KEGG   ENZYME: 1.22.1.1Help
Entry
EC 1.22.1.1                 Enzyme                                 
Name
iodotyrosine deiodinase;
iodotyrosine dehalogenase 1;
DEHAL1
Class
Oxidoreductases;
Acting on halogen in donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
NADP+:L-tyrosine oxidoreductase (iodinating)
Reaction(IUBMB)
L-tyrosine + 2 NADP+ + 2 I- = 3,5-diiodo-L-tyrosine + 2 NADPH + 2 H+ (overall reaction) [RN:R10059];
(1a) L-tyrosine + NADP+ + I- = 3-iodo-L-tyrosine + NADPH + H+ [RN:R09521];
(1b) 3-iodo-L-tyrosine + NADP+ + I- = 3,5-diiodo-L-tyrosine + NADPH + H+ [RN:R09522]
Reaction(KEGG)
Substrate
L-tyrosine [CPD:C00082];
NADP+ [CPD:C00006];
I- [CPD:C00708];
3-iodo-L-tyrosine [CPD:C02515]
Product
3,5-diiodo-L-tyrosine [CPD:C01060];
NADPH [CPD:C00005];
H+ [CPD:C00080];
3-iodo-L-tyrosine [CPD:C02515]
Comment
The enzyme activity has only been demonstrated in the direction of 3-deiodination. Present in a transmembrane flavoprotein. Requires FMN.
Reference
1  [PMID:4394169]
  Authors
Rosenberg IN
  Title
Purification of iodotyrosine deiodinase from bovine thyroid.
  Journal
Metabolism. 19 (1970) 785-98.
  Organism
Bos taurus [GN:bta]
Reference
2  [PMID:15289438]
  Authors
Gnidehou S, Caillou B, Talbot M, Ohayon R, Kaniewski J, Noel-Hudson MS, Morand S, Agnangji D, Sezan A, Courtin F, Virion A, Dupuy C
  Title
Iodotyrosine dehalogenase 1 (DEHAL1) is a transmembrane protein involved in the recycling of iodide close to the thyroglobulin iodination site.
  Journal
FASEB. J. 18 (2004) 1574-6.
  Organism
Homo sapiens [GN:hsa], Sus scrofa [GN:ssc]
Reference
3  [PMID:16316988]
  Authors
Friedman JE, Watson JA Jr, Lam DW, Rokita SE
  Title
Iodotyrosine deiodinase is the first mammalian member of the NADH oxidase/flavin  reductase superfamily.
  Journal
J. Biol. Chem. 281 (2006) 2812-9.
  Organism
Homo sapiens [GN:hsa], Mus musculus [GN:mmu]
Reference
4  [PMID:19436071]
  Authors
Thomas SR, McTamney PM, Adler JM, Laronde-Leblanc N, Rokita SE
  Title
Crystal structure of iodotyrosine deiodinase, a novel flavoprotein responsible for iodide salvage in thyroid glands.
  Journal
J. Biol. Chem. 284 (2009) 19659-67.
  Organism
Homo sapiens [GN:hsa]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
DBGET integrated database retrieval system