| Entry |
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| Name |
isopenicillin-N synthase;
isopenicillin N synthetase
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| Class |
Oxidoreductases;
Acting on X-H and Y-H to form an X-Y bond;
With oxygen as acceptor
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| Sysname |
N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine:oxygen oxidoreductase (cyclizing)
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| Reaction(IUBMB) |
N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2 = isopenicillin N + 2 H2O
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| Reaction(KEGG) |
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| Substrate |
N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine;
O2 [CPD: C00007]
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| Product |
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| Comment |
Forms part of the penicillin biosynthesis pathway (for pathway, click here).
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| Pathway |
| Penicillin and cephalosporin biosynthesis | | Metabolic pathways | | Biosynthesis of secondary metabolites |
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| Orthology |
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| Genes |
VVU: | | VVY: | | VVM: | | VPA: | | VPB: | | VHA: | | VSP: | | VEX: | | VEJ: | | VFU: | | VFI: | | VFM: | | VSA: | | PPR: | | ACI: | | SON: | | SDN: | | SFR: | | SAZ: | | SBL: | | SBM: | | SBN: | | SBP: | | SBT: | | SBS: | | SBB: | | SLO: | | SPC: | | SHP: | | SSE: | | SPL: | | SHE: | | SHM: | | SHN: | | SHW: | | SHL: | | SWD: | | SWP: | | SVO: | | CPS: | | PHA: | | PAT: | | PSM: | | AMAC: | | AMB: | | AMG: | | AMK: | | AMAA: | | ALT: | | GAG: | | GNI: | | GPS: | | FBL: | | FTR: | | FTT: | | FTG: | | FTS: | | FTI: | | FCF: | | FCN: | | FPH: | | FRT: | | FNA: | | MMW: | | MME: | | MPC: | | AHA: | | ASA: | | AVR: | | CVI: | | PSE: | | TMO: | | SYNE: | | SYNP: | | CYN: | | AMR: | | PSEU: | |
» show all
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| Reference |
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| Authors |
Huffman GW, Gesellchen PD, Turner JR, Rothenberger RB, Osborne HE, Miller FD, Chapman JL, Queener SW. |
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| Title |
Substrate specificity of isopenicillin N synthase. |
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| Journal |
J. Med. Chem. 35 (1992) 1897-914. |
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| Organism |
Cephalosporium acremonium, Penicillium chrysogenum |
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| Reference |
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| Authors |
Roach PL, Clifton IJ, Fulop V, Harlos K, Barton GJ, Hajdu J, Andersson I, Schofield CJ, Baldwin JE. |
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| Title |
Crystal structure of isopenicillin N synthase is the first from a new structural family of enzymes. |
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| Journal |
Nature. 375 (1995) 700-4. |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: CAS: 78642-31-6 |
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