| Entry |
|
|---|
| Name |
isopenicillin-N synthase;
isopenicillin N synthetase |
|---|
| Class |
Oxidoreductases;
Acting on X-H and Y-H to form an X-Y bond;
With oxygen as acceptor
 |
|---|
| Sysname |
N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine:oxygen
oxidoreductase (cyclizing) |
|---|
| Reaction(IUBMB) |
N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2 =
isopenicillin N + 2 H2O |
|---|
| Reaction(KEGG) |
(other) R04872
 |
|---|
| Substrate |
N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine;
O2 [CPD:C00007] |
|---|
| Product |
isopenicillin N [CPD:C05557];
H2O [CPD:C00001] |
|---|
| Comment |
Forms part of the penicillin biosynthesis pathway (for pathway,
click here). |
|---|
| Pathway |
PATH: ec00311 Penicillin and cephalosporin biosynthesis
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K04126 isopenicillin-N synthase |
|---|
| Genes |
VVU: VV2_0260
VVY: VVA0764
VPA: VPA0866
VFI: VF_1657
PPR: PBPRB0800
ACI: ACIAD2388
SON: SO_2589
SDN: Sden_2305
SAZ: Sama_1992
SPC: Sputcn32_1753
SSE: Ssed_2637
SHN: Shewana3_2394
CPS: CPS_1982
PHA: PSHAa1932
PAT: Patl_0531
AHA: AHA_3601
ASA: ASA_3563
CVI: CV_0045
MXA: MXAN_0088
AVA: Ava_5009
 |
|---|
| Structures |
PDB: 1ODM 1UZW 1W03 1W04 1W05 1W06 1W3V 1W3X 2BJS 2BU9
2IVI 2IVJ 2JB4 2VAU 2VBB 2VBD 2VBP 2VCM 2VE1 |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:1588566]
Huffman GW, Gesellchen PD, Turner JR, Rothenberger RB, Osborne HE,
Miller FD, Chapman JL, Queener SW.
Substrate specificity of isopenicillin N synthase.
J. Med. Chem. 35 (1992) 1897-914.
Cephalosporium acremonium, Penicillium chrysogenum |
|---|
Reference
Authors
Title
Journal
|
2 [PMID:7791906]
Roach PL, Clifton IJ, Fulop V, Harlos K, Barton GJ, Hajdu J,
Andersson I, Schofield CJ, Baldwin JE.
Crystal structure of isopenicillin N synthase is the first from a
new structural family of enzymes.
Nature. 375 (1995) 700-4. |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.21.3.1
IUBMB Enzyme Nomenclature: 1.21.3.1
ExPASy - ENZYME nomenclature database: 1.21.3.1
BRENDA, the Enzyme Database: 1.21.3.1
CAS: 78642-31-6 |
|---|
