KEGG   ENZYME: 1.2.7.5Help
Entry
EC 1.2.7.5                  Enzyme                                 

Name
aldehyde ferredoxin oxidoreductase;
AOR
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With an iron-sulfur protein as acceptor
BRITE hierarchy
Sysname
aldehyde:ferredoxin oxidoreductase
Reaction(IUBMB)
an aldehyde + H2O + 2 oxidized ferredoxin = a carboxylate + 2 H+ + 2 reduced ferredoxin [RN:R07158]
Reaction(KEGG)
Substrate
aldehyde [CPD:C00071];
H2O [CPD:C00001];
oxidized ferredoxin [CPD:C00139]
Product
carboxylate [CPD:C00060];
H+ [CPD:C00080];
reduced ferredoxin [CPD:C00138]
Comment
This is an oxygen-sensitive enzyme that contains tungsten-molybdopterin and iron-sulfur clusters. Catalyses the oxidation of aldehydes (including crotonaldehyde, acetaldehyde, formaldehyde and glyceraldehyde) to their corresponding acids. However, it does not oxidize glyceraldehyde 3-phosphate [see EC 1.2.7.6, glyceraldehyde-3-phosphate dehydrogenase (ferredoxin)]. Can use ferredoxin or methylviologen but not NAD(P)+ as electron acceptor.
History
EC 1.2.7.5 created 2003
Pathway
ec00030  Pentose phosphate pathway
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K03738  aldehyde:ferredoxin oxidoreductase
Genes
SBL: Sbal_3096
SPC: Sputcn32_1189
SSE: Ssed_2568
SPL: Spea_0261
SHW: Sputw3181_2975
MAH: MEALZ_0765(aor)
CYQ: Q91_2116
CZA: CYCME_0309
CYY: CPC19_02230
AEH: Mlg_1297
GAI: IMCC3135_00275(ydhV)
RFR: Rfer_2850
PNA: Pnap_0049
AJS: Ajs_3944
LIH: L63ED372_00732(ydhV)
MPT: Mpe_A2581
LCH: Lcho_1817
TIN: Tint_2646
THI: THI_3176(aor)
SHD: SUTH_02126(aorA)
METR: BSY238_618
EBA: ebA5005
AZO: azo2930(aorA)
AZA: AZKH_1616(aorA)
AOA: dqs_3070
TCL: Tchl_1915
WSU: WS1844
SDL: Sdel_1699
SMUL: SMUL_2394(aor)
SHAL: SHALO_2143
SULJ: SJPD1_2154
GME: Gmet_1045(aorA) Gmet_2289
GLO: Glov_2231
PCA: Pcar_0254(aorA-1) Pcar_0456(aorA-2) Pcar_0665(aorA-3) Pcar_2514 Pcar_2853(aorA-4)
DVU: DVU0687 DVU1179(aor)
DDS: Ddes_1775
DPS: DP2476
DML: Dmul_08440(aor2) Dmul_24460(bamB1) Dmul_28730(aor3)
DAT: HRM2_02020(aor1) HRM2_04880(aor2) HRM2_05270(aor3) HRM2_14310(aor4) HRM2_33750(aor6) HRM2_38620(aor7) HRM2_38700(aor8) HRM2_44080
HOH: Hoch_5245
RRU: Rru_A0313
RRF: F11_01580
MAGX: XM1_2180(aor)
MAGN: WV31_18645
AZL: AZL_b04690(aor)
ALI: AZOLI_p20536(aor1) AZOLI_p40585(aor2)
BBEV: BBEV_1357(aor)
BSE: Bsel_2218
CAC: CA_C2018
CAE: SMB_G2050(aor)
CAY: CEA_G2033
CBO: CBO1935(aorA)
CBA: CLB_1874(aor)
CBH: CLC_1881(aor)
CBY: CLM_2153(aor)
CBL: CLK_1393(aor)
CBB: CLD_2688(aor)
CBI: CLJ_B2140(aor)
CBF: CLI_2002(aor)
CBM: CBF_1985(aor)
CLD: CLSPO_c19340(aor)
CACE: CACET_c07960(aor1) CACET_c29650(aor2) CACET_c29960(aor3) CACET_c37470(aor4) CACET_c38030(aor5)
CPRO: CPRO_17430(ydhV)
EAC: EAL2_808p04810(aor)
DHD: Dhaf_2056
HMO: HM1_0998(aor)
AWO: Awo_c12420(for)
THX: Thet_1521
CHY: CHY_0789(aor1) CHY_1329(aor2) CHY_1712(aor3) CHY_1747(aor4)
TPZ: Tph_c04180(aor1) Tph_c07080(aor2) Tph_c08220(aor3) Tph_c19480(aor4) Tph_c20350(aor5) Tph_c27630(aor6)
CSC: Csac_0969
ATE: Athe_0821
TOC: Toce_0383
CAD: Curi_c25040(aor)
PUF: UFO1_3797
KFL: Kfla_2116
ELE: Elen_2089
CAU: Caur_1533
HAU: Haur_3590
TRO: trd_A0661
STI: Sthe_3386
IPA: Isop_2935
CACI: CLOAM0709(aorA)
HTH: HTH_1132(aor)
TAL: Thal_0420
PMO: Pmob_0381
MARN: LN42_06245
KOL: Kole_1088
CEX: CSE_00260(aor) CSE_09310(aor)
MOX: DAMO_2797(aor)
MBAK: MSBR3_3214
MPY: Mpsy_1578
MTP: Mthe_0900
MHI: Mhar_2265
MHU: Mhun_1005
MLA: Mlab_0187
MPL: Mpal_1563
MEZ: Mtc_1223(aor-1) Mtc_2235(aor-2)
RCI: RCIX2090(aor-1) RRC230(aor-2)
HHB: Hhub_1893(aor1) Hhub_2743(aor2) Hhub_3621(aor3)
HHSR: HSR6_0779 HSR6_1817(aor) HSR6_2037(aor2)
HMA: rrnAC1318(aor2) rrnAC2064(aor1)
HHI: HAH_1907(aor1) HAH_2534(aor2) HAH_2557(aor3)
NPH: NP_1432A(aor2) NP_4964A(aor1) NP_5016A(aor4) NP_6186A(aor3)
NMO: Nmlp_1571(aor3) Nmlp_3660(aor2) Nmlp_3663(aor1)
HVO: HVO_2183(aor4) HVO_B0244(aor1) HVO_B0256(aor3)
HME: HFX_2008(aor_3) HFX_2242(aor1)
NAT: NJ7G_3998
TVO: TVG0808604(TVG0808604) TVG1304136(TVG1304136)
PHO: PH0028(PH0028) PH0892(PH0892) PH1019(PH1019) PH1274(PH1274)
PAB: PAB0647(aor-2) PAB0798(for) PAB2085 PAB2330
TGA: TGAM_0734(aor-1) TGAM_1913(aor-4)
APE: APE_0266.1(aor)
TTN: TTX_1294(aor-2) TTX_1396(for) TTX_1768(aor-3)
NAA: Nps_02780
BARC: AOA65_0066(for) AOA65_0445(aor_1) AOA65_0446(aor_2) AOA65_0526(aor_3) AOA65_1742(aor_6) AOA65_1862(aor_7) AOA65_1876(aor_8) AOA65_2232(aor_9)
BARB: AOA66_1498(aor_1) AOA66_1651(for) AOA66_1739(aor_2) AOA66_1771(aor_3) AOA66_1772(aor_4) AOA66_1773(aor_5) AOA66_1774(aor_6)
 » show all
Taxonomy
Reference
1  [PMID:1907273]
  Authors
Mukund S, Adams MW.
  Title
The novel tungsten-iron-sulfur protein of the hyperthermophilic archaebacterium, Pyrococcus furiosus, is an aldehyde ferredoxin oxidoreductase. Evidence for its participation in a unique glycolytic pathway.
  Journal
J. Biol. Chem. 266 (1991) 14208-16.
  Sequence
[pfu:PF0346]
Reference
2  [PMID:8444863]
  Authors
Johnson JL, Rajagopalan KV, Mukund S, Adams MW.
  Title
Identification of molybdopterin as the organic component of the tungsten cofactor in four enzymes from hyperthermophilic Archaea.
  Journal
J. Biol. Chem. 268 (1993) 4848-52.
Reference
3  [PMID:7878465]
  Authors
Chan MK, Mukund S, Kletzin A, Adams MW, Rees DC.
  Title
Structure of a hyperthermophilic tungstopterin enzyme, aldehyde ferredoxin oxidoreductase.
  Journal
Science. 267 (1995) 1463-9.
  Sequence
[pfu:PF0346]
Reference
4  [PMID:11265456]
  Authors
Roy R, Menon AL, Adams MW.
  Title
Aldehyde oxidoreductases from Pyrococcus furiosus.
  Journal
Methods. Enzymol. 331 (2001) 132-44.
Other DBs
ExplorEnz - The Enzyme Database: 1.2.7.5
IUBMB Enzyme Nomenclature: 1.2.7.5
ExPASy - ENZYME nomenclature database: 1.2.7.5
BRENDA, the Enzyme Database: 1.2.7.5
CAS: 138066-90-7

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