| Entry |
|
|---|
| Name |
columbamine oxidase;
berberine synthase |
|---|
| Class |
Oxidoreductases;
Acting on X-H and Y-H to form an X-Y bond;
With oxygen as acceptor
 |
|---|
| Sysname |
columbamine:oxygen oxidoreductase (cyclizing) |
|---|
| Reaction(IUBMB) |
2 columbamine + O2 = 2 berberine + 2 H2O [RN:R00044] |
|---|
| Reaction(KEGG) |
R00044
 |
|---|
| Substrate |
columbamine [CPD:C01795];
O2 [CPD:C00007] |
|---|
| Product |
berberine [CPD:C00757];
H2O [CPD:C00001] |
|---|
| Cofactor |
Iron [CPD:C00023] |
|---|
| Comment |
An iron protein. Oxidation of the O-methoxyphenol structure forms
the methylenedioxy group of berberine. |
|---|
| Pathway |
PATH: ec00950 Isoquinoline alkaloid biosynthesis
PATH: ec01063 Biosynthesis of alkaloids derived from shikimate
pathway |
|---|
Reference
Authors
Title
Journal
|
1
Rueffer, M. and Zenk, M.H.
Berberine synthesis, the methylenedioxy group forming enzyme in
berberine synthesis.
Tetrahedron Lett. 26 (1985) 201-202. |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.21.3.2
IUBMB Enzyme Nomenclature: 1.21.3.2
ExPASy - ENZYME nomenclature database: 1.21.3.2
BRENDA, the Enzyme Database: 1.21.3.2
CAS: 95329-18-3 |
|---|
