| Entry |
|
|---|
| Name |
pyruvate synthase;
pyruvate oxidoreductase;
pyruvate synthetase;
pyruvate:ferredoxin oxidoreductase;
pyruvic-ferredoxin oxidoreductase |
|---|
| Class |
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With an iron-sulfur protein as acceptor
 |
|---|
| Sysname |
pyruvate:ferredoxin 2-oxidoreductase (CoA-acetylating) |
|---|
| Reaction(IUBMB) |
pyruvate + CoA + 2 oxidized ferredoxin = acetyl-CoA + CO2 + 2
reduced ferredoxin + 2 H+ [RN:R01196] |
|---|
| Reaction(KEGG) |
R01196;
(other) R01199 R08034
 |
|---|
| Substrate |
pyruvate [CPD:C00022];
CoA [CPD:C00010];
oxidized ferredoxin [CPD:C00139] |
|---|
| Product |
acetyl-CoA [CPD:C00024];
CO2 [CPD:C00011];
reduced ferredoxin [CPD:C00138];
H+ [CPD:C00080] |
|---|
| Comment |
Contains thiamine diphosphate and [4Fe-4S] clusters. This enzyme is
one of four2-oxoacid oxidoreductases that are differentiated by
their abilities to oxidatively decarboxylatedifferent 2-oxoacids and
form their CoA derivatives [see also EC 1.2.7.3, 2-oxoglutarate
synthase, EC 1.2.7.7, 3-methyl-2-oxobutanoate dehydrogenase
(ferredoxin) and EC 1.2.7.8, indolepyruvate ferredoxin
oxidoreductase] |
|---|
| Pathway |
PATH: ec00010 Glycolysis / Gluconeogenesis
PATH: ec00020 Citrate cycle (TCA cycle)
PATH: ec00620 Pyruvate metabolism
PATH: ec00633 Trinitrotoluene degradation
PATH: ec00640 Propanoate metabolism
PATH: ec00650 Butanoate metabolism
PATH: ec00720 Reductive carboxylate cycle (CO2 fixation)
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K00169 pyruvate ferredoxin oxidoreductase, alpha subunit
KO: K00170 pyruvate ferredoxin oxidoreductase, beta subunit
KO: K00171 pyruvate ferredoxin oxidoreductase, delta subunit
KO: K00172 pyruvate ferredoxin oxidoreductase, gamma subunit |
|---|
| Genes |
RFR: Rfer_2185 Rfer_2186 Rfer_2187
LCH: Lcho_2149 Lcho_2150 Lcho_2151
EBA: ebA5397(padE) ebA5399(padG) ebA5401(padI) ebB191(padF)
APP: CAP2UW1_2510 CAP2UW1_2511 CAP2UW1_2512
HPY: HP1108(porC) HP1109(porD) HP1110(porA) HP1111
HPJ: jhp1035(porG) jhp1036(porD) jhp1037(porA) jhp1038(porB)
HPA: HPAG1_1047(porC) HPAG1_1048(porD) HPAG1_1049(porA) HPAG1_1050
HPS: HPSH_05695 HPSH_05700(porD) HPSH_05705(porA) HPSH_05710
HPG: HPG27_1050 HPG27_1051(porD) HPG27_1052(porA) HPG27_1053
HPP: HPP12_1073(porG) HPP12_1074(porD) HPP12_1075(porA)
HPP12_1076(porB)
HPB: HELPY_1077(porG) HELPY_1078(porD) HELPY_1079(porA)
HELPY_1081(porB)
HHE: HH0546(porB) HH0547(porA) HH0548(porD) HH0549(porG)
HAC: Hac_0430(porB) Hac_0431(porA) Hac_0432(porD) Hac_0433(porG)
WSU: WS2128 WS2130(porA) WS2131(porD) WS2132(porC)
TDN: Suden_0096(porC) Suden_0097(porD) Suden_0098(porA) Suden_0099
NIS: NIS_1602 NIS_1603(porA) NIS_1604(porD) NIS_1605
SUN: SUN_0198(porC) SUN_0199(porD) SUN_0200(porA) SUN_0201(porB)
NAM: NAMH_0240 NAMH_0241 NAMH_0242 NAMH_0243
PCA: Pcar_1238 Pcar_1239 Pcar_1240
PPD: Ppro_0319 Ppro_0322 Ppro_0323 Ppro_0324 Ppro_0325 Ppro_0470
Ppro_0471 Ppro_0472
DPS: DP1199 DP1200 DP1201
DOL: Dole_1391 Dole_1392 Dole_1393 Dole_1394
SAT: SYN_00154 SYN_00155 SYN_00156 SYN_00157 SYN_00691 SYN_00692
SYN_00693 SYN_00694
SFU: Sfum_0114 Sfum_0115 Sfum_0543 Sfum_0544 Sfum_2792 Sfum_2793
Sfum_2794 Sfum_2795
RPD: RPD_1510 RPD_1511 RPD_1512 RPD_1514
MAG: amb1676 amb1677 amb1678 amb1680
GTN: GTNG_1717(porA) GTNG_1718(porG)
GYM: GYMC10_1000 GYMC10_1001
CTC: CTC02525(porB) CTC02526(porA) CTC02527(porD) CTC02528(porC)
CNO: NT01CX_0144(porB) NT01CX_0145 NT01CX_0146(porD)
NT01CX_0147(porG)
CTH: Cthe_2390 Cthe_2391 Cthe_2392 Cthe_2393 Cthe_2794 Cthe_2795
Cthe_2796
CKL: CKL_2996(porB) CKL_2997(porA) CKL_2998(porD) CKL_2999(porC)
CKR: CKR_2646 CKR_2647 CKR_2648 CKR_2649
STH: STH3262 STH3264
SWO: Swol_1374 Swol_1375 Swol_1376 Swol_1377 Swol_2234 Swol_2235
Swol_2236 Swol_2237
ATE: Athe_0874 Athe_0875 Athe_0876 Athe_0877 Athe_1708 Athe_1709
DAU: Daud_1962 Daud_1963 Daud_1964 Daud_1965 Daud_1966
FMA: FMG_0216 FMG_0217 FMG_0218
MTA: Moth_0376 Moth_0377 Moth_0378 Moth_0379 Moth_1591 Moth_1592
Moth_1593 Moth_1921 Moth_1922 Moth_1923 Moth_1924
CSC: Csac_1458 Csac_1459 Csac_1460 Csac_1461 Csac_2248 Csac_2249
CPO: COPRO5265_1196 COPRO5265_1197 COPRO5265_1198 COPRO5265_1199
HOR: Hore_20710 Hore_20720 Hore_20730 Hore_20740
NCA: Noca_2359 Noca_2360 Noca_2361
ACE: Acel_0700 Acel_0701 Acel_0702
RXY: Rxyl_0920 Rxyl_0921
CCU: Ccur_08360 Ccur_08370 Ccur_08380
ELE: Elen_0417 Elen_0418
BHY: BHWA1_01937(porG) BHWA1_01938(porA)
RMR: Rmar_2583 Rmar_2584 Rmar_2585
RSD: TGRD_278 TGRD_279 TGRD_280 TGRD_281
DET: DET0724(porG) DET0725(porD) DET0726(porA) DET0727(porB)
DEH: cbdb_A680(porD) cbdb_A681(porA) cbdb_A682(porB) cbdb_B16(porG)
DEB: DehaBAV1_0656 DehaBAV1_0657 DehaBAV1_0658 DehaBAV1_0659
DEV: DhcVS_630 DhcVS_631 DhcVS_632 DhcVS_633
AAE: aq_1167(forA2) aq_1168(forB2) aq_1169(forG2) aq_1195(forA1)
aq_1196(forB1) aq_1200(forG1)
HYA: HY04AAS1_0040 HY04AAS1_0041 HY04AAS1_0042 HY04AAS1_1635
HY04AAS1_1636 HY04AAS1_1637
SUL: SYO3AOP1_0612 SYO3AOP1_0613 SYO3AOP1_0614 SYO3AOP1_0615
SAF: SULAZ_0642 SULAZ_0643 SULAZ_0644 SULAZ_0645 SULAZ_0655
SULAZ_0656 SULAZ_0657
PMX: PERMA_0528 PERMA_0529 PERMA_0530 PERMA_0531
TMA: TM0015 TM0016 TM0017 TM0018
TPT: Tpet_0905 Tpet_0906 Tpet_0907 Tpet_0908
TLE: Tlet_1774 Tlet_1775 Tlet_1776 Tlet_1777
TRQ: TRQ2_0927 TRQ2_0928 TRQ2_0929 TRQ2_0930
TNA: CTN_0680 CTN_0681 CTN_0682 CTN_0683
TNP: Tnap_0646 Tnap_0647 Tnap_0648 Tnap_0649
TME: Tmel_0340 Tmel_0341 Tmel_0342 Tmel_0343
TAF: THA_518 THA_519 THA_520 THA_521
FNO: Fnod_0863 Fnod_0864 Fnod_0865 Fnod_0866
PMO: Pmob_0584 Pmob_0585 Pmob_0586 Pmob_0587
KOL: Kole_0379 Kole_0380 Kole_0381 Kole_0382
DTH: DICTH_1983 DICTH_1984 DICTH_1985 DICTH_1986
DTU: Dtur_0260 Dtur_0261 Dtur_0262 Dtur_0263
TYE: THEYE_A0907 THEYE_A0908 THEYE_A0909 THEYE_A0910
MJA: MJ0266 MJ0267 MJ0268 MJ0269
MFE: Mefer_0883 Mefer_0884 Mefer_0885 Mefer_0886
MVU: Metvu_1157 Metvu_1158 Metvu_1159 Metvu_1160
MMP: MMP1504(porB) MMP1505(porA) MMP1506(porD) MMP1507(porC)
MMQ: MmarC5_0070 MmarC5_0071 MmarC5_0072 MmarC5_0073
MMX: MmarC6_1167 MmarC6_1168 MmarC6_1169 MmarC6_1170
MMZ: MmarC7_0748 MmarC7_0749 MmarC7_0750 MmarC7_0751
MAE: Maeo_0462 Maeo_0463 Maeo_0464 Maeo_0465 Maeo_1281 Maeo_1282
Maeo_1283 Maeo_1284
MVN: Mevan_0813 Mevan_0814 Mevan_0815 Mevan_0816
MAC: MA0031(porB) MA0032(porA) MA0033(porD) MA0034(porG)
MA2407(porB)
MBA: Mbar_A0999 Mbar_A1000 Mbar_A1001 Mbar_A1002 Mbar_A3180
MMA: MM_1339 MM_1340 MM_1341 MM_1342
MBU: Mbur_2155 Mbur_2156 Mbur_2157 Mbur_2158
MTP: Mthe_1645 Mthe_1646 Mthe_1647 Mthe_1648
MHU: Mhun_0450 Mhun_0451 Mhun_0452 Mhun_0453 Mhun_2393 Mhun_2394
Mhun_2395 Mhun_2396
MLA: Mlab_0047 Mlab_0048 Mlab_0049 Mlab_0050 Mlab_1415 Mlab_1416
Mlab_1417 Mlab_1418
MEM: Memar_0707 Memar_0708 Memar_0709 Memar_0710 Memar_2318
Memar_2319 Memar_2320 Memar_2321
MBN: Mboo_0170 Mboo_0171 Mboo_0172 Mboo_0173 Mboo_0202 Mboo_0203
Mboo_0204 Mboo_0205 Mboo_0672 Mboo_0673 Mboo_0674 Mboo_0675
MPL: Mpal_2013 Mpal_2014 Mpal_2015 Mpal_2016 Mpal_2716 Mpal_2717
Mpal_2718 Mpal_2719
MPD: MCP_1255 MCP_1256 MCP_1257 MCP_1258 MCP_2611 MCP_2612 MCP_2613
MCP_2614
MTH: MTH1738 MTH1739 MTH1740
MST: Msp_0334(porC) Msp_0335(porD) Msp_0336(porA) Msp_0337(porB)
MSI: Msm_0557 Msm_0558 Msm_0559 Msm_0560
MKA: MK0080(porG_1) MK0081(porD) MK0082(porA_1) MK0083(porB_1)
AFU: AF1699(porG) AF1700(porD) AF1701(porA) AF1702(porB)
AF2052(vorB) AF2053(vorA) AF2054(vorD) AF2055(vorG)
HUT: Huta_1479 Huta_1480 Huta_1481 Huta_1482
TAC: Ta0626m Ta0627 Ta0628m Ta0629
TVO: TVN0833 TVN0834 TVN0835 TVN0836
PHO: PH0682(porD) PH0684(porA) PH0685
PAB: PAB1474(porD) PAB1475(porA) PAB1476
PFU: PF0965 PF0966(porA) PF0967(porD)
TKO: TK1982(porD) TK1983(porA) TK1984
TON: TON_1480(porD) TON_1481(porA) TON_1482
TGA: TGAM_0261(porB) TGAM_0262(porA) TGAM_0263(porD) TGAM_0264(vorB)
TGAM_0265(vorA) TGAM_0267(porG)
TSI: TSIB_1378 TSIB_1379 TSIB_1380 TSIB_1381 TSIB_1382 TSIB_1384
RCI: RCIX486(porC-1) RCIX488(porD-1) RCIX489(porA-1) RCIX490(porB-1)
RRC106(porB-2) RRC107(porA-2) RRC109(porC-2) RRC110(porD-2)
SMR: Smar_0997 Smar_0998 Smar_0999 Smar_1000 Smar_1447 Smar_1448
Smar_1449 Smar_1450
IHO: Igni_1256 Igni_1257 Igni_1258 Igni_1259
DKA: DKAM_0578 DKAM_0579 DKAM_0580 DKAM_0581 DKAM_1185 DKAM_1186
DKAM_1187 DKAM_1188
HBU: Hbut_0667 Hbut_0668 Hbut_0669 Hbut_0670 Hbut_0729 Hbut_0730
Hbut_0731 Hbut_0732
SSO: SSO11071(porD-2) SSO1206(porB-1) SSO1207(porA-1)
SSO1208(porG-1) SSO2128(porD-like) SSO2129(porA-like)
SSO2130(porB-like) SSO2756(porB-2) SSO2757(porA-2)
SSO2758(porG-2) SSO7412(porD-1)
STO: ST1531 ST1532 ST1533 ST1787 ST1788
SAI: Saci_1088 Saci_2250(porC) Saci_2251(porD) Saci_2252(porA)
Saci_2253(porB)
SIS: LS215_0368 LS215_0369 LS215_0370 LS215_0395 LS215_0396
LS215_0397 LS215_0398 LS215_2725 LS215_2726 LS215_2727
LS215_2728
SIA: M1425_0343 M1425_0344 M1425_0345 M1425_0371 M1425_0372
M1425_0373 M1425_0374 M1425_2566 M1425_2567 M1425_2568
M1425_2569
SIM: M1627_0344 M1627_0345 M1627_0346 M1627_0379 M1627_0380
M1627_0381 M1627_0382 M1627_2619 M1627_2620 M1627_2621
M1627_2622
SID: M164_0364 M164_0365 M164_0395 M164_0396 M164_0397 M164_0398
M164_2550 M164_2551 M164_2552 M164_2553 M164_2843
SIY: YG5714_0360 YG5714_0361 YG5714_0362 YG5714_0373 YG5714_0374
YG5714_0375 YG5714_0376 YG5714_2728 YG5714_2729 YG5714_2730
YG5714_2731
SIN: YN1551_0157 YN1551_0158 YN1551_0159 YN1551_0160 YN1551_2679
YN1551_2680 YN1551_2681 YN1551_2682 YN1551_2709 YN1551_2710
YN1551_2711
MSE: Msed_0306 Msed_0307 Msed_0308 Msed_0309 Msed_0507 Msed_0508
Msed_0509 Msed_0510 Msed_1199 Msed_1200 Msed_1201
PAI: PAE1040 PAE1041 PAE1042 PAE1043 PAE3274 PAE3275 PAE3276 PAE3279
PIS: Pisl_0324 Pisl_0325 Pisl_0326 Pisl_0497 Pisl_0498 Pisl_0499
Pisl_0500 Pisl_1230 Pisl_1231 Pisl_1232 Pisl_1233
PCL: Pcal_0665 Pcal_0666 Pcal_0667 Pcal_0668 Pcal_1767 Pcal_1768
Pcal_1769 Pcal_1770 Pcal_2050 Pcal_2051 Pcal_2052
PAS: Pars_0193 Pars_0194 Pars_0195 Pars_0196 Pars_1705 Pars_1706
Pars_1707 Pars_1708 Pars_2277 Pars_2278 Pars_2279
CMA: Cmaq_1710 Cmaq_1711 Cmaq_1712 Cmaq_1713 Cmaq_1860 Cmaq_1861
Cmaq_1862 Cmaq_1863
TNE: Tneu_0176 Tneu_0177 Tneu_0178 Tneu_0179 Tneu_1526 Tneu_1527
Tneu_1528 Tneu_1529 Tneu_1795 Tneu_1796 Tneu_1797
TPE: Tpen_0540 Tpen_0541 Tpen_0542 Tpen_0543 Tpen_0571 Tpen_0572
Tpen_0573 Tpen_0574
KCR: Kcr_1226 Kcr_1227 Kcr_1228 Kcr_1229 Kcr_1291 Kcr_1292 Kcr_1293
Kcr_1525
 |
|---|
| Structures |
PDB: 1B0P 1KEK 2C3M 2C3O 2C3P 2C3U 2C3Y 2C42 2PDA 2RAA
2UZA |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:5217644]
Evans MC, Buchanan BB.
Photoreduction of ferredoxin and its use in carbon dioxide fixation
by a subcellular system from a photosynthetic bacterium.
Proc. Natl. Acad. Sci. U. S. A. 53 (1965) 1420-5.
Chlorobium thiosulfatophilum, Chromatium sp. |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:4628267]
Gehring U, Arnon DI.
Purification and properties of -ketoglutarate synthase from a
photosynthetic bacterium.
J. Biol. Chem. 247 (1972) 6963-9.
Chlorobium thiosulfatophilum, Chromatium sp. |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:5574389]
Uyeda K, Rabinowitz JC.
Pyruvate-ferredoxin oxidoreductase. 3. Purification and properties
of the enzyme.
J. Biol. Chem. 246 (1971) 3111-9.
Clostridium acidi-urici |
|---|
Reference
Authors
Title
Journal
Organism
|
4 [PMID:4324891]
Uyeda K, Rabinowitz JC.
Pyruvate-ferredoxin oxidoreductase. IV. Studies on the reaction
mechanism.
J. Biol. Chem. 246 (1971) 3120-5.
Clostridium acidi-urici |
|---|
Reference
Authors
Title
Journal
Organism
|
5 [PMID:10607667]
Charon MH, Volbeda A, Chabriere E, Pieulle L, Fontecilla-Camps JC.
Structure and electron transfer mechanism of pyruvate:ferredoxin
oxidoreductase.
Curr. Opin. Struct. Biol. 9 (1999) 663-9.
Clostridium thermoaceticum |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.2.7.1
IUBMB Enzyme Nomenclature: 1.2.7.1
ExPASy - ENZYME nomenclature database: 1.2.7.1
BRENDA, the Enzyme Database: 1.2.7.1
CAS: 9082-51-3 |
|---|
