KEGG   ENZYME: 1.20.4.2Help
Entry
EC 1.20.4.2                 Enzyme                                 

Name
methylarsonate reductase;
MMA(V) reductase
Class
Oxidoreductases;
Acting on phosphorus or arsenic in donors;
With disulfide as acceptor
BRITE hierarchy
Sysname
gluthathione:methylarsonate oxidoreductase
Reaction(IUBMB)
methylarsonate + 2 glutathione = methylarsonite + glutathione disulfide + H2O [RN:R05748]
Reaction(KEGG)
Substrate
methylarsonate [CPD:C07294];
glutathione [CPD:C00051]
Product
methylarsonite [CPD:C07295];
glutathione disulfide [CPD:C00127];
H2O [CPD:C00001]
Comment
The product, Me-As(OH)2 (methylarsonous acid), is biologically methylated by EC 2.1.1.137, arsenite methyltransferase, to form cacodylic acid (dimethylarsinic acid).
History
EC 1.20.4.2 created 2000 as EC 1.97.1.7, transferred 2001 to EC 1.20.4.2, modified 2003
Reference
1  [PMID:10604879]
  Authors
Zakharyan RA, Aposhian HV.
  Title
Enzymatic reduction of arsenic compounds in mammalian systems: the rate-limiting enzyme of rabbit liver arsenic biotransformation is MMA(V) reductase.
  Journal
Chem. Res. Toxicol. 12 (1999) 1278-83.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
UM-BBD (Biocatalysis/Biodegradation Database): 
BRENDA, the Enzyme Database: 
CAS: 
254889-62-8

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