
aldehyde [CPD:C00071];
H2O [CPD:C00001];
O2 [CPD:C00007] |
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| Product |
carboxylic acid [CPD:C00060];
H2O2 [CPD:C00027] |
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| Cofactor |
FAD [CPD:C00016];
Heme [CPD:C00032];
Molybdenum [CPD:C00150];
Iron-sulfur [CPD:C00824] |
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| Comment |
Contains molybdenum, [2Fe-2S] centres and FAD. Also oxidizes
quinoline and pyridine derivatives. May be identical with EC
1.2.3.11, retinal oxidase. |
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| Pathway |
PATH: ec00280 Valine, leucine and isoleucine degradation
PATH: ec00350 Tyrosine metabolism
PATH: ec00380 Tryptophan metabolism
PATH: ec00750 Vitamin B6 metabolism
PATH: ec00760 Nicotinate and nicotinamide metabolism
PATH: ec00982 Drug metabolism - cytochrome P450
PATH: ec01100 Metabolic pathways |
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| Orthology |
KO: K00157 aldehyde oxidase |
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| Genes |
HSA: 316(AOX1)
MCC: 701024 701613
MMU: 11761(Aox1)
RNO: 316421(Aox3l1) 54349(Aox1)
CFA: 608849(AOH3)
BTA: 338074(AOX1) 531699
ECB: 100070976(AOX1) 100146423
MDO: 100016433 100029977
GGA: 424071(AOX1)
TGU: 100217503
XLA: 444490
DRE: 570457(aox1)
BUR: Bcep18194_A3924
RDE: RD1_1533(mop)
 |
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| Structures |
PDB: 1SIJ 1VLB |
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Reference
Authors
Title
Journal
|
1 [PMID:16747217]
Gordon AH, Green DE, Subrahmanyan V
Liver aldehyde oxidase.
Biochem. J. 34 (1940) 764-74. |
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Reference
Authors
Title
Journal
|
2
Knox, W.E.
The quinine-oxidizing enzyme and liver aldehyde oxidase.
J. Biol. Chem. 163 (1946) 699-711. |
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Reference
Authors
Title
Journal
Organism
|
3 [PMID:13201608]
MAHLER HR, MACKLER B, GREEN DE.
Studies on metalloflavoproteins. III. Aldehyde oxidase: a
molybdoflavoprotein.
J. Biol. Chem. 210 (1954) 465-80.
Sus scofa [GN:ssc] |
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Reference
Authors
Title
Journal
Organism
|
4 [PMID:10190983]
Huang DY, Furukawa A, Ichikawa Y.
Molecular cloning of retinal oxidase/aldehyde oxidase cDNAs from
rabbit and mouse livers and functional expression of recombinant
mouse retinal oxidase cDNA in Escherichia coli.
Arch. Biochem. Biophys. 364 (1999) 264-72.
Mus musculus [GN:mmu], Oryctolagus cuniculus |
|---|
Reference
Authors
Title
Journal
Organism
|
5 [PMID:14659539]
Uchida H, Kondo D, Yamashita A, Nagaosa Y, Sakurai T, Fujii Y,
Fujishiro K, Aisaka K, Uwajima T.
Purification and characterization of an aldehyde oxidase from
Pseudomonas sp. KY 4690.
FEMS. Microbiol. Lett. 229 (2003) 31-6.
Pseudomonas sp. |
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| Other DBs |
ExplorEnz - The Enzyme Database: 1.2.3.1
IUBMB Enzyme Nomenclature: 1.2.3.1
ExPASy - ENZYME nomenclature database: 1.2.3.1
UM-BBD (Biocatalysis/Biodegradation Database): 1.2.3.1
BRENDA, the Enzyme Database: 1.2.3.1
CAS: 9029-07-6 |
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